The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742 · see citing works

Richness of human gut microbiome correlates with metabolic markers

Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works

Inflammatory links between obesity and metabolic disease

Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works

Inducible Foxp3 ⁺ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

Zhou, L., Lopes, J. E., Chong, M. M. W., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008) · Nature · doi:10.1038/nature06878 · Cited by 1,859 · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

Reciprocal interactions of the intestinal microbiota and immune system

Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

Bile acid metabolites control TH17 and Treg cell differentiation

Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1785-z · Cited by 1,457 · see citing works

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370 · see citing works

Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis

Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,190 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

Regulation and function of mTOR signalling in T cell fate decisions

Chi, H. (2012) · Nature Reviews Immunology · doi:10.1038/nri3198 · Cited by 1,035 · see citing works

Hypoxia-Inducible Factor 1 (HIF-1) Pathway

Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 942 · see citing works

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

Berod, L., Friedrich, C., Nandan, A., Freitag, J., Hagemann, S., Harmrolfs, K., Sandouk, A., Hesse, C., Castro, C. N., Bähre, H., et al. (2014) · Nature Medicine · doi:10.1038/nm.3704 · Cited by 927 · see citing works

Regulation of Immune Responses by mTOR

Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075024 · Cited by 836 · see citing works

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Zeng, H., Yang, K., Cloer, C., Neale, G. A. M., Vogel, P., & Chi, H. (2013) · Nature · doi:10.1038/nature12297 · Cited by 789 · see citing works

HIF1α and metabolic reprogramming in inflammation

Corcoran, S. E., & O'Neill, L. A. J. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84431 · Cited by 789 · see citing works

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

Naugler, W. E., & Karin, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.007 · Cited by 730 · see citing works

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 729 · see citing works

Protection from obesity and diabetes by blockade of TGF-β/smad3 signaling

Yadav, H., Quijano, C., Kamaraju, A. K., Gavrilova, O., Malek, R., Chen, W., Zerfas, P., Zhigang, D., Wright, E. C., Stuelten, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.013 · Cited by 709 · see citing works

Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation

Kim, C. H., Park, J., & Kim, M. (2014) · Immune Network · doi:10.4110/in.2014.14.6.277 · Cited by 704 · see citing works

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

Johnson, M. O., Wolf, M. M., Madden, M. Z., Andrejeva, G., Sugiura, A., Contreras, D. C., Maseda, D., Liberti, M. V., Paz, K. G., Kishton, R. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.001 · Cited by 702 · see citing works

Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M., & Tsuchida, T. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.19 · Cited by 700 · see citing works

Glycolysis – a key player in the inflammatory response

Soto‐Heredero, G., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · FEBS Journal · doi:10.1111/febs.15327 · Cited by 645 · see citing works

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10-164921 · Cited by 610 · see citing works

Germ‐free C57BL/6J mice are resistant to high‐fat‐diet‐induced insulin resistance and have altered cholesterol metabolism

Rabot, S., Membrez, M., Bruneau, A., Gérard, P., Harach, T., Moser, M., Raymond, F., Mansourian, R., & Chou, C. J. (2010) · The FASEB Journal · doi:10.1096/fj.10.164921 · Cited by 610 · see citing works

Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking

Wieman, H. L., Wofford, J. A., & Rathmell, J. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0593 · Cited by 593 · see citing works

Cutting Edge: An In Vivo Requirement for STAT3 Signaling in TH17 Development and TH17-Dependent Autoimmunity

Harris, T. J., Grosso, J. F., Yen, H., Xin, H., Kortylewski, M., Albesiano, E., Hipkiss, E. L., Getnet, D., Goldberg, M. V., Maris, C. H., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4313 · Cited by 585 · see citing works

The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins

McNulty, N. P., Yatsunenko, T., Hsiao, A., Faith, J. J., Muegge, B. D., Goodman, A. L., Henrissat, B., Oozeer, R., Cools-Portier, S., Gobert, G., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002701 · Cited by 544 · see citing works

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Klysz, D., Tai, X., Robert, P. A., Craveiro, M., Cretenet, G., Oburoglu, L., Mongellaz, C., Floess, S., Fritz, V., Matias, M. I., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aab2610 · Cited by 522 · see citing works

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M., Martínez‐Reyes, I., Gao, P., Helmin, K. A., Abdala‐Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 496 · see citing works

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33–LacZ Gene Trap Reporter Strain

Pichery, M., Mirey, E., Mercier, P., Lefrançais, E., Dujardin, A., Ortéga, N., & Girard, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101977 · Cited by 463 · see citing works

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Field, C. S., Baixauli, F., Kyle, R. L., Puleston, D. J., Cameron, A. M., Sanin, D. E., Hippen, K. L., Loschi, M. L., Thangavelu, G., Corrado, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.021 · Cited by 428 · see citing works

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

Jagannathan‐Bogdan, M., McDonnell, M. E., Shin, H., Rehman, Q., Hastürk, H., Apovian, C. M., & Nikolajczyk, B. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002615 · Cited by 418 · see citing works

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

Gomes, A. L., Teijeiro, A., Burén, S., Tummala, K. S., Yilmaz, M., Waisman, A., Theurillat, J.-P., Perna, C., & Djouder, N. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.020 · Cited by 401 · see citing works

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Xu, T., Stewart, K. M., Wang, X., Liu, K., Xie, M., Ryu, J. K., Li, K., Ma, T., Wang, H., Ni, L., et al. (2017) · Nature · doi:10.1038/nature23475 · Cited by 395 · see citing works

IL-17 regulates adipogenesis, glucose homeostasis, and obesity

Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394 · see citing works

Regulatory T Cells in Cancer

Mougiakakos, D., Choudhury, A., Lladser, Á., Kiessling, R. W., & Johansson, C. C. (2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)07003-x · Cited by 392 · see citing works

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation

Raud, B., Roy, D. G., Divakaruni, A. S., Tarasenko, T. N., Franke, R., Ma, E. H., Samborska, B., Hsieh, W. Y., Wong, A., Stüve, P., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.002 · Cited by 389 · see citing works

Molecular pathways in non-alcoholic fatty liver disease

Auguet, T., Berlanga, A., Guiu‐Jurado, E., & Porras, J. A. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s62831 · Cited by 380 · see citing works

Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

Kolodin, D., van Panhuys, N., Li, C., Magnuson, A. M., Cipolletta, D., Miller, C. M., Wagers, A., Germain, R. N., Benoist, C., & Mathis, D. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.005 · Cited by 365 · see citing works

PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ

Kurebayashi, Y., Nagai, S., Ikejiri, A., Ohtani, M., Ichiyama, K., Baba, Y., Yamada, T., Egami, S., Hoshii, T., Hirao, A., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.02.007 · Cited by 323 · see citing works

γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

Kohlgruber, A. C., Gal-Oz, S. T., LaMarche, N. M., Shimazaki, M., Duquette, D., Koay, H.-F., Nguyen, H. N., Mina, A. I., Paras, T., Tavakkoli, A., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0094-2 · Cited by 319 · see citing works

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

Deiuliis, J. A., Shah, Z., Shah, N., NEEDLEMAN, B. J., Mikami, D. J., Narula, V. K., Perry, K. A., Hazey, J. W., Kampfrath, T., Kollengode, M. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016376 · Cited by 314 · see citing works

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.001 · Cited by 303 · see citing works

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

Rau, M., Schilling, A.-K., Meertens, J., Hering, I., Weiss, J., Jurowich, C., Kudlich, T., Hermanns, H. M., Bantel, H., Beyersdorf, N., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501175 · Cited by 302 · see citing works

