Cited by 336Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionCell Image Analysis Techniques

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Dense connectomic reconstruction in layer 4 of the somatosensory cortex

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Motta, Alessandro, Berning, Manuel, Boergens, Kevin M., Staffler, Benedikt, Beining, Marcel, Loomba, Sahil, Hennig, Philipp, Wissler, Heiko, Helmstaedter, Moritz·2019·Science

DOI 10.1126/science.aay3134

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Abstract

Brain anatomy revealed in startling detail: The mammalian cerebral cortex is an enormously complex network of neuronal processes that are long and thin, branching, and extremely densely packed. This high packing density has made the reconstruction of cortical neuronal networks challenging. Motta et al. used advanced automated imaging and analysis tools to reconstruct with high spatial resolution the morphological features of 89 neurons and their connections in the mouse barrel cortex. The reconstruction covered an area more than two orders of magnitude larger than earlier neuroanatomical mapping attempts. This approach revealed information about the connectivity of inhibitory and excitatory synapses of corticocortical as well as excitatory thalamocortical connections. Science , this issue p. eaay3134

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Authors: Motta, A., Berning, M., Boergens, K. M., Staffler, B., Beining, M., Loomba, S., Hennig, P., Wissler, H., & Helmstaedter, M.
Affiliations: Max Planck Institute for Brain Research (DE)
Max Planck Society (DE)
Corresponding author: Motta, Alessandro
Berning, Manuel
Boergens, Kevin M.
Staffler, Benedikt
Wissler, Heiko
ORCID: Motta, Alessandro
Berning, Manuel
Boergens, Kevin M.
Staffler, Benedikt
Beining, Marcel
Loomba, Sahil
Hennig, Philipp
Helmstaedter, Moritz
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-11-29
Volume: 366
Issue: 6469
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aay3134
OpenAlex: W2982268628
Cited by: 333
References: 101
Citations by year: 2026: 23 · 2025: 37 · 2024: 62 · 2023: 55 · 2022: 60 · 2021: 52 · 2020: 40 · 2019: 2
FWCI: 18.45
Type: journal article
Language: en
Open access: green
doi.org
Licence: cc-by-nc-nd
Locations: Science (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: Max-Planck-Gesellschaft
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Keywords: connectome reconstruction, barrel cortex, layer 4, somatosensory cortex, mice, Hebbian synaptic plasticity, long-term potentiation, neural circuits, 3D electron microscopy
MeSH terms: Animals, Axons, Male, Mice, Inbred C57BL, Microscopy, Electron, Neurons, Somatosensory Cortex, Synapses, Neuropil, Imaging, Three-Dimensional, Mice, Connectome

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Dense connectomic reconstruction in layer 4 of the somatosensory cortex

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