Cited by 35Diabetes and associated disordersT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Increased islet antigen–specific regulatory and effector CD4 + T cells in healthy individuals with the type 1 diabetes–protective haplotype

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Wen, Xiaomin, Yang, Junbao, James, Eddie, Chow, I-Ting, Reijonen, Helena, Kwok, William W.·2020·Science Immunology

Abstract

The DR1501-DQ6 haplotype confers protection against type 1 diabetes through islet-specific T regs and IL-10–producing T effs .

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Authors
Wen, X., Yang, J., James, E., Chow, I.-T., Reijonen, H., & Kwok, W. W.
Affiliations
  • Benaroya Research Institute (US)
  • City Of Hope National Medical Center (US)
  • University of Washington (US)
Corresponding author
Kwok, William W.
Venue
Science Immunology
Published
2020-02-14
Volume
5
Issue
44
ISSN
2470-9468 (ISSN-L)
OpenAlex
W3006056392
Cited by
35
References
67
Citations by year
2026: 3 · 2025: 5 · 2024: 10 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 4
FWCI
2.49
Type
journal article
Language
en
Open access
Locations
  • Science Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH Office of the Director (DP3 DK097653, DP3 DK106909)
  • Leona M. and Harry B. Helmsley Charitable Trust (2018PG-T1D036)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
type 1 diabetes, islet antigens, regulatory T cells, CD4+ T cells, effector T cells, IL-10, disease protection, HLA-DQ6
MeSH terms
Diabetes Mellitus, Type 1, Haplotypes, Humans, CD4-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Insulin-Secreting Cells, Healthy Volunteers

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