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

Tang, Y., Bian, Z., Zhao, L., Liu, Y., Liang, S., Wang, Q., Han, X., Peng, Y., Chen, X., Shen, L., et al. (2011) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2011.04471.x · Cited by 294 · see citing works

Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women

Šumarac-Dumanović, M., Stevanović, D., Ljubić, A., Jorga, J. B., Simic, M., Stamenkovic-Pejkovic, D., Starcevic, V. P., Trajković, V., & Micić, D. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.216 · Cited by 287 · see citing works

Association Between Specific Adipose Tissue CD4+ T-Cell Populations and Insulin Resistance in Obese Individuals

Fabbrini, E., Cella, M., McCartney, S. A., Fuchs, A. G., Abumrad, N. A., Pietka, T., Chen, Z., Finck, B. N., Han, D. H., Magkos, F., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.010 · Cited by 280 · see citing works

Hypoxia inducible factor (HIF) function in innate immunity and infection

Zinkernagel, A. S., Johnson, R. S., & Nizet, V. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0282-2 · Cited by 265 · see citing works

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., & Nakayama, T. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.014 · Cited by 253 · see citing works

The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: relationship with metabolic factors and complications

Zeng, C., Shi, X., Zhang, B., Liu, H., Zhang, L., Ding, W., & Zhao, Y. X. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0816-5 · Cited by 248 · see citing works

Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients

Bertola, A., Bonnafous, S., Anty, R., Patouraux, S., Saint-Paul, M.-C., Iannelli, A., Gugenheim, J., Barr, J., Mato, J. M., Le Marchand-Brustel, Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013577 · Cited by 240 · see citing works

Branched short-chain fatty acids modulate glucose and lipid metabolism in primary adipocytes

Heimann, E., NYMAN, M. E., Pålbrink, A.-K., Lindkvist‐Petersson, K., & Degerman, E. (2016) · Adipocyte · doi:10.1080/21623945.2016.1252011 · Cited by 238 · see citing works

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity

Howie, D., Cobbold, S. P., Adams, E., ten Bokum, A., Necula, A. S., Zhang, W., Huang, H., Roberts, D. J., Thomas, B. C., Hester, S., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.89160 · Cited by 218 · see citing works

A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury

Ma, X., Hua, J., Mohamood, A. R., Hamad, A. R. A., Ravi, R. K., & Li, Z. (2007) · Hepatology · doi:10.1002/hep.21823 · Cited by 199 · see citing works

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

Gulen, M. F., Kang, Z., Bulek, K., Youzhong, W., Kim, T. W., Chen, Y., Altuntas, C. Z., Bak‐Jensen, K. S., McGeachy, M. J., Do, J., et al. (2010) · Immunity · doi:10.1016/j.immuni.2009.12.003 · Cited by 197 · see citing works

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival

Howie, D., ten Bokum, A., Necula, A. S., Cobbold, S. P., & Waldmann, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01949 · Cited by 187 · see citing works

IL-17 in obesity and adipogenesis

Ahmed, M., & Gaffen, S. L. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.10.005 · Cited by 186 · see citing works

Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Matés, J. M., Paola, F. J. D., Campos-Sandoval, J. A., Mazurek, S., & Márquez, J. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.012 · Cited by 164 · see citing works

Microbial Reprogramming Inhibits Western Diet-Associated Obesity

Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068596 · Cited by 164 · see citing works

The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice

Rolla, S., Alchera, E., Imarisio, C., Bardina, V., Valente, G., Cappello, P., Mombello, C., Follenzi, A., Novelli, F., & Carini, R. (2016) · Clinical Science · doi:10.1042/cs20150405 · Cited by 158 · see citing works

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes

Nicholas, D., Proctor, E. A., Agrawal, M., Belkina, A. C., Nostrand, S. C. V., Bharath, L. P., Jones, A. R., Raval, F., Ip, B. C., Zhu, M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.004 · Cited by 155 · see citing works

Metabolism Controls the Balance of Th17/T-Regulatory Cells

Sun, L., Fu, J., & Zhou, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01632 · Cited by 152 · see citing works

Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity

Peng, H., Lucavs, J., Ballard, D. J., Das, J. K., Kumar, A., Wang, L., Ren, Y., Xiong, X., & Song, J. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652687 · Cited by 140 · see citing works

Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes

Shin, J. H., Shin, D. W., & Noh, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.008 · Cited by 133 · see citing works

Th17 cytokines differentiate obesity from obesity‐associated type 2 diabetes and promote TNF α production

Ip, B. C., Cilfone, N. A., Belkina, A. C., DeFuria, J., Jagannathan‐Bogdan, M., Zhu, M., Kuchibhatla, R., McDonnell, M. E., Xiao, Q., Kepler, T. B., et al. (2015) · Obesity · doi:10.1002/oby.21243 · Cited by 128 · see citing works

The imbalance of Th17/Treg cells is involved in the progression of nonalcoholic fatty liver disease in mice

He, B., Wu, L., Xie, W., Shao, Y., Jiang, J., Zhao, Z., Yan, M., Chen, Z., & Cui, D. (2017) · BMC Immunology · doi:10.1186/s12865-017-0215-y · Cited by 126 · see citing works

Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells

Kono, M., Yoshida, N., Maeda, K., & Tsokos, G. C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714717115 · Cited by 124 · see citing works

The AMP analog AICAR modulates the T reg /T h 17 axis through enhancement of fatty acid oxidation

Gualdoni, G. A., Mayer, K. A., Göschl, L., Boucheron, N., Ellmeier, W., & Zlabinger, G. J. (2016) · The FASEB Journal · doi:10.1096/fj.201600522r · Cited by 121 · see citing works

Molecular control of pathogenic Th17 cells in autoimmune diseases

Wu, B., & Wan, Y. Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106187 · Cited by 118 · see citing works

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction

Schmidleithner, L. M., Thabet, Y., Schönfeld, E., Köhne, M., Sommer, D., Abdullah, Z., Sadlon, T. J., Osei-Sarpong, C., Subbaramaiah, K., Copperi, F., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.014 · Cited by 117 · see citing works

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis

Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., & Divanovic, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149783 · Cited by 116 · see citing works

Adipose Tissue–Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation

Eljaafari, A., Robert, M., Chehimi, M., Chanon, S., Durand, C., Vial, G., Bendridi, N., Madec, A., Disse, E., Laville, M., et al. (2015) · Diabetes · doi:10.2337/db15-0162 · Cited by 113 · see citing works

Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice

Hong, C., Park, A., Yang, B., Yun, C. H., Kwak, M.-J., Lee, G.-W., Kim, J. H., Jang, M. S., Lee, E., Jeun, E.-J., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.02.016 · Cited by 113 · see citing works

‘Repair’ Treg Cells in Tissue Injury

Zhang, C., Li, L., Feng, K., Fan, D., Xue, W., & Lü, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484295 · Cited by 107 · see citing works

T Cell Populations and Functions Are Altered in Human Obesity and Type 2 Diabetes

Touch, S., Clément, K., & André, S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0900-5 · Cited by 105 · see citing works

Activation of Mevalonate Pathway Via LKB1 is Essential for Stability of Treg Cells

Timilshina, M., You, Z., Lacher, S. M., Acharya, S., Jiang, L., Kang, Y., Kim, J., Chang, H. W., Kim, K., Park, B., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.020 · Cited by 103 · see citing works

