The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Mitochondria-Striking a balance between host and endosymbiont
Abstract
Putting a price on the powerhouse: Mitochondria—the so-called powerhouse of the cell—are derived from bacterial endosymbionts. This history provides opportunities and challenges for their host cells, particularly metazoans, including humans. Youle reviews the interplay between host and mitochondrial biology and highlights how mitochondrial ancestry has influenced innate immune responses. Keeping mitochondria both healthy and in check is key to organismal health and, when perturbed, leads to a variety of pathologies, including Parkinson's disease and inflammation. Science , this issue p. eaaw9855
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“Protonophores induce mitophagy 170 , which might explain their positive effects on metabolism as well.”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [170]
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1 retracted
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
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Self-citationRetractedPINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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“Pathways downstream of innate immune signaling further link inflammation to adaptive immune responses in vertebrates (52).”
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Metadata
- Authors
- Youle, R. J.
- Affiliations
- Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA.
- Venue
- Science
- Published
- 2019-08-16
- Volume
- 365
- Issue
- 6454
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 199
- References
- 22
- Language
- en
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