Cited by 111Neuroscience and Neuropharmacology ResearchEpigenetics and DNA MethylationMemory and Neural Mechanisms

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DNA methylation regulates neuronal glutamatergic synaptic scaling

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Meadows, Jarrod P., Guzman-Karlsson, Mikael C., Phillips, Scott, Holleman, Cassie, Posey, Jessica L., Day, Jeremy J., Hablitz, John J., Sweatt, J. David·2015·Science Signaling

DOI 10.1126/scisignal.aab0715PMC PMC4764068

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Abstract

Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.

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Science Signaling Podcast: 23 June 2015
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Self-citation

Authors: Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D.
Affiliations: University of Alabama at Birmingham (US)
Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Corresponding author: Hablitz, John J.
Sweatt, J. David
ORCID: Phillips, Scott
Day, Jeremy J.
Hablitz, John J.
Sweatt, J. David
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-06-23
Volume: 8
Issue: 382
Pages: ra61-ra61
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aab0715
PMC: PMC4764068
OpenAlex: W2104846922
Cited by: 111
References: 76
Citations by year: 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 17 · 2015: 4
FWCI: 7.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Defense Advanced Research Projects Agency (HR0011-12-1-0015)
NIH (P30-NS047466, MH091122, MH57014, DA034681, T32GM008361, T32NS061788)
Evelyn F. McKnight Brain Research Foundation
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: DNA methylation, glutamatergic synapses, synaptic homeostasis, synaptic plasticity, long-term memory, DNA methyltransferase inhibition, RG108, DNMT1, DNMT3A, TET1, glutamate receptors, miniature excitatory postsynaptic currents, transcription, cortical neurons, tetrodotoxin
MeSH terms: DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, Animals, DNA (Cytosine-5-)-Methyltransferases, Neurons, Phthalimides, Synapses, Tetrodotoxin, Transcription, Genetic, Tryptophan, DNA Methylation, Rats, Synaptic Potentials, Gene Knockdown Techniques

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DNA methylation regulates neuronal glutamatergic synaptic scaling

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