A common neuroendocrine substrate for diverse general anesthetics and sleep

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411 · see citing works

Millisecond-timescale, genetically targeted optical control of neural activity

Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works

Theta oscillations in the hippocampus

Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332 · see citing works

A mesoscale connectome of the mouse brain

Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612 · see citing works

Optogenetics in neural systems

Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881 · see citing works

DREADDs for neuroscientists

Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742 · see citing works

Neural correlates of consciousness: progress and problems

Koch, C., Massimini, M., Boly, M., & Tononi, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.22 · Cited by 1,600 · see citing works

General Anesthesia, Sleep, and Coma

Brown, E. N., Lydic, R., & Schiff, N. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0808281 · Cited by 1,346 · see citing works

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

Franks, N. P. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2372 · Cited by 1,266 · see citing works

Consciousness and Anesthesia

Alkire, M. T., Hudetz, A. G., & Tononi, G. (2008) · Science · doi:10.1126/science.1149213 · Cited by 1,245 · see citing works

High-performance genetically targetable optical neural silencing by light-driven proton pumps

Chow, B. Y., Han, X., Dobry, A. S., Qian, X., Chuong, A. S., Li, M., Henninger, M. A., Belfort, G. M., Lin, Y., Monahan, P. E., et al. (2010) · Nature · doi:10.1038/nature08652 · Cited by 1,188 · see citing works

Stimulus-transcription coupling in neurons: role of cellular immediate-early genes

Morgan, J. I., & Curran, T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90096-9 · Cited by 969 · cited 1× · see citing works

Neural Circuitry of Wakefulness and Sleep

Scammell, T. E., Arrigoni, E., & Lipton, J. O. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.014 · Cited by 966 · see citing works

Dendritic peptide release and peptide-dependent behaviours

Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

Mure, L. S., Le, H. D., Benegiamo, G., Chang, M. W., Ríos, L., Jillani, N., Ngotho, M., Kariuki, T., Dkhissi‐Benyahya, O., Cooper, H. M., et al. (2018) · Science · doi:10.1126/science.aao0318 · Cited by 783 · see citing works

Molecular and neuronal substrates for general anaesthetics

Rudolph, U., & Antkowiak, B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1496 · Cited by 771 · see citing works

Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

Sherin, J. E., Elmquist, J. K., Torrealba, F., & Saper, C. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04705.1998 · Cited by 746 · see citing works

Neurons for hunger and thirst transmit a negative-valence teaching signal

Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M. (2015) · Nature · doi:10.1038/nature14416 · Cited by 704 · see citing works

Activity-dependent regulation of inhibitory synapse development by Npas4

Lin, Y., Bloodgood, B. L., Hauser, J. L., Lapan, A. D., Koon, A. C., Kim, T.-K., Hu, L. S., Malik, A. N., & Greenberg, M. E. (2008) · Nature · doi:10.1038/nature07319 · Cited by 639 · see citing works

VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors

Eban-Rothschild, A., Rothschild, G., Giardino, W. J., Jones, J. R., & de Lecea, L. (2016) · Nature Neuroscience · doi:10.1038/nn.4377 · Cited by 583 · see citing works

Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice

Saito, M., Iwawaki, T., Taya, C., Yonekawa, H., Noda, M., Inui, Y., Mekada, E., Kimata, Y., Tsuru, A., & Kohno, K. (2001) · Nature Biotechnology · doi:10.1038/90795 · Cited by 512 · see citing works

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

Jego, S., Glasgow, S. D., Herrera, C. G., Ekstrand, M. I., Reed, S. J., Boyce, R., Friedman, J. M., Burdakov, D., & Adamantidis, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3522 · Cited by 454 · see citing works

Dynorphin and Vasopressin: Common Localization in Magnocellular Neurons

Watson, S. J., Akil, H., Fischli, W., D, A. G. M., Zimmerman, E. A., Nilaver, G., & Griedanus, T. B. V. W. (1982) · Science · doi:10.1126/science.6121376 · Cited by 415 · see citing works

Circuit-based interrogation of sleep control

Weber, F., & Dan, Y. (2016) · Nature · doi:10.1038/nature19773 · Cited by 378 · see citing works

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

Chung, S., Weber, F., Zhong, P., Tan, C. L., Nguyen, T. N., Beier, K. T., Hörmann, N., Chang, W.-C., Zhang, Z., Do, J. P., et al. (2017) · Nature · doi:10.1038/nature22350 · Cited by 317 · see citing works