Obesity and chronic inflammation crosslinking

Artemniak-Wojtowicz, D., Kucharská, A., & Pyrżak, B. (2021) · Central European Journal of Immunology · doi:10.5114/ceji.2020.103418 · Cited by 103 · see citing works

Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation

Kono, M., Maeda, K., Stocton-Gavanescu, I., Pan, W., Umeda, M., Katsuyama, E., Burbano, C., Orite, S. Y. K., Vukelic, M., Tsokos, M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127395 · Cited by 101 · see citing works

Targeting T Cell Activation and Lupus Autoimmune Phenotypes by Inhibiting Glucose Transporters

Li, W., Qu, G., Choi, S., Cornaby, C., Titov, A. A., Kanda, N., Teng, X., Wang, H., & Morel, L. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00833 · Cited by 100 · see citing works

The obesity-related pathology and Th17 cells

Endo, Y., Yokote, K., & Nakayama, T. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2399-3 · Cited by 98 · see citing works

IL-17 Axis Driven Inflammation in Non-Alcoholic Fatty Liver Disease Progression

Giles, D. A., Moreno‐Fernandez, M. E., & Divanovic, S. (2015) · Current Drug Targets · doi:10.2174/1389450116666150531153627 · Cited by 98 · see citing works

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21

Kim, E., Lee, S., Jhun, J. Y., Byun, J. K., Jeong, J. H., Lee, S.-Y., Kim, J. K., Choi, J. Y., & Cho, M. (2016) · Mediators of Inflammation · doi:10.1155/2016/5813030 · Cited by 97 · see citing works

A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

Kälin, S., Becker, M., Ott, V. B., Serr, I., Hosp, F., Mollah, M. M. H., Keipert, S., Lamp, D., Rohner‐Jeanrenaud, F., Flynn, V. K., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.008 · Cited by 96 · see citing works

Maintenance DNA methylation is essential for regulatory T cell development and stability of suppressive function

Helmin, K. A., Morales‐Nebreda, L., Acosta, M. A. T., Anekalla, K. R., Chen, S.-Y., Abdala‐Valencia, H., Politanska, Y., Cheresh, P., Akbarpour, M., Steinert, E. M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137712 · Cited by 95 · see citing works

Faecalibacterium prausnitzii produces butyrate to decrease c-Myc-related metabolism and Th17 differentiation by inhibiting histone deacetylase 3

Zhang, M., Zhou, L., Wang, Y., Dorfman, R. G., Tang, D., Xu, L., Pan, Y., Zhou, Q., Li, Y., Yin, Y., et al. (2019) · International Immunology · doi:10.1093/intimm/dxz022 · Cited by 94 · see citing works

The role of Th17 and Treg responses in the pathogenesis of RSV infection

Mangodt, T. C., Herck, M. A. V., Nullens, S., Ramet, J., Dooy, J. J. D., Jorens, P. G., & Winter, B. Y. D. (2015) · Pediatric Research · doi:10.1038/pr.2015.143 · Cited by 90 · see citing works

HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance

Chuang, H., Sheu, W. H., Lin, Y.-T., Tsai, C.-Y., Yang, C. Y., Cheng, Y.-J., Huang, P. Y., Li, J.-P., Chiu, L.-L., Wang, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms5602 · Cited by 88 · see citing works

IL-17A Induces Pro-Inflammatory Cytokines Production in Macrophages via MAPKinases, NF-κB and AP-1

Chen, J., Liao, M., Gao, X., Zhong, Q., Tang, T., Yu, X., Liao, Y., & Cheng, X. C. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000354525 · Cited by 84 · see citing works

A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A pathway

Bao, L., Yin, J., Gao, W., Wang, Q., Yao, W., & Gao, X.-D. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14383 · Cited by 83 · see citing works

Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial

Lalazar, G., Mizrahi, M., Turgeman, I., Adar, T., Yaʼacov, A. B., Shabat, Y., Assy, N., Hemed, N., Zolotarovya, L., Lichtenstein, Y., et al. (2015) · Journal of Clinical Immunology · doi:10.1007/s10875-015-0160-6 · Cited by 77 · see citing works

Metformin mitigates autoimmune insulitis by inhibiting Th1 and Th17 responses while promoting Treg production.

Wu, D., Ding, Y., Yu, X., Ma, D., Yang, B., Li, Y., Huang, L., Chen, Z., Zheng, J., & Yang, C. (2019) · PubMed Central · Cited by 77 · see citing works

A Unique Population: Adipose-Resident Regulatory T Cells

Zeng, Q., Sun, X., Xiao, L., Xie, Z., Bettini, M., & Deng, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02075 · Cited by 69 · see citing works

Metabolic regulation of TH17 cells

Shen, H., & Shi, L. Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.03.005 · Cited by 68 · see citing works

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

Mailer, R. K., Gisterå, A., Polyzos, K. A., Ketelhuth, D. F. J., & Hansson, G. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-15546-8 · Cited by 67 · see citing works

Conserved Intergenic Elements and DNA Methylation Cooperate to Regulate Transcription at the il17 Locus

Thomas, R. M., Sai, H., & Wells, A. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351916 · Cited by 65 · see citing works

The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists

Miao, Y., Zheng, Y., Geng, Y., Yang, L., Cao, N., Dai, Y., & Wei, Z. (2021) · Theranostics · doi:10.7150/thno.54803 · Cited by 65 · see citing works

Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver

Mailer, R., Gisterå, A., Polyzos, K., Ketelhuth, D., & Hansson, G. (2017) · Circulation Research · doi:10.1161/circresaha.116.310054 · Cited by 63 · see citing works

Regulatory T Cell Heterogeneity in the Thymus: Impact on Their Functional Activities

Santamaria, J. C., Borelli, A., & Irla, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643153 · Cited by 63 · see citing works

Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway

Chen, Y., Li, Z., Li, H., Su, W., Xie, Y., Pan, Y., Chen, X., & Liang, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.581673 · Cited by 61 · see citing works

Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis

Steinz, M. M., Persson, M., Aresh, B., Olsson, K., Cheng, A. J., Ahlstrand, E., Lilja, M. R., Lundberg, T. R., Rullman, E., Möller, K. Ä., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126347 · Cited by 60 · see citing works

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

SU, W. W., Chapman, N. M., Wei, J., Zeng, H., Dhungana, Y., Shi, H., Saravia, J., Zhou, P., Long, L., Rankin, S. L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.022 · Cited by 60 · see citing works

3, 3′-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance

Liu, Y., She, W., Wang, F., Li, J., Wang, J., & Jiang, W. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.09.024 · Cited by 59 · see citing works

HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival

Lacher, S. M., Bruttger, J., Kalt, B., Berthelet, J., Rajalingam, K., Wörtge, S., & Waisman, A. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.221 · Cited by 58 · cited 2× · see citing works

Epigallocatechin-3-gallate ameliorates both obesity and autoinflammatory arthritis aggravated by obesity by altering the balance among CD4+ T-cell subsets

Byun, J. K., Yoon, B., Jhun, J., Oh, H.-J., Kim, E.-K., Min, J., & Cho, M. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.11.006 · Cited by 56 · see citing works

Different Th17 immunity in gut, liver, and adipose tissues during obesity: the role of diet, genetics, and microbes

Cavallari, J. F., Denou, E., Foley, K. P., Khan, W. I., & Schertzer, J. D. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1127481 · Cited by 55 · see citing works

Metabolic regulation of T cell differentiation and function

Park, B. V., & Pan, F. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.07.027 · Cited by 54 · see citing works

Fatty acid oxidation

Green, D. E. (1963) · Progress in the Chemistry of Fats and other Lipids · doi:10.1016/0079-6832(63)90020-x · Cited by 54 · see citing works

Expression of CD4+CD25+Foxp3+ Regulatory T Cells, Interleukin 10 and Transforming Growth Factor β in Newly Diagnosed Type 2 Diabetic Patients

Yuan, N., Zhang, H., Qi, W., Wang, P., & Guo, W. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-113454 · Cited by 53 · see citing works

OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis.

