Cited by 1,301T-cell and B-cell ImmunologyImmunotoxicology and immune responsesImmunotherapy and Immune Responses

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Structure and function of the immune system in the spleen

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Lewis, Steven M., Williams, Adam, Eisenbarth, Stephanie C.·2019·Science Immunology

DOI 10.1126/sciimmunol.aau6085PMC PMC6495537

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Abstract

The spleen is a multitasking secondary lymphoid organ with specialized cells for initiating immunity to blood-borne targets.

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Authors: Lewis, S. M., Williams, A., & Eisenbarth, S. C.
Affiliations: Yale University (US)
The Jackson Laboratory for Genomic Medicine (US)
Corresponding author: Eisenbarth, Stephanie C.
ORCID: Lewis, Steven M.
Williams, Adam
Eisenbarth, Stephanie C.
Venue: Science Immunology
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-03-22
Volume: 4
Issue: 33
ISSN: 2470-9468 (ISSN-L)
DOI: 10.1126/sciimmunol.aau6085
PMC: PMC6495537
OpenAlex: W2918621261
Cited by: 1,301
References: 125
Citations by year: 2026: 216 · 2025: 266 · 2024: 250 · 2023: 200 · 2022: 164 · 2021: 120 · 2020: 67 · 2019: 17
FWCI: 7.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders: National Institutes of Health (UL1TR001863)
National Institute of Allergy and Infectious Diseases (R21AI135221, R01AI108829)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: spleen, secondary lymphoid organs, adaptive immunity, antigen-presenting cells, T cell response, B cell response, hematopoiesis, red blood cell clearance
MeSH terms: Animals, Humans, Lymphocytes, Spleen, Adaptive Immunity

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Structure and function of the immune system in the spleen

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