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Structure and function of the immune system in the spleen
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The spleen is a multitasking secondary lymphoid organ with specialized cells for initiating immunity to blood-borne targets.
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“Human spleens have a different distribution of T cells within germinal centres compared to mice, with humans lacking a clear bridging outer layer.”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [45]
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“The spleen is a peripheral immune organ where adaptive immunity is initiated [62].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [62]
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“The organization of T and B cell zones in the spleen differs significantly between the two species, potentially impacting immune responses(45, 46).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [45]
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“LPS levels in circulation correlate strongly with severity of ALD in both patients and animal models (45), while mice treated with a broad-spectrum antibiotic cocktail are resistant to alcohol-induced liver injury (46).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [45]
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Metadata
- Authors
- Lewis, S. M., Williams, A., & Eisenbarth, S. C.
- Affiliations
- Yale University (US)
- The Jackson Laboratory for Genomic Medicine (US)
- Corresponding author
- Eisenbarth, Stephanie C.
- Venue
- Science Immunology
- Published
- 2019-03-22
- Volume
- 4
- Issue
- 33
- ISSN
- 2470-9468 (ISSN-L)
- PMC
- PMC6495537
- OpenAlex
- W2918621261
- Cited by
- 1,301
- References
- 125
- Citations by year
- 2026: 216 · 2025: 266 · 2024: 250 · 2023: 200 · 2022: 164 · 2021: 120 · 2020: 67 · 2019: 17
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institutes of Health (UL1TR001863)
- National Institute of Allergy and Infectious Diseases (R21AI135221, R01AI108829)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- spleen, secondary lymphoid organs, adaptive immunity, antigen-presenting cells, T cell response, B cell response, hematopoiesis, red blood cell clearance
- MeSH terms
- Animals, Humans, Lymphocytes, Spleen, Adaptive Immunity
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