Cited by 374Diet, Metabolism, and DiseaseMetabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

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High-fructose corn syrup enhances intestinal tumor growth in mice

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Goncalves, Marcus D., Lu, Changyuan, Tutnauer, Jordan, Hartman, Travis E., Hwang, Seo-Kyoung, Murphy, Charles J, Pauli, Chantal, Morris, Roxanne, Taylor, Sam, Bosch, Kaitlyn, Yang, Sukjin, Wang, Yumei, Van Riper, Justin, Lekaye, H Carl, Roper, Jatin, Kim, Young, Chen, Qiuying, Gross, Steven S., Rhee, Kyu Y., Cantley, Lewis C., Yun, Jihye·2019·Science

DOI 10.1126/science.aat8515PMC PMC6487857

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Abstract

A sweetener's not-so-sweet effects: Obesity increases an individual's risk of developing many types of cancer, including colorectal cancer. One of the factors driving the rise in obesity rates is thought to be the use of high-fructose corn syrup (HFCS) as a sweetener in soft drinks. Goncalves et al. found that ingestion of HFCS promotes the growth of intestinal cancer even in the absence of obesity in mouse tumor models. An enzyme in tumors (ketohexokinase) converts fructose to fructose-1-phosphate, which alters tumor cell metabolism and leads to enhanced cell growth. Whether a similar process occurs in humans remains to be seen. Science , this issue p. 1345

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Additional file 7 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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Additional file 1 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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Additional file 4 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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Additional file 5 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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Additional file 2 of Association between cigarette smoking and colorectal cancer sidedness: A multi-center big-data platform-based analysis
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Additional file 2 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
Cui, Y., Liu, H., Wang, Z., Zhang, H., Tian, J., Wang, Z., Song, W., Guo, H., Liu, L., Tian, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23803243
Additional file 8 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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Additional file 6 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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Additional file 3 of Fructose promotes angiogenesis by improving vascular endothelial cell function and upregulating VEGF expression in cancer cells
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“Furthermore, two previous studies reported a combination of a DNL inhibitor and low-fat diets [80, 81] for patients with intestinal cancer.”
Three dual-site naphthalimide fluorescent probes for the regulation of fluorescence properties of methylglyoxal and formaldehyde and their applications
Wu, X., Li, Z., & 杨绍祥 (2026) · Analytical Methods · doi:10.1039/d6ay01788f
Ketohexokinase inhibitor discovery and clinical translation: Medicinal chemistry, tissue pharmacology, and biomarker-guided development
Li, W., Zhu, K., Wu, L., Liao, Y., Liang, Y., Liu, M., & Chen, H. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119434
Advanced Nanomedicines for Cancer Metabolic Therapy
Duan, Q., Tian, C., Cheng, X., Wang, L., Huo, M., & Shi, J. (2026) · Advanced Materials · doi:10.1002/adma.75365

Authors: Goncalves, M. D., Lu, C., Tutnauer, J., Hartman, T. E., Hwang, S.-K., Murphy, C. J., Pauli, C., Morris, R., Taylor, S., Bosch, K., Yang, S., Wang, Y., Van Riper, J., Lekaye, H. C., Roper, J., Kim, Y., Chen, Q., Gross, S. S., Rhee, K. Y., Cantley, L. C., & Yun, J.
Affiliations: Weill Cornell Medicine (US)
University Hospital Zurich (CH)
Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Tisch Cancer Institute (US)
Baylor College of Medicine (US)
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Duke University (US)
Chonnam National University (KR)
Corresponding author: Cantley, Lewis C.
Yun, Jihye
ORCID: Goncalves, Marcus D.
Lu, Changyuan
Hartman, Travis E.
Hwang, Seo-Kyoung
Murphy, Charles J
Pauli, Chantal
Morris, Roxanne
Bosch, Kaitlyn
Yang, Sukjin
Wang, Yumei
Van Riper, Justin
Lekaye, H Carl
Roper, Jatin
Kim, Young
Chen, Qiuying
Gross, Steven S.
Rhee, Kyu Y.
Cantley, Lewis C.
Yun, Jihye
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-03-22
Volume: 363
Issue: 6433
Pages: 1345-1349
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aat8515
PMC: PMC6487857
OpenAlex: W2922809418
Cited by: 374
References: 52
Citations by year: 2026: 32 · 2025: 36 · 2024: 44 · 2023: 66 · 2022: 56 · 2021: 70 · 2020: 55 · 2019: 15
FWCI: 39.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Institutes of Health (R01 NS093872, R35 CA197588, KL2 Scholar 2014 [Y8-H], CA230318)
National Cancer Institute (1K22CA216036)
National Institute of Child Health and Human Development (PO1 HD067244)
Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant (SU2C-AACR-DT22-17)
Cancer Prevention and Research Institute of Texas (RR170039)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: high fructose corn syrup, colorectal cancer, fructose, dietary glucose, fructose-1-phosphate, glycolysis, fatty acid synthesis, carcinogenesis, sugar-sweetened beverages, obesity
MeSH terms: Animals, Diet, Intestinal Neoplasms, Mice, Mutant Strains, Adenomatous Polyposis Coli Protein, Tumor Burden, Mice, Neoplasm Grading, Carcinogenesis, High Fructose Corn Syrup

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High-fructose corn syrup enhances intestinal tumor growth in mice

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