The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
DNA methylation regulates neuronal glutamatergic synaptic scaling
Open accessAbstract
Epigenetically mediated changes in postsynaptic glutamate receptor expression enable neurons to adjust responsiveness to their environment.
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“Additionally, inhibiting DNMT activity increases miniature excitatory postsynaptic currents in cultured cortical neurons, suggesting that DNA methylation regulates glutamatergic synaptic strength [ 76 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [76]
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
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Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
HDAC2 negatively regulates memory formation and synaptic plasticity
Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644
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Bi, G., & Poo, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.139 · Cited by 1,525
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Epigenomic Measurements in Brain Tissues
Satterlee, J. S. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_148-1
Epigenetic regulators sculpt the plastic brain
Guan, J., Xie, H. B., & Liu, S. (2017) · Frontiers in Biology · doi:10.1007/s11515-017-1465-z
Understanding Huntington's disease using Machine Learning Approaches
Lokhande, S. (2017) · Scholarship - Claremont (Claremont Colleges) · doi:10.5642/kgitd/4
DNA Methyltransferase 1 and 3a Expression in the Frontal Cortex Regulates Palatable Food ConsumptionPreprint
Manjegowda, M. C., Joy-Gaba, J., Wengert, E. R., Saga, A. U., Warthen, D. M., Kuchler, A., Gaykema, R. P. A., Patel, M. K., Sheffield, N. C., & Scott, M. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.23.445176
Role of DNA Methylation in Mechanisms of Anterograde AmnesiaPreprint
Solntseva, S. V., Nikitin, V. P., Kozyrev, S. A., & Nikitin, P. V. (2021) · Research Square · doi:10.21203/rs.3.rs-1113516/v1
Epigenomic Measurements in Brain Tissues
Satterlee, J. S. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_148
Sleep-dependent DNA methylation remodeling in basolateral amygdala fear engrams
Chen, X., Ruan, F., Rodriguez, A. M., Pan, R., Wang, R., Jin, M., 周连艳, Yi, K., Liu, H., Zhou, W., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118190
Metadata
- Authors
- Meadows, J. P., Guzman-Karlsson, M. C., Phillips, S., Holleman, C., Posey, J. L., Day, J. J., Hablitz, J. J., & Sweatt, J. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Evelyn F. McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Corresponding author
- Hablitz, John J.
- Sweatt, J. David
- Venue
- Science Signaling
- Published
- 2015-06-23
- Volume
- 8
- Issue
- 382
- Pages
- ra61-ra61
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC4764068
- OpenAlex
- W2104846922
- Cited by
- 111
- References
- 76
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 17 · 2015: 4
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Defense Advanced Research Projects Agency (HR0011-12-1-0015)
- NIH (P30-NS047466, MH091122, MH57014, DA034681, T32GM008361, T32NS061788)
- Evelyn F. McKnight Brain Research Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- DNA methylation, glutamatergic synapses, synaptic homeostasis, synaptic plasticity, long-term memory, DNA methyltransferase inhibition, RG108, DNMT1, DNMT3A, TET1, glutamate receptors, miniature excitatory postsynaptic currents, transcription, cortical neurons, tetrodotoxin
- MeSH terms
- DNA (Cytosine-5-)-Methyltransferase 1, DNA Methyltransferase 3A, Animals, DNA (Cytosine-5-)-Methyltransferases, Neurons, Phthalimides, Synapses, Tetrodotoxin, Transcription, Genetic, Tryptophan, DNA Methylation, Rats, Synaptic Potentials, Gene Knockdown Techniques
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