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Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission
Abstract
Maternal inheritance of mitochondrial DNA results from autophagy-dependent clearance of paternal mitochondria.
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This autophagy targeting requires both the ubiquitination of substrates and the loss of sperm mitochondrial membrane potential.
“This autophagy targeting requires both the ubiquitination of substrates and the loss of sperm mitochondrial membrane potential [1108,1110,1111].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [1111]
Citations
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Metadata
- Authors
- Al Rawi, S., Louvet-Vallée, S., Djeddi, A., Sachse, M., Culetto, E., Hajjar, C., Boyd, L., Legouis, R., & Galy, V.
- Affiliations
- Université Pierre et Marie Curie-Paris VI, UMR7622–Biologie du Développement, 9 Quai St. Bernard, 75005 Paris, France.
- Plateforme de Microscopie Ultrastructurale, Imagopole, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France.
- Centre de Génétique Moléculaire–UPR3404–CNRS–Université Paris XI, Avenue de la Terrasse, 91198 Gif Sur Yvette, France.
- Department of Biological Sciences, University of Alabama, Huntsville, Huntsville, AL 35899, USA.
- Venue
- Science
- Published
- 2011-11-25
- Volume
- 334
- Issue
- 6059
- Pages
- 1144-1147
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 461
- References
- 2
- Language
- en
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