Sleep Neurophysiological Dynamics Through the Lens of Multitaper Spectral Analysis

Prerau, M. J., Brown, R. E., Bianchi, M. T., Ellenbogen, J. M., & Purdon, P. L. (2016) · Physiology · doi:10.1152/physiol.00062.2015 · Cited by 308 · see citing works

Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

Van Dort, C. J., Zachs, D. P., Kenny, J. D., Zheng, S., Goldblum, R. R., Gelwan, N. A., Ramos, D. M., Nolan, M. A., Wang, K., Weng, F.-J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423136112 · Cited by 296 · see citing works

Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice

Kroeger, D., Absi, G., Gagliardi, C., Bandaru, S. S., Madara, J. C., Ferrari, L. L., Arrigoni, E., Münzberg, H., Scammell, T. E., Saper, C. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06590-7 · Cited by 276 · see citing works

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Zhang, Z., Ferretti, V., Güntan, İ., Moro, A., Steinberg, E. A., Ye, Z., Zecharia, A. Y., Yu, X., Vyssotski, A. L., Brickley, S. G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3957 · Cited by 275 · see citing works

Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia

Taylor, N. E., Van Dort, C. J., Kenny, J. D., Pei, J., Guidera, J. A., Vlasov, K. Y., Lee, J. T., Boyden, E. S., Brown, E. N., & Solt, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614340113 · Cited by 269 · see citing works

Neural circuits underlying thirst and fluid homeostasis

Zimmerman, C. A., Leib, D. E., & Knight, Z. A. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.71 · Cited by 262 · see citing works

Role of endogenous sleep-wake and analgesic systems in anesthesia

Lu, J., Nelson, L. E., Franks, N., Maze, M., Chamberlin, N. L., & Saper, C. B. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21685 · Cited by 230 · see citing works

Essential Thalamic Contribution to Slow Waves of Natural Sleep

David, F., Schmiedt, J. T., Taylor, H. L., Orbán, G., Giovanni, G. D., Uebele, V. N., Renger, J. J., Lambert, R. C., Leresche, N., & Crunelli, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3169-13.2013 · Cited by 223 · see citing works

Historical Development of Modern Anesthesia

Robinson, D. H., & Toledo, A. H. (2012) · Journal of Investigative Surgery · doi:10.3109/08941939.2012.690328 · Cited by 220 · see citing works

Regulation of REM and Non-REM Sleep by Periaqueductal GABAergic Neurons

Weber, F., Do, J. P. H., Chung, S., Beier, K. T., Bikov, M., Doost, M. S., & Dan, Y. (2018) · Nature Communications · doi:10.1038/s41467-017-02765-w · Cited by 214 · see citing works

Recurrent Circuitry for Balancing Sleep Need and Sleep

Donlea, J. M., Pimentel, D. O., Talbot, C. B., Kempf, A., Omoto, J. J., Hartenstein, V., & Miesenböck, G. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.016 · Cited by 212 · see citing works

Supramammillary glutamate neurons are a key node of the arousal system

Pedersen, N. P., Ferrari, L., Venner, A., Wang, J. L., Abbott, S. B. G., Vujovic, N., Arrigoni, E., Saper, C. B., & Fuller, P. M. (2017) · Nature Communications · doi:10.1038/s41467-017-01004-6 · Cited by 203 · see citing works

Prostaglandin D2 and sleep/wake regulation

Urade, Y., & Hayaishi, O. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.08.003 · Cited by 200 · see citing works

Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep

Akeju, O., & Brown, E. N. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.04.011 · Cited by 192 · see citing works

Adenosine and Sleep

Bjorness, T. E., & Greene, R. W. (2009) · Current Neuropharmacology · doi:10.2174/157015909789152182 · Cited by 178 · see citing works

Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit

Sakurai, K., Zhao, S., Takatoh, J., Rodriguez, E., Lu, J., Leavitt, A. D., Fu, M., Han, B.-X., & Wang, F. (2016) · Neuron · doi:10.1016/j.neuron.2016.10.015 · Cited by 177 · see citing works

Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis

Moore, J. T., Chen, J., Han, B., Meng, Q. C., Veasey, S. C., Beck, S. G., & Kelz, M. B. (2012) · Current Biology · doi:10.1016/j.cub.2012.08.042 · Cited by 171 · see citing works