Sun, G.-Y., Jin, H., Zhang, C.-P., Meng, H., Zhao, X.-Y., Wei, D., Ou, X.-J., Wang, Q.-Y., Li, S.-X., Wang, T., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.12.006 · Cited by 48 · see citing works

Impaired CD4+ and T-helper 17 cell memory response to Streptococcus pneumoniae is associated with elevated glucose and percent glycated hemoglobin A1c in Mexican Americans with type 2 diabetes mellitus

Martinez, P. J., Mathews, C. E., Actor, J. K., Hwang, S., Brown, E. L., Santiago, H. L. P. K.-D., Hoch, S. P. F., McCormick, J. B., & Mirza, S. (2013) · Translational research · doi:10.1016/j.trsl.2013.07.005 · Cited by 47 · see citing works

Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis

Söderberg, C., Marmur, J., Eckes, K., Glaumann, H., Sällberg, M., Frelin, L., Rosenberg, P. M., Stal, P. I., & Hultcrantz, R. W. (2011) · Apmis · doi:10.1111/j.1600-0463.2011.02746.x · Cited by 46 · see citing works

Nonalcoholic fatty liver disease: Synopsis of current developments

Onyekwere, C. A., Ogbera, A. O., Samaila, A. A., Balogun, B., & Abdulkareem, F. B. (2015) · Nigerian Journal of Clinical Practice · doi:10.4103/1119-3077.163288 · Cited by 46 · see citing works

Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Gilleron, J., Bouget, G., Ivanov, S., Méziat, C., Ceppo, F., Vergoni, B., Djedaini, M., Soprani, A., Dumas, K., Jacquel, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.083 · Cited by 46 · see citing works

Intrahepatic Innate Lymphoid Cells Secrete IL-17A and IL-17F That Are Crucial for T Cell Priming in Viral Infection

Jie, Z., Liang, Y., Hou, L., Dong, C., Iwakura, Y., Soong, L., Cong, Y., & Sun, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303281 · Cited by 43 · see citing works

Mesenteric lymph node CD4+ T lymphocytes migrate to liver and contribute to non-alcoholic fatty liver disease

Su, L. C., Wu, Z., Chi, Y., Song, Y., Xu, J., Tan, J., Xu, C., & Liu, Y. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2019.01.005 · Cited by 43 · see citing works

Sitagliptin, a DPP-4 inhibitor, alters the subsets of circulating CD4+ T cells in patients with type 2 diabetes

Aso, Y., Fukushima, M., Sagara, M., Jojima, T., Iijima, T., Suzuki, K., Momobayashi, A., Kasai, K., & Inukai, T. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.10.012 · Cited by 43 · see citing works

Acute haemodynamic changes during haemodialysis do not exacerbate gut hyperpermeability

Wong, J., Lenaerts, K., Meesters, D. M., Damink, S. W. M. O., van Eijk, H. M. H., Vilar, E., & Farrington, K. (2019) · Bioscience Reports · doi:10.1042/bsr20181704 · Cited by 38 · see citing works

Role of alteration in Treg/Th17 cells’ balance in nephropathic patients with Type 2 diabetes mellitus

Abouzeid, S., & Sherif, N. (2015) · Electronic physician · doi:10.19082/1613 · Cited by 38 · see citing works

Antiobesity Effect of a Small Molecule Repressor of RORγ

Chang, M. R., He, Y., Khan, T. M., Kuruvilla, D. S., Garcia-Ordoñez, R. D., Corzo, C. A., Unger, T. J., White, D. W., Khan, S., Lin, L., et al. (2015) · Molecular Pharmacology · doi:10.1124/mol.114.097485 · Cited by 34 · see citing works

Striking a Balance with Help from our Little Friends - How the Gut Microbiota Contributes to Immune Homeostasis.

Arnolds, K. L., & Lozupone, C. (2016) · PubMed Central · Cited by 33 · see citing works

Mevalonate promotes differentiation of regulatory T cells

Acharya, S., Timilshina, M., & Chang, J. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01784-y · Cited by 32 · see citing works

Th17 and regulatory T cells in patients with different time of progression of type 2 diabetes mellitus

Guzmán‐Flores, J. M., Ramı́rez-Emiliano, J., Pérez‐Vázquez, V., & López-Briones, S. (2020) · Central European Journal of Immunology · doi:10.5114/ceji.2020.94670 · Cited by 32 · see citing works

OX40 promotes obesity-induced adipose inflammation and insulin resistance

Liu, B., Yu, H., Sun, G., Sun, X., Jin, H., Zhang, C., Shi, W., Tian, D., Liu, K., Xu, H., et al. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2552-7 · Cited by 30 · see citing works

Effect of redox status of peripheral blood on immune signature of circulating regulatory and cytotoxic T cells in streptozotocin induced rodent model of type I diabetes

Anupam, K., Kaushal, J., Prabhakar, N., & Bhatnagar, A. (2018) · Immunobiology · doi:10.1016/j.imbio.2018.07.004 · Cited by 30 · see citing works

Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice

Van Herck, M. A., Vonghia, L., Kwanten, W. J., Vanwolleghem, T., Ebo, D. G., Michielsen, P. P., De Man, J. G., Gama, L., De Winter, B. Y., & Francque, S. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01711 · Cited by 30 · see citing works

IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes

Shinjo, T., Iwashita, M., Yamashita, A., Sano, T., Tsuruta, M., Matsunaga, H., Sanui, T., Asano, T., & Nishimura, F. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.049 · Cited by 29 · see citing works

BxPC-3-Derived Small Extracellular Vesicles Induce FOXP3+ Treg through ATM-AMPK-Sirtuins-Mediated FOXOs Nuclear Translocations

Shen, T., Jia, S., Ding, G., Ping, D., Zhou, L., Zhou, S., & Cao, L. (2020) · iScience · doi:10.1016/j.isci.2020.101431 · Cited by 29 · see citing works

Elevated levels of Th17 cells in children with central obesity

Łuczyński, W., Grubczak, K., Moniuszko, M., Głowińska‐Olszewska, B., & Bossowski, A. T. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2015.1066845 · Cited by 28 · see citing works

Dysregulation of circulating CD 4+ CXCR 5+ T cells in type 2 diabetes mellitus

Wang, Q., Zhai, X., Chen, X., Lu, J., Zhang, Y., & Huang, Q. (2014) · Apmis · doi:10.1111/apm.12330 · Cited by 28 · see citing works

A High Frequency of Peripheral Blood IL‐22+CD4+ T Cells in Patients With New Onset Type 2 Diabetes Mellitus

Guo, H., Xu, B., Yang, X., Peng, D., Wang, Y., Liu, X., Cui, C., & Jiang, Y. (2014) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.21821 · Cited by 27 · see citing works

Chronic intermittent hypoxia promotes the development of experimental non-alcoholic steatohepatitis by modulating Treg/Th17 differentiation

Liu, J., Li, W., Zhu, W., He, W., Zhao, H., Yu, X., Liu, C., & Wu, W. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmy131 · Cited by 24 · see citing works

Reviewing the impact of lipid synthetic flux on Th17 function

Kidani, Y., & Bensinger, S. J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.03.012 · Cited by 23 · see citing works

