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High-fructose corn syrup enhances intestinal tumor growth in mice
Open accessAbstract
A sweetener's not-so-sweet effects: Obesity increases an individual's risk of developing many types of cancer, including colorectal cancer. One of the factors driving the rise in obesity rates is thought to be the use of high-fructose corn syrup (HFCS) as a sweetener in soft drinks. Goncalves et al. found that ingestion of HFCS promotes the growth of intestinal cancer even in the absence of obesity in mouse tumor models. An enzyme in tumors (ketohexokinase) converts fructose to fructose-1-phosphate, which alters tumor cell metabolism and leads to enhanced cell growth. Whether a similar process occurs in humans remains to be seen. Science , this issue p. 1345
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“A recent animal study showed that high fructose corn syrup intake could induce intestinal tumourigenesis in mice by expediting glycolysis and de novo lipogenesis. The mice treated with the syrup had a substantially increased tumour size and tumour grade, independent of obesity and metabolic syndrome.124”
From Dietary sugar consumption and health: umbrella review (2023) · cites this paper as [124]
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Xie, J., Shi, S., Liu, Y., Wang, S., Rajput, S. A., & Song, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.922051 · Cited by 4
Fasting and cancer responses to therapy
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Fructose Metabolism and Acute Myeloid Leukemia
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Fructose, Another Sweet for Cancer: A Context Acting Nutrient Hypothesis
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Liver-like glycogen metabolism supports glycolysis in naked mole-rat heart during ischaemiaPreprint
Bundgaard, A., Wang, N., Vyshkvorkina, I., Burbano, M. S. J., Cherevatenko, M., Georgomanolis, T., Dethloff, F., Giavalisco, P., Lackmann, J., Lewin, G. R., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.09.598072 · Cited by 4
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“In Apc-/- models colorectal cancer models, long-term moderate fructose intake increased tumor incidence through activation of glycolysis and fatty acid synthesis pathways (111).”
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Role of Diet in the Pathogenesis of Colorectal Polyps and Cancer
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InfluentialThe Influence of Diet on Cancer Progression and Treatment
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“Sickeningly Sweet”…. High-Fructose Corn Syrup-Caveat Emptor!
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Metadata
- Authors
- Goncalves, M. D., Lu, C., Tutnauer, J., Hartman, T. E., Hwang, S.-K., Murphy, C. J., Pauli, C., Morris, R., Taylor, S., Bosch, K., Yang, S., Wang, Y., Van Riper, J., Lekaye, H. C., Roper, J., Kim, Y., Chen, Q., Gross, S. S., Rhee, K. Y., Cantley, L. C., & Yun, J.
- Affiliations
- Weill Cornell Medicine (US)
- University Hospital Zurich (CH)
- Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
- Tisch Cancer Institute (US)
- Baylor College of Medicine (US)
- Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- Duke University (US)
- Chonnam National University (KR)
- Corresponding author
- Cantley, Lewis C.
- Yun, Jihye
- ORCID
- Venue
- Science
- Published
- 2019-03-22
- Volume
- 363
- Issue
- 6433
- Pages
- 1345-1349
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC6487857
- OpenAlex
- W2922809418
- Cited by
- 374
- References
- 52
- Citations by year
- 2026: 32 · 2025: 36 · 2024: 44 · 2023: 66 · 2022: 56 · 2021: 70 · 2020: 55 · 2019: 15
- FWCI
- 39.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institutes of Health (R01 NS093872, R35 CA197588, KL2 Scholar 2014 [Y8-H], CA230318)
- National Cancer Institute (1K22CA216036)
- National Institute of Child Health and Human Development (PO1 HD067244)
- Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (SU2C-AACR-DT22-17)
- Cancer Prevention and Research Institute of Texas (RR170039)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- high fructose corn syrup, colorectal cancer, fructose, dietary glucose, fructose-1-phosphate, glycolysis, fatty acid synthesis, carcinogenesis, sugar-sweetened beverages, obesity
- MeSH terms
- Animals, Diet, Intestinal Neoplasms, Mice, Mutant Strains, Adenomatous Polyposis Coli Protein, Tumor Burden, Mice, Neoplasm Grading, Carcinogenesis, High Fructose Corn Syrup
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