The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
DNA methylation regulates neuronal glutamatergic synaptic scaling
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Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.
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“Additionally, inhibiting DNMT activity increases miniature excitatory postsynaptic currents in cultured cortical neurons, suggesting that DNA methylation regulates glutamatergic synaptic strength [ 76 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [76]
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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Activity-dependent scaling of quantal amplitude in neocortical neurons
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HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
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The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System
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Metadata
- Authors
- Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Corresponding author
- Hablitz, John J.
- Sweatt, J. David
- Venue
- Science Signaling
- Published
- 2015-06-23
- Volume
- 8
- Issue
- 382
- Pages
- ra61-ra61
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC4764068
- OpenAlex
- W2104846922
- Cited by
- 111
- References
- 76
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 17 · 2015: 4
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Defense Advanced Research Projects Agency (HR0011-12-1-0015)
- NIH (P30-NS047466, MH091122, MH57014, DA034681, T32GM008361, T32NS061788)
- Evelyn F. McKnight Brain Research Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- DNA methylation, glutamatergic synapses, synaptic homeostasis, synaptic plasticity, long-term memory, DNA methyltransferase inhibition, RG108, DNMT1, DNMT3A, TET1, glutamate receptors, miniature excitatory postsynaptic currents, transcription, cortical neurons, tetrodotoxin
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, Animals, DNA (Cytosine-5-)-Methyltransferases, Neurons, Phthalimides, Synapses, Tetrodotoxin, Transcription, Genetic, Tryptophan, DNA Methylation, Rats, Synaptic Potentials, Gene Knockdown Techniques
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