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Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement
Abstract
In physiological fluids and seawater, adhesion of synthetic polymers to solid surfaces is severely limited by high salt, pH, and hydration, yet these conditions have not deterred the evolution of effective adhesion by mussels. Mussel foot proteins provide insights about adhesive adaptations: Notably, the abundance and proximity of catecholic Dopa (3,4-dihydroxyphenylalanine) and lysine residues hint at a synergistic interplay in adhesion. Certain siderophores—bacterial iron chelators—consist of paired catechol and lysine functionalities, thereby providing a convenient experimental platform to explore molecular synergies in bioadhesion. These siderophores and synthetic analogs exhibit robust adhesion energies (E(ad) ≥-15 millijoules per square meter) to mica in saline pH 3.5 to 7.5 and resist oxidation. The adjacent catechol-lysine placement provides a "one-two punch," whereby lysine evicts hydrated cations from the mineral surface, allowing catechol binding to underlying oxides.
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“Recent studies show that the synergistic effect of cation and catechol promoted wet adhesion [102,103].”
From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [102]
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Metadata
- Authors
- Maier, G. P., Rapp, M. V., Waite, J. H., Israelachvili, J. N., & Butler, A.
- Affiliations
- University of California, Santa Barbara (US)
- Corresponding author
- Maier, Greg P.
- Rapp, Michael V.
- Waite, J. Herbert
- Israelachvili, Jacob N.
- Butler, Alison
- Venue
- Science
- Published
- 2015-08-07
- Volume
- 349
- Issue
- 6248
- Pages
- 628-632
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1585589485
- Cited by
- 722
- References
- 30
- Citations by year
- 2026: 44 · 2025: 63 · 2024: 64 · 2023: 80 · 2022: 96 · 2021: 98 · 2020: 66 · 2019: 58 · 2018: 61 · 2017: 55 · 2016: 33 · 2015: 4
- FWCI
- 19.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (DMR 1121053)
- NSF (CHE-1411942)
- NSF GRFP
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Engineering › Ocean Engineering › Marine Biology and Environmental Chemistry
- Physical Sciences › Engineering › Mechanics of Materials › Adhesion, Friction, and Surface Interactions
- Keywords
- wet adhesion, catechol, lysine, mussel foot proteins, DOPA, siderophores, bioadhesion, synthetic polymers, mica, saline environment, adhesion energy, iron chelators
- MeSH terms
- Adhesiveness, Adhesives, Aluminum Silicates, Catechols, Dihydroxyphenylalanine, Hydrogen-Ion Concentration, Lysine, Oxidation-Reduction, Proteins, Titanium, Siderophores, Molecular Mimicry
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