IL-17A contributes to propagation of inflammation but does not impair adipogenesis and/or insulin response, in adipose tissue of obese individuals

Pestel, J., Chehimi, M., Bonhomme, M., Robert, M., Vidal, H., & Eljaafari, A. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154865 · Cited by 22 · see citing works

The energy sensor AMPK orchestrates metabolic and translational adaptation in expanding T helper cells

Mayer, K. A., Smole, U., Zhu, C., Derdak, S. V., Minervina, A. A., Salnikova, M. A., Witzeneder, N., Christamentl, A., Boucheron, N., Waidhofer‐Söllner, P., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202001763rr · Cited by 17 · see citing works

Glycyrrhizin, a High-Mobility Group Box 1 Inhibitor, Improves Lipid Metabolism and Suppresses Vascular Inflammation in Apolipoprotein E Knockout Mice

Ding, J., Luo, C.-Y., Wang, X., Zhou, T., Zheng, X., Zhang, Z., Yu, B., Zhang, J., & Tong, X.-H. (2018) · Journal of Vascular Research · doi:10.1159/000495310 · Cited by 17 · see citing works

An Integrative Network Modeling Approach to T CD4 Cell Activation

Martínez-Méndez, D., Villarreal, C., Mendoza, L., & Huerta, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00380 · Cited by 16 · see citing works

Diminished levels of regulatory T cell subsets (CD8+Foxp3, CD4+Foxp3 and CD4+CD39+Foxp3) but increased Foxp3 expression in adipose tissue from overweight subjects

Ruiz, A. N., Cortés-García, J. D., Cortez-Espinosa, N., Herrera-Rojas, P. I., Ruiz-Rodríguez, V. M., Salgado‐Bustamante, M., García-Hernández, M. H., Reynaga-Hernández, E., Martínez-Jiménez, V., & Portales‐Pérez, D. P. (2016) · Nutrition · doi:10.1016/j.nut.2016.02.006 · Cited by 16 · see citing works

A guanidine‐rich regulatory oligodeoxynucleotide improves type‐2 diabetes in obese mice by blocking T‐cell differentiation

Cheng, X. C., Wang, J., Xia, N., Yan, X., Tang, T., Chen, H., Zhang, H.-M., Liu, J., Kong, W., Sjöberg, S., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201272 · Cited by 13 · see citing works

Electromagnetic Fields Ameliorate Insulin Resistance and Hepatic Steatosis by Modulating Redox Homeostasis and SREBP-1c Expression in db/db Mice

Zhai, M., Yan, X., Liu, J., Long, Z., Zhao, S., Li, W., Liu, Y., & Hai, C. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s294020 · Cited by 7 · see citing works

Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

Hu, T., Liu, C., Lei, M., Zeng, Q., Li, L., Tang, H., & Zhang, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01954-6 · Cited by 425 · see citing works

The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

Wen, Y., Wang, Y., Zhao, C., Zhao, B., & Wang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119317 · Cited by 238 · see citing works

Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential

Wang, L., Liang, Y., Zhao, C., Ma, P., Zeng, S., Ju, D., Zhao, M., Yu, M., & Shi, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02326-4 · Cited by 177 · see citing works

Diabetes mellitus promotes susceptibility to periodontitis—novel insight into the molecular mechanisms

Zhao, M., Xie, Y., Gao, W., Li, C., Ye, Q., & Li, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1192625 · Cited by 111 · see citing works

The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis

Fakharian, F., Thirugnanam, S., Welsh, D. A., Kim, W., Rappaport, J., Bittinger, K. L., & Rout, N. (2023) · Microorganisms · doi:10.3390/microorganisms11071849 · Cited by 93 · see citing works

Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease

Gao, H., Jiang, Y., Zeng, G., Huda, N., Thoudam, T., Yang, Z.-H., Liangpunsakul, S., & Ma, J. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100104 · Cited by 85 · see citing works

Molecular and Pathophysiological Links between Metabolic Disorders and Inflammatory Bowel Diseases

Hyun, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179139 · Cited by 84 · see citing works

Novel Insight into the Mechanisms of the Bidirectional Relationship between Diabetes and Periodontitis

Barutta, F., Bellini, S., Durazzo, M., & Gruden, G. (2022) · Biomedicines · doi:10.3390/biomedicines10010178 · Cited by 83 · see citing works

Inflammation, Hyperglycemia, and Adverse Outcomes in Individuals With Diabetes Mellitus Hospitalized for COVID-19

Vasbinder, A. L., Anderson, E. L., Shadid, H. R., Berlin, H. P., Pan, M. M., Azam, T. U., Khaleel, I., Padalia, K. J., Meloche, C., O’Hayer, P., et al. (2022) · Diabetes Care · doi:10.2337/dc21-2102 · Cited by 77 · see citing works

Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies?

Kumar, M., Yip, L., Wang, F., Marty, S., & Fathman, C. G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626082 · Cited by 71 · see citing works

The role of Th/Treg immune cells in osteoarthritis

Wen, Z. H., Qiu, L., Ye, Z., Tan, X., Xu, X., Lu, M., & Kuang, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1393418 · Cited by 63 · see citing works

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Li, G., Wan, Y., Jiao, A., Jiang, K., Cui, G., Tang, J., Yu, S., Hu, Z., Zhao, S., Yi, Z., et al. (2025) · Med Research · doi:10.1002/mdr2.70007 · Cited by 63 · see citing works

Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells

Calvo‐Barreiro, L., Zhang, L., Abdel‐Rahman, S. A., Naik, S. P., & Gabr, M. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021806 · Cited by 61 · see citing works

The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health

Tyagi, A., & Kumar, V. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04395-7 · Cited by 60 · see citing works

Targeting CXCL9/10/11–CXCR3 axis: an important component of tumor-promoting and antitumor immunity

Pan, M., Wei, X., Xiang, X., Liu, Y., Zhou, Q., & Yang, W.-B. (2023) · Clinical & Translational Oncology · doi:10.1007/s12094-023-03126-4 · Cited by 56 · see citing works

Beneficial Effects of Omega-3 Fatty Acids on Obesity and Related Metabolic and Chronic Inflammatory Diseases

Jerab, D., Blangero, F., da Costa, P. C. T., Alves, J. L. D. B., Kéfi, R., Jamoussi, H., Morio, B., & Eljaafari, A. (2025) · Nutrients · doi:10.3390/nu17071253 · Cited by 55 · see citing works

Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis

Xiao, Q., Zhong, Y., Kang, Z.-P., Huang, J., Fang, W., Wei, S., Long, J., Li, S., Zhao, H., & Liu, D. (2022) · Phytotherapy Research · doi:10.1002/ptr.7404 · Cited by 52 · see citing works

Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

Wang, X.-X., Sun, B., Wang, Y., Gao, P., Song, J., Chang, W., Xiao, Z., Xi, Y., Li, Z., An, F.-Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1333993 · Cited by 59 · see citing works

The Interplay Between Immunity, Inflammation and Endothelial Dysfunction

Chee, Y. J., Dalan, R., & Cheung, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041708 · Cited by 51 · see citing works

Epigenetic regulation of human FOXP3+ Tregs: from homeostasis maintenance to pathogen defense

Yue, Y., Ren, Y., Lu, C., Li, P., & Zhang, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1444533 · Cited by 51 · see citing works

Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization

Hui, Y., Xu, Z., Li, J., Kuang, L., Zhong, Y., Tang, Y., Wei, J., Zhou, H., & Zheng, T. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155340 · Cited by 48 · see citing works

