Activation of proto-oncogenes by disruption of chromosome neighborhoods
Hnisz, Denes, Weintraub, Abraham S., Day, Daniel S., Valton, Anne-Laure, Bak, Rasmus O., Li, Charles H., Goldmann, Johanna, Lajoie, Bryan R., Fan, Zi Peng, Sigova, Alla A., Reddy, Jessica, Borges-Rivera, Diego, Lee, Tong Ihn, Jaenisch, Rudolf, Porteus, Matthew H., Dekker, Job, Young, Richard A.·2016·Science
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- Crosstalk Between Cis-Regulatory Elements and Metabolism Reprogramming in Hepatocellular CarcinomaYuqing Ren, Di Tang, Xiaofan Ding, Mian He · 2026 · Cancers
- Genomic Insights into the Biology of T-lineage Acute Lymphoblastic LeukemiaPetri Pölönen, David T. Teachey, Charles Grenfell Mullighan · 2026 · Blood Cancer Discovery
- Cellular plasticity of cancer: roles of biomolecular condensates and ecDNAYohei Sugimoto, Yihao Zhang, Takeru Kachi, Koichi Ogami, Hiroshi I. Suzuki · 2026 · Japanese Journal of Clinical Oncology
- Emergent domain segregation in self-interacting polymers explains chromosome 3D conformations in single human cellsMattia Conte, Simona Bianco, Sougata Guha, Andrea M. Chiariello, Andrea Esposito, Alex Abraham, Sumanta Kundu, Francesca Vercellone, Andrea Fontana, Florinda Di Pierno et al. · 2026 · Physical review. E
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- Promoter reinforcement supports transcriptional resilience in drug-resistant cancerVasumathi Kameswaran, Sayantanee Paul, Daniel Le, Alissa D. Guarnaccia, Jonathan Hoover, Liangfu Chen, Thijs J. Hagenbeek, Minyi Shi, Lu Zhao, Jessica M. Lund et al. · 2026 · Nature Structural & Molecular Biology
- 4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer developmentXiaoli Xie, Delin Tan, Jingyun Mo, Yang Xu, Qingqiang Ni, Ting Liu, Huaiming Wang, Bingjie Chen, Yujia Liao, Yingnan Lin et al. · 2026 · Nature Cell Biology
- From Chromosome Conformation Capture to Polymer Physics and BackGuido Tiana, Édith Heard, Luca Giorgetti · 2017 · Elsevier eBooks
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- Epigenome editing in cancer: Advances and challenges for potential therapeutic optionsSeung-Won Lee, Connor Mitchell Frankston, Jungsun Kim · 2023 · International review of cytology
- DeepCBS: shedding light on the impact of mutations occurring at CTCF binding sitesYiheng Wang, Xingli Guo, Zhixin Niu, Xiaotai Huang, Bingbo Wang, Lin Gao · 2024 · Frontiers in Genetics
- Gene Therapy and Gene EditingNiloofar Bazazzadegan, Mandana Hasanzad, Seyedeh Sedigheh Abedini · 2024 · Springer eBooks
- Chromatin interaction-based annotation of regulatory elements reveals dynamic promoter-enhancer interactions in lymphocyte developmentJohanna Tingvall-Gustafsson, Christina T. Jensen, Jonas Ungerbäck, Mikael Sigvardsson · 2025 · iScience
- Deregulation of the non-coding genome in leukemiaSusanna Teppo, Merja Heinäniemi, Olli Lohi · 2017 · RNA Biology
- Dysregulation of Cis-Regulatory Elements in CancerJayne A. Barbour, Jason W.H. Wong · 2019 · Springer eBooks
- Deep Learning of CTCF-Mediated Chromatin Loops in 3D Genome OrganizationShuzhen Kuang, Liangjiang Wang · 2020 · Lecture notes in computer science
- Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?Andrew R. McEwan, Alasdair MacKenzie · 2020 · International Journal of Molecular Sciences
- Chromosome instability induced by mutations in TAD anchors leads to tumorsAndrey N. Luchnik · 2021 · Genome Instability & Disease
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- Higher-order Chromatin Organization in Diseases, from Chromosomal Position Effect to Phenotype VariegationFrédérique Magdinier, Jérôme D. Robin · 2022 · Elsevier eBooks
- Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1–aging and epigenomicsAlbert Stuart Reece, Gary Kenneth Hulse · 2023 · Frontiers in Psychiatry
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- 3D Genome Analysis Identifies Enhancer Hijacking Mechanism for High-Risk Factors in Human T-Lineage Acute Lymphoblastic LeukemiaLu Yang, Fengling Chen, Haichuan Zhu, Yang Chen, Bingjie Dong, Minglei Shi, Weitao Wang, Qian Jiang, Le‐Ping Zhang, Xiao‐Jun Huang et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Disruption of the topological associated domain at Xp21.2 is related to gonadal dysgenesis: A general mechanism of pathogenesisAna Paula Santos, Jakob A. Meinel, Cristiane S.C. Piveta, Juliana Gabriel Ribeiro de Andrade, Helena Fabbri‐Scallet, Vera Lúcia Gil‐da‐Silva‐Lopes, Gil Guerra‐Júnior, Axel Künstner, Frank J. Kaiser, Paul‐Martin Holterhus et al. · 2020 · medRxiv
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- Myeloid leukemia vulnerabilities at CTCF-enriched long noncoding RNA lociMichelle Shu Wen Ng, Lonneke Verboon, Hasan Issa, Raj Bhayadia, Oriol Alejo-Valle, Dorit Borchert, K Schuschel, Enikő Regényi, Dirk Reinhardt, Marie‐Laure Yaspo et al. · 2021 · Research Square
- Examining dynamics of three-dimensional genome organization with multi-task matrix factorizationDa-Inn Lee, Sushmita Roy · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- KSHV Terminal Repeat Regulates Inducible Lytic Gene PromotersYoshihiro Izumiya, Adhraa Algalil, Jonna Magdallene Espera, Hiroki Miura, Tomoki Inagaki, Chie Izumiya, Ashish Kumar · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
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- Pushing boundariesGemma K. Alderton · 2016 · Nature reviews. Cancer
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- Novel Insights From Comprehensive Genomic Profiling of T Cell Acute Lymphoblastic LeukemiaDavid T. Teachey · 2018 · The Hematologist
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