Wakefulness Is Governed by GABA and Histamine Cotransmission

Yu, X., Ye, Z., Houston, C. M., Zecharia, A. Y., Ma, Y., Zhang, Z., Uygun, D. S., Parker, S., Vyssotski, A. L., Yustos, R., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.003 · Cited by 171 · see citing works

Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D 2

Scammell, T. E., Gerashchenko, D., Urade, Y., Onoe, H., Saper, C. B., & Hayaishi, O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7754 · Cited by 161 · see citing works

A Novel Role of Vasopressin in the Brain: Modulation of Activity-Dependent Water Flux in the Neocortex

Niermann, H., Amiry-Moghaddam, M. R., Holthoff, K., Witte, O. W., & Ottersen, O. P. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03045.2001 · Cited by 151 · see citing works

Recovery from Sleep Deprivation Occurs during Propofol Anesthesia

Tung, A., Bergmann, B. M., Herrera, S., Cao, D., & Mendelson, W. B. (2004) · Anesthesiology · doi:10.1097/00000542-200406000-00014 · Cited by 151 · see citing works

Identifying local and descending inputs for primary sensory neurons

Zhang, Y., Zhao, S., Rodriguez, E., Takatoh, J., Han, B.-X., Zhou, X., & Wang, F. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81156 · Cited by 138 · see citing works

Sleep Deprivation Potentiates the Onset and Duration of Loss of Righting Reflex Induced by Propofol and Isoflurane

Tung, A., Szafran, M. J., Bluhm, B., & Mendelson, W. B. (2002) · Anesthesiology · doi:10.1097/00000542-200210000-00024 · Cited by 112 · see citing works

Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep

Trudel, E., & Bourque, C. W. (2010) · Nature Neuroscience · doi:10.1038/nn.2503 · Cited by 111 · see citing works

GABA Is Excitatory in Adult Vasopressinergic Neuroendocrine Cells

Haam, J., Popescu, I., Morton, L. A., Halmos, K. C., Teruyama, R., Ueta, Y., & Tasker, J. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3826-11.2012 · Cited by 100 · see citing works

Excitatory pathways from the lateral habenula enable propofol-induced sedation

Gelegen, C., Miracca, G., Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., et al. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.050 · Cited by 100 · see citing works

Genetic and neuronal regulation of sleep by neuropeptide VF

Lee, D. A., Andreev, A., Truong, T. V., Chen, A., Hill, A. J., Oikonomou, G., Pham, U., Hong, Y. K., Tran, S., Glass, L., et al. (2017) · eLife · doi:10.7554/elife.25727 · Cited by 89 · see citing works

Lateral hypothalamic circuits for sleep–wake control

Yamashita, T., & Yamanaka, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.020 · Cited by 77 · see citing works

Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus

Greco, M.-A., Fuller, P. M., Jhou, T. C., Martin‐Schild, S., Zadina, J. E., Hu, Z., Shiromani, P. J., & Lu, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.043 · Cited by 76 · see citing works

Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non‐peptide oxytocin receptor agonist <scp>WAY</scp> 267,464: a biotelemetry study in rats

Hicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12613 · Cited by 76 · see citing works

Expression of the circadian clock gene Period 1 in neuroendocrine cells: an investigation using mice with a Per1::GFP transgene

Kriegsfeld, L. J., Korets, R., & Silver, R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02431.x · Cited by 75 · see citing works

Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats

Palin, K., Moreau, M. L., Sauvant, J., Orcel, H., Nadjar, A., Duvoid, A., Dudit, J., Rabié, A., & Moos, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90489.2008 · Cited by 73 · see citing works

Increases in amino-cupric-silver staining of the supraoptic nucleus after sleep deprivation

Eiland, M. M., Ramanathan, L., Gulyani, S., Gilliland, M. A., Bergmann, B. M., Rechtschaffen, A., & Siegel, J. M. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02448-4 · Cited by 67 · see citing works

Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish

Chen, S., Reichert, S., Singh, C., Oikonomou, G., Rihel, J., & Prober, D. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.001 · Cited by 58 · see citing works

Chronic in vivo multi-circuit neurophysiological recordings in mice

Dzirasa, K., Fuentes, R., Kumar, S., Potes, J. M., & Nicolelis, M. A. L. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.11.014 · Cited by 57 · see citing works