Gut microbiota-derived metabolites modulate Treg/Th17 balance: novel therapeutic targets in autoimmune diseases

Li, G., Xiong, Y., Li, Z., Yu, Q., Li, S., Xie, J., Zeng, S., Yu, D., Yang, Y., & Yu, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1710733 · Cited by 44 · see citing works

Ozone Pollution, Oxidative Stress, Regulatory T Cells and Antioxidants

Rivas-Arancibia, S., Hernández-Orozco, E., Rodrı́guez-Martı́nez, E., Valdés‐Fuentes, M., Cornejo-Trejo, V., Pérez-Pacheco, N., Dorado-Martı́nez, C., Zequeida-Carmona, D., & Caleti, I. E. (2022) · Antioxidants · doi:10.3390/antiox11081553 · Cited by 43 · see citing works

Immuno-metabolic control of the balance between Th17-polarized and regulatory T-cells during HIV infection

Yero, A., Bouassa, R. M., Ancuța, P., Estaquier, J., & Jenabian, M.-A. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.01.001 · Cited by 43 · see citing works

Ceramide signaling in immunity: a molecular perspective

Thakkar, H., Vincent, V., & Chaurasia, B. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02642-2 · Cited by 41 · see citing works

Advances in T Cells Based on Inflammation in Metabolic Diseases

Yu, W.-L., Li, C., Zhang, D., Li, Z.-W., Xia, P.-P., Liu, X., Cai, X., Yang, P., Ling, J., Zhang, J., et al. (2022) · Cells · doi:10.3390/cells11223554 · Cited by 32 · see citing works

Regulatory T-cells: The Face-off of the Immune Balance

Singer, M., Elsayed, A. M., & Husseiny, M. I. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2911377 · Cited by 39 · see citing works

The lncRNA HOTAIR via miR-17-5p is involved in arsenite-induced hepatic fibrosis through regulation of Th17 cell differentiation

Wu, M., Sun, J., Wang, L., Wang, P., Xiao, T., Wang, S., & Liu, Q. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130276 · Cited by 36 · see citing works

FOXO1 regulates Th17 cell-mediated hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury

Ren, H., Chen, Y., Zhu, Z., Xia, J., Liu, S., Hu, Y., Qin, X., Zhang, L., Ding, Y., Xia, S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05879-w · Cited by 34 · see citing works

Metabolic influences on T cell in psoriasis: a literature review

Su, R., Zhao, S., Zhang, J., Cao, M., & Peng, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1279846 · Cited by 34 · see citing works

Prostate Infiltration by Treg and Th17 Cells as an Immune Response to Propionibacterium acnes Infection in the Course of Benign Prostatic Hyperplasia and Prostate Cancer

Radej, S., Szewc, M., & Maciejewski, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168849 · Cited by 34 · see citing works

Naringenin as a natural immunomodulator against T cell-mediated autoimmune diseases: literature review and network-based pharmacology study

Liu, Z., Niu, X., & Wang, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2092054 · Cited by 33 · see citing works

Metabolic drives affecting Th17/Treg gene expression changes and differentiation: impact on immune‐microenvironment regulation

Brescia, C., Audia, S., Pugliano, A., Scaglione, F., Iuliano, R., Trapasso, F., Perrotti, N., Chiarella, E., & Amato, R. (2024) · Apmis · doi:10.1111/apm.13378 · Cited by 31 · see citing works

Distinct hepatic immunological patterns are associated with the progression or inhibition of hepatocellular carcinoma

Mirshahi, F., Aqbi, H. F., Isbell, M., Manjili, S. H., Guo, C., Saneshaw, M., Bandyopadhyay, D., Dozmorov, M. G., Khosla, A., Wack, K., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110454 · Cited by 32 · see citing works

Physicochemical Characteristics and Antidiabetic Properties of the Polysaccharides from Pseudostellaria heterophylla

Liu, Y., Kan, Y., Huang, Y., Jiang, C., Zhao, L., Hu, J., & Pang, W. (2022) · Molecules · doi:10.3390/molecules27123719 · Cited by 31 · see citing works

Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

Zhang, C., Li, Y., Yu, Y., Li, Z., Xu, X., Talifu, Z., Liu, W., Yang, D., Gao, F., Wei, S., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1334828 · Cited by 31 · see citing works

TGF-β Signaling Pathways in the Development of Diabetic Retinopathy

Callan, A., Jha, S., Valdez, L., Baldado, L., & Tsin, A. T. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053052 · Cited by 31 · see citing works

Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease

Chandwaskar, R., Dalal, R., Gupta, S. K., Sharma, A., Parashar, D., Kashyap, V. K., Sohal, J. S., & Tripathi, S. K. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13412 · Cited by 31 · see citing works

Beneficial effects of Dendrobium officinale National Herbal Drink on metabolic immune crosstalk via regulate SCFAs-Th17/Treg

Dong, Y., Zhang, Y.-P., Jiang, X., Xie, Z.-Y., Li, B., Jiang, N.-H., Chen, S., & Lv, G. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155816 · Cited by 28 · see citing works

Immune cell dynamics and their role in cardiac injury: Mechanisms and therapeutic implications

Liu, C., Wu, R., Yang, H., & Yao, Y.-M. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118608 · Cited by 28 · see citing works

Cross-Talk between the Cytokine IL-37 and Thyroid Hormones in Modulating Chronic Inflammation Associated with Target Organ Damage in Age-Related Metabolic and Vascular Conditions

Majnarić, L. T., Bosnić, Z., Štefanić, M., & Wittlinger, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126456 · Cited by 25 · see citing works

Plant-Based Dietary Fibers and Polysaccharides as Modulators of Gut Microbiota in Intestinal and Lung Inflammation: Current State and Challenges

Shen, Y., Song, M., Wu, S., Zhao, H., & Zhang, Y. (2023) · Nutrients · doi:10.3390/nu15153321 · Cited by 24 · see citing works

The critical role of Th17 cells and IL-17A in autoimmune and inflammation-associated neurological diseases: mechanisms and therapeutic perspectives

Lou, I. X., Zhou, H., & Wan, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1656422 · Cited by 25 · see citing works

Th17/Regulatory T-Cell Imbalance and Acute Kidney Injury in Patients with Sepsis

Zhou, X., Yao, J., Lin, J., Liu, J., Dong, L., & Duan, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144027 · Cited by 23 · see citing works

Pathogenesis from Inflammation to Cancer in NASH-Derived HCC

Yu, S., Wang, J., Zheng, H., Wang, R., Johnson, N. L., Li, T., Li, P., Lin, J., Li, Y., Jin, Y., et al. (2022) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s377768 · Cited by 23 · see citing works

The Cardiohepatic Axis in Metabolic Disease

Hakeem, A. N., van Berlo, J. H., & Revelo, X. S. (2025) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2025.05.004 · Cited by 22 · see citing works

The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone

Zi, C., Wang, D., Gao, Y., & He, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1104943 · Cited by 23 · see citing works

Recommendations for nutritional supplements for dry eye disease: current advances

Cong, Y., Zhang, Y., Han, Y., Wu, Y., Wang, D., & Zhang, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1388787 · Cited by 22 · see citing works

Inflammation—Insulin Resistance Crosstalk and the Central Role of Myokines

Dobre, M.-Z., Vîrgolici, B., Stefan, D. C. A., Doicin, I.-C., & Stănescu-Spînu, I.-I. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010060 · Cited by 21 · see citing works

Androgen-Induced Cardiovascular Risk in Polycystic Ovary Syndrome: The Role of T Lymphocytes

Moulana, M. (2023) · Life · doi:10.3390/life13041010 · Cited by 22 · see citing works

The multiple mechanisms and therapeutic significance of rutin in metabolic dysfunction-associated fatty liver disease (MAFLD).

