The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
Open accessAbstract
Mitosis-specific role of ATR: The ATR (ataxia telangiectasia mutated and Rad3-related) kinase plays important roles in the S phase and during the DNA damage response to safeguard genome integrity. Kabeche et al. identified a distinct ATR activation pathway in mitosis that is also critical for suppressing genome instability (see the Perspective by Saldivar and Cimprich). ATR is recruited by Aurora A and activated by R loops at centromeres of mitotic chromosomes; this leads to Aurora B activation, which is necessary for accurate chromosome segregation. This mitotic, R loop–driven ATR signaling pathway could potentially be exploited in the search for cancer therapeutics. Science , this issue p. 108 ; see also p. 30
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Cites
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
Self-citationCauses and consequences of replication stress
Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Sensing centromere tension: Aurora B and the regulation of kinetochore function
Lampson, M. A., & Cheeseman, I. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.10.007 · Cited by 375
Buisson, R., Boisvert, J. L., Benes, C. H., & Zou, L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.029 · Cited by 316
Self-citationThe origins and processing of ultra fine anaphase DNA bridges
Liu, Y., Nielsen, C. F., Yao, Q., & Hickson, I. D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.003 · Cited by 145
Cited by
R-Loops as Cellular Regulators and Genomic Threats
Crossley, M. P., Bocek, M., & Cimprich, K. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.024 · Cited by 746
Targeting replication stress in cancer therapy
da Costa, A. A. B. A., Chowdhury, D., Shapiro, G. I., D’Andrea, A. D., & Konstantinopoulos, P. A. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00558-5 · Cited by 359
Warrier, V., Stauffer, E.-M., Huang, Q. Q., Wigdor, E. M., Slob, E. A. W., Seidlitz, J., Ronan, L., Valk, S. L., Mallard, T. T., Grotzinger, A. D., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01475-y · Cited by 91
Metadata
- Authors
- Kabeche, L., Nguyen, H. D., Buisson, R., & Zou, L.
- Venue
- Science
- Published
- 2018-01-05
- Volume
- 359
- Issue
- 6371
- Pages
- 108-114
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2770128744
- Cited by
- 303
- References
- 7
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- green
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