Distribution and chemical composition of estrogen receptor β neurons in the paraventricular nucleus of the female and male mouse hypothalamus

Oyola, M. G., Thompson, M. K., Handa, A. Z., & Handa, R. J. (2017) · Journal of Comparative Neurology · doi:10.1002/cne.24295 · Cited by 53 · see citing works

Optogenetics in mice performing a visual discrimination task: measurement and suppression of retinal activation and the resulting behavioral artifact

Danskin, B., Denman, D., Valley, M., Ollerenshaw, D., Williams, D., Groblewski, P., Reid, C., Olsen, S., & Waters, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144760 · Cited by 46 · see citing works

Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement

Bellavance, M.-A., Takatoh, J., Lu, J., Demers, M., Kleinfeld, D., Wang, F., & Deschênes, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.045 · Cited by 43 · see citing works

Vesicular Glutamate Transporter Expression in Supraoptic Neurones Suggests a Glutamatergic Phenotype

Ponzio, T. A., Ni, Y., Montana, V., Parpura, V., & Hatton, G. I. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01410.x · Cited by 38 · see citing works

Selective Gene Expression in Magnocellular Neurons in Rat Supraoptic Nucleus

Mutsuga, N., Shahar, T., Verbalis, J. G., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2022-04.2004 · Cited by 36 · see citing works

Neurohypophysial Hormones and Circadian Rhythma

Forsling, M. L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb55562.x · Cited by 34 · see citing works

Kuniomi Ishimori and the first discovery of sleep-inducing substances in the brain

Kubota, K. (1989) · Neuroscience Research · doi:10.1016/0168-0102(89)90041-2 · Cited by 29 · see citing works

Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons

Brown, C. H., RUAN, M., Scott, V. M., Tobin, V. A., & LUDWIG, M. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00419-6 · Cited by 25 · see citing works

The recent progress in research on effects of anesthetics and analgesics on G protein-coupled receptors

Minami, K., & Uezono, Y. (2012) · Journal of Anesthesia · doi:10.1007/s00540-012-1507-2 · Cited by 24 · see citing works

Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement

Bellavance, M.-A., Takatoh, J., Lu, J., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.022 · Cited by 21 · see citing works

Intravenous injection of evans blue labels magnocellular neuroendocrine cells of the rat supraoptic nucleusin situ and after dissociation

Weiss, M. L., & Cobbett, P. J. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90498-q · Cited by 19 · see citing works

Molecular recognition of ketamine by a subset of olfactory G protein–coupled receptors

Ho, J., Perez‐Aguilar, J. M., Gao, L., Saven, J. G., Matsunami, H., & Eckenhoff, R. G. (2015) · Science Signaling · doi:10.1126/scisignal.2005912 · Cited by 17 · see citing works

The Heart of the Brain: The Hypothalamus and Its Hormones

Leng, G. (2018) · Cited by 16 · see citing works

The Biology of General Anesthesia from Paramecium to Primate

Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works

Anesthesia and the neurobiology of consciousness

Mashour, G. A. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.002 · Cited by 127 · see citing works

Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats

Khan, S., Huang, Y., Timuçin, D., Bailey, S., Lee, S., Lopes, J., Gaunce, E., Mosberger, J., Zhan, M., Abdelrahman, B., et al. (2024) · eneuro · doi:10.1523/eneuro.0291-24.2024 · Cited by 30 · see citing works

The Superpowers of Our Sleep

Gaspar, L. S., Santos, B., Barros-Viegas, A. T., et al. (2020) · Frontiers for Young Minds · doi:10.3389/frym.2020.540052

Sleep homeostasis of a monophasic sleep in reptiles

Sena, H., Yamaguchi, S., Matsui, F., et al. (2022) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.96.0_3-b-ss13-3

Sleep medicine, sleep research, and sleep education: a whole life devoted to sleep

Billiard, M. M. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae029

Sleep Extension: Getting as Much Extra Sleep as Possible

Dement, W. C. (2005) · Clinics in Sports Medicine · doi:10.1016/j.csm.2004.12.014 · Cited by 61 · see citing works

"Sleep, little baby, sleep"

J., J. W. (1866) · Notes and Queries · doi:10.1093/nq/s3-x.251.322-c