Wang, Q., Zhang, Y.-J., Lu, R., Zhao, Q., & Gao, Y. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106178 · Cited by 22 · see citing works

Exploring the Complex Pathophysiology of Necrotizing Enterocolitis in Preterm Neonates

Li, B., Yeganeh, M., Lee, D., Chusilp, S., Balsamo, F., Ganji, N., Wang, C., Zito, A., Biouss, G., & Pierro, A. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-070224-014223 · Cited by 20 · see citing works

Intestinal microbial composition changes induced by Lactobacillus plantarum GBL 16, 17 fermented feed and intestinal immune homeostasis regulation in pigs

Yu, D. Y., Oh, S.-H., Kim, I. S., Kim, G. I., Kim, J., Moon, Y. S., Jang, J.-C., Lee, S., Jung, J. H., Park, J., et al. (2022) · Journal of Animal Science and Technology · doi:10.5187/jast.2022.e89 · Cited by 20 · see citing works

Targeting post-translational modifications of Foxp3: a new paradigm for regulatory T cell-specific therapy

Riaz, F., Huang, Z., & Pan, F. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1280741 · Cited by 20 · see citing works

Maternal F-53B exposure during pregnancy and lactation induced glucolipid metabolism disorders and adverse pregnancy outcomes by disturbing gut microbiota in mice

Feng, Y., Wu, H., Feng, L., Zhang, R., Feng, X., Wang, W., Xu, H., & Fu, F. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.170130 · Cited by 19 · see citing works

Enhanced stem cell-mediated therapeutic immune modulation with zinc oxide nanoparticles in liver regenerative therapy

Park, N., Kim, K. S., Lee, S.-H., Choi, J. H., & Na, K. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123232 · Cited by 18 · see citing works

Interplay of hypoxia, immune dysregulation, and metabolic stress in pathophysiology of type 1 diabetes

Mittal, R., Lemos, J. R. N., Chapagain, P. P., & Hirani, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1599321 · Cited by 17 · see citing works

Human periodontitis-associated salivary microbiome affects the immune response of diabetic mice

He, J., Shen, X., Fu, D., Yang, Y., Xiong, K., Жао, Л., Xie, H., Pelekos, G., & Li, Y. (2022) · Journal of Oral Microbiology · doi:10.1080/20002297.2022.2107814 · Cited by 16 · see citing works

Role of signaling pathways in the interaction between microbial, inflammation and cancer

Kamdje, A. H. N., Simo, R. T., Dongmo, H. P. F., Bidias, A., & Netongo, P. M. (2023) · Holistic Integrative Oncology · doi:10.1007/s44178-023-00064-7 · Cited by 18 · see citing works

Traditional Chinese medicines and natural products targeting immune cells in the treatment of metabolic-related fatty liver disease

Li, Z., Ouyang, H., & Zhu, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1195146 · Cited by 16 · see citing works

Apolipoprotein C-III itself stimulates the Syk/cPLA2-induced inflammasome activation of macrophage to boost anti-tumor activity of CD8+ T cell

Hu, X., Ding, S., Lu, G., Lin, Z., Liao, L., Xiao, W., Ding, Y., Zhang, Y., Wang, Z., Gong, W., et al. (2023) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-023-03547-8 · Cited by 16 · see citing works

Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial

Li, C., Li, Y., Wang, N., Ge, Z., Wang, J., Ding, B., Bi, Y., Wang, Y., Wang, Y., Peng, Z., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103337 · Cited by 18 · see citing works

Traditional Chinese Medicine formulas-based interventions on colorectal carcinoma prevention: The efficacies, mechanisms and advantages

Tang, X., Min, H., Ren, Y., Ji, M., Yan, X., Zeng, W., Lv, Y., Li, Y., & He, Y. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119008 · Cited by 16 · see citing works

Multifaceted Effects of Subchronic Exposure to Chlorfenapyr in Mice: Implications from Serum Metabolomics, Hepatic Oxidative Stress, and Intestinal Homeostasis

Xiong, Y., Ma, X., He, B., Zhi, J., Liu, X., Wang, P., Zhou, Z., & Liu, D. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09682 · Cited by 15 · see citing works

The Role of Th17/Treg Axis in Retinal Pathology Associated with Diabetes and Treatment Options

Mickael, M., Kubick, N., Miftari, K., Horbańczuk, J. O., Atanasov, A. G., Binçe, K., Religa, P., Kamińska, A., Sacharczuk, M., & Ławiński, M. (2025) · Biology · doi:10.3390/biology14030275 · Cited by 15 · see citing works

In Vitro Immunomodulatory Effects of Inonotus obliquus Extracts on Resting M0 Macrophages and LPS-Induced M1 Macrophages

Shen, D., Feng, Y., Zhang, X., Liu, J., Gong, L., Liao, H., & Li, R. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/8251344 · Cited by 15 · see citing works

Changes of intestinal microbiota and microbiota-based treatments in IBD

Li, Q., Zhou, S., Wang, Y., & Cong, J. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03069-4 · Cited by 15 · see citing works

Systemic immunometabolism and responses to vaccines: insights from T and B cell perspectives

Nettelfield, S., Yu, D., & Cañete, P. F. (2023) · International Immunology · doi:10.1093/intimm/dxad021 · Cited by 15 · see citing works

Mogroside V ameliorates broiler pulmonary inflammation via modulating lung microbiota and rectifying Th17/Treg dysregulation in lipopolysaccharides-induced lung injury

Li, Y., Shen, D., Wang, K., Xue, Y., Liu, J., Li, S., Li, X., & Li, C. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103138 · Cited by 15 · see citing works

Relation of T Cell Profile with Vitamin D Receptor and Vitamin D-Binding Protein Gene Polymorphisms in Atopy

Bastyte, D., Tamašauskienė, L., Stakaitiene, I., Briedė, K., Ugenskienė, R., Valiukevičienė, S., & Gradauskienė, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169021 · Cited by 16 · see citing works

Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes

Ghemiș, L., Goriuc, A., Minea, B., Botnariu, G., Mârțu, M.-A., Ențuc, M., Cioloca, D. P., & Foia, L. G. (2024) · Diagnostics · doi:10.3390/diagnostics14212453 · Cited by 15 · see citing works

Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome

Dutta, B., Tripathy, A., Archana, P. R., & Kamath, S. U. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01837-y · Cited by 14 · see citing works

Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE

Jiang, Y., Gao, R., Ying, Q., Li, X., Dai, Y., Song, A., Liu, H., Hasegawa, T., & Li, M. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05453-3 · Cited by 14 · see citing works

Microenvironment-based immunotherapy in oral cancer: a comprehensive review

Mivehchi, H., Eskandari-Yaghbastlo, A., Ghazanfarpour, M., Ziaei, S., Mesgari, H., Faghihinia, F., Ashtiani, N. Z., & Nabi‐Afjadi, M. (2025) · Medical Oncology · doi:10.1007/s12032-025-02694-5 · Cited by 14 · see citing works

Traditional Chinese Medicine Regulates Th17/Treg Balance in Treating Inflammatory Bowel Disease

Xie, F., Xiong, Q., Li, Y., Yao, C., Wu, R., Wang, Q., Luo, L., Liu, H., & Feng, P. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6275136 · Cited by 14 · see citing works

Artemisinin and Its Derivatives from Molecular Mechanisms to Clinical Applications: New Horizons Beyond Antimalarials

Yi, X., Shi, C., Lu, J., Zhu, Z., Li, M., Pan, Y., Huang, X., Zhang, L., & Liu, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178409 · Cited by 13 · see citing works

A Gut Instinct on Leukaemia: A New Mechanistic Hypothesis for Microbiota-Immune Crosstalk in Disease Progression and Relapse

Pagani, I. S., Poudel, G., & Wardill, H. R. (2022) · Microorganisms · doi:10.3390/microorganisms10040713 · Cited by 13 · see citing works

Cardiovascular diseases and the heart–gut cross talk

Majumder, S., Makwana, R., Shetty, V., Mukherjee, S., & Narayan, P. (2023) · Indian Heart Journal · doi:10.1016/j.ihj.2023.12.003 · Cited by 13 · see citing works

High Interleukin (IL)-6 is Associated with Lower Lung Function and Increased Likelihood of Metabolic Dysfunction in Asthma

ADAIR, D., Bagheri, A. B., Yosef, M., Khalatbari, S. H., Lewis, T. C., Mohan, A., & Lugogo, N. L. (2024) · Pulmonary Therapy · doi:10.1007/s41030-024-00281-z · Cited by 13 · see citing works

New prebiotics by ketone donation

Satoh, T. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.05.001 · Cited by 13 · see citing works

Study on the mechanism of Jieduquyuziyin prescription improving the condition of MRL/lpr mice by regulating T cell metabolic reprogramming through the AMPK/mTOR pathway

Zhu, Q., Han, Y., Li, X., Huang, S., Zhao, K., Xie, Z., Fan, Y., & Zhao, T. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119584 · Cited by 12 · see citing works

Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation

Petrarca, C., & Viola, D. (2023) · Antioxidants · doi:10.3390/antiox12010132 · Cited by 12 · see citing works

Interleukin 35: protective role and mechanism in type 1 diabetes

Zhang, S., Liang, J., Xia, J.-P., Li, L., Zheng, L., Wang, Y., Li, Y., Li, Y., & Lu, Y. (2023) · Central European Journal of Immunology · doi:10.5114/ceji.2023.125043 · Cited by 12 · see citing works

Mechanisms behind the anti-diabetic and anti-obesity effects of seaweeds or macroalgae and their bioactive compounds

Magwaza, S. N., & Islam, M. S. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i11.112847 · Cited by 11 · see citing works

Complex interplay of gut microbiota between obesity and asthma in children

Hu, M., Zhao, X., Liu, Y., Zhou, H., You, Y., & Xue, Z. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1264356 · Cited by 11 · see citing works

Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications

Xie, X., Li, F., Wu, Q., Zeng, C., Chen, X., Wang, W., Zhang, C., & Chen, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1688392 · Cited by 10 · see citing works

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

Tan, Y., Hu, Y., Yang, Y., & Chu, H. (2025) · MedComm · doi:10.1002/mco2.70532 · Cited by 10 · see citing works

Gut microbiota circadian rhythms: a key regulator of immunometabolic homeostasis

Zhao, Z., Wu, S., Wang, T., & Zhao, Y. L. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025220 · Cited by 10 · see citing works

Non-alcoholic fatty liver degree and long-term risk of incident inflammatory bowel disease: A large-scale prospective cohort study

Zhang, Q., Liu, S., Wu, J., Zhu, S., Wu, Y., Wu, S., & Zhang, S. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002859 · Cited by 10 · see citing works

Gut microbe and hepatic macrophage polarization in non-alcoholic fatty liver disease

Chen, Y., Gan, Y., Zhong, H., Liu, Y., Huang, J., Wang, W., & Geng, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1285473 · Cited by 10 · see citing works

Immune cell contribution to vascular complications in diabetes

Ma, L., Zhang, X., Li, Z., & Wang, Q. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1549945 · Cited by 10 · see citing works

Synbiotic Intervention with Inulin and Lactiplantibacillus plantarum LPm77 Attenuates Type 2 Diabetes via Enhanced TUDCA Metabolism and Gut–Liver Axis Modulation

Li, M., Guo, J., Meng, J., Wang, X., Pan, T., Zhao, D., Li, H., Gao, R., Wang, Y., Li, H., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c03515 · Cited by 9 · see citing works

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Najar, M., Rahmani, S., Faour, W. H., Alsabri, S. G., Lombard, C. A., Fayyad‐Kazan, H., Sokal, E. M., Merimi, M., & Fahmi, H. (2024) · Cells · doi:10.3390/cells13020169 · Cited by 9 · see citing works

The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair

Melvin, W. J., Bauer, T. M., Mangum, K. D., Audu, C. O., Shadiow, J., Barrett, E. C., Joshi, A., Moon, J. Y., Bogle, R., Mazumder, P., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.179012 · Cited by 9 · see citing works

Lactic acid bacteria fermented foods: Impact on immune system and consequences over type 2 diabetes mellitus

Ahmad, R., Nnamdi, O. A., Etando, A., Sharma, P., Sinha, S., Chowdhury, K., Rowaiye, A. B., Akter, S., Mou, T. J., Dhingra, S., et al. (2023) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2023.142387 · Cited by 10 · see citing works

Immune response to foreign materials in spinal fusion surgery

Cai, J., Wang, W., Cai, P., & Cao, B. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19950 · Cited by 8 · see citing works

Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation

Jiang, C., Zeng, X., Wang, J., Wu, X., Song, L., Yang, L., Li, Z., Xie, N., Yuan, X., Wei, Z., et al. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60855-7 · Cited by 8 · see citing works

Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge

Wadan, A. S., Moshref, A. S., Emam, A. M., Bakry, Y. G., Khalil, B. O., Chaurasia, A., Ibrahim, R. A. H., Badawy, T., & Mehanny, S. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04025-x · Cited by 8 · see citing works

Obesity and Autoimmunity Epidemic: The Role of Immunometabolism

Colamatteo, A., Fusco, C., Matarese, A., & Matarese, G. (2025) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-111324-122456 · Cited by 10 · see citing works

Small extracellular vesicles secreted from TGF-β1-licensed mesenchymal stromal cells reduce inflammation-associated injury following corneal alkali burn

Donohoe, E., Canning, A., Johnston, E., Moosavizadeh, S., Wang, J., Leahy, M. J., Treacy, O., Ryan, A. E., & Ritter, T. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04504-1 · Cited by 8 · see citing works

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Hu, Y., Zhao, Q., Dai, H., Wu, Y., Tang, X., Zhang, N., Jiang, H., Rui, H., & Liu, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1687755 · Cited by 25 · see citing works

Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients

Wang, M., Chen, F., Wang, J., Zeng, Z., Yang, Q., & Shao, S. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.09.005 · Cited by 99 · see citing works

Increasing Imbalance of Treg/Th17 Indicates More Severe Glucose Metabolism Dysfunction in Overweight/obese Patients

Wen, J., Liu, Q., Liu, M., Wang, B., Li, M., Wang, M., Shi, X., Liu, H., & Wu, J. (2020) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.11.012 · Cited by 18 · see citing works

Regulation of immune metabolism in Th17 and Treg cells

Zoonoses, A. A. (2025) · Figshare · doi:10.6084/m9.figshare.30531095

Metabolic control of the Treg/Th17 axis

Barbi, J. J., Pardoll, D. M., & Pan, F. (2013) · Immunological Reviews · doi:10.1111/imr.12029 · Cited by 215 · see citing works