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The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling

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Sculpting Dendritic Spines during Initiation and Maintenance of Neuropathic Pain

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FMRP Modulates Activity-Dependent Spine Plasticity by Binding Cofilin1 mRNA and Regulating Localization and Local Translation

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LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice

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Social deficits via dysregulated Rac1-dependent excitability control of prefrontal cortical neurons and increased GABA/glutamate ratios

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Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice

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Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel

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A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children

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Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway

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Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice

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Opioid and chemokine regulation of cortical synaptodendritic damage in HIV-associated neurocognitive disorders

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The Role of Protein Arginine Methylation as Post-Translational Modification on Actin Cytoskeletal Components in Neuronal Structure and Function

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Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus

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Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus

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Role of Cyclins and Cytoskeletal Proteins in Endometriosis: Insights into Pathophysiology

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Dendritic spine loss caused by AlCl3 is associated with inhibition of the Rac 1/cofilin signaling pathway

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Proteomic Identification of Phosphorylation-Dependent Septin 7 Interactors that Drive Dendritic Spine Formation

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Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats

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Tactile sensory processing deficits in genetic mouse models of autism spectrum disorder

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Cytoskeletal regulation of synaptogenesis in a model of human fetal brain development

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Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders

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Infantile spasms-linked Nedd4-2 mediates hippocampal plasticity and learning via cofilin signaling

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N-Methyl-D-Aspartate Receptors Mediate Synaptic Plasticity Impairment of Hippocampal Neurons Due to Arsenic Exposure

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FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex

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Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury

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Inhibitors of the p21 Activated Kinases

Sampat, N., & Minden, A. (2018) · Current Pharmacology Reports · doi:10.1007/s40495-018-0132-7 · Cited by 9

A 10-Year Review on Advancements in Identifying and Treating Intellectual Disability Caused by Genetic Variations

Hou, K., & Zheng, X. (2024) · Genes · doi:10.3390/genes15091118 · Cited by 12

Dysfunctions of cellular context-sensitivity in neurodevelopmental learning disabilities

Granato, A., Phillips, W. A., Schulz, J. M., Mototaka Suzuki, A., & Larkum, M. E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105688 · Cited by 8

A common single nucleotide variant in the cytokine receptor-like factor-3 (CRLF3) gene causes neuronal deficits in human and mouse cells

Wilson, A., Barakat, R., Mu, R., Karush, L. L., Gao, Y., Hartigan, K. A., Chen, J., Shu, H., Turner, T. N., Maloney, S. E., et al. (2023) · Human Molecular Genetics · doi:10.1093/hmg/ddad155 · Cited by 7

Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome

Baldwin, A. G., Foley, D., Collins, R. J., Lee, H.-A., Jones, D. H., Wahab, B., Waters, L., Pedder, J., Paine, M., Feng, G. J., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02694 · Cited by 7

Altered hippocampal dendritic spine maturation after hypoxia-induced seizures in neonatal rats

Bell, J. J. L., Handy, M., Nieder, C., Getzfread, M., & Jensen, F. E. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103629 · Cited by 8

Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development

Yamada, S., Mizukoshi, T., Tokunaga, A., & Sakakibara, S. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010438 · Cited by 7

The translation initiating factor eIF4E and arginine methylation underlie G3BP1 function in dendritic spine development of neurons

Dong, R., Li, X., Flores, A. D., & Lai, K. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105029 · Cited by 7

The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome

Briševac, D., Scholz, R., Du, D., Elagabani, M. N., Köhr, G., & Kornau, H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15230 · Cited by 7

Stress Elicits Contrasting Effects on Rac1-Cofilin Signaling in the Hippocampus and Amygdala

Bose, M., Nawaz, M. S., Pal, R., & Chattarji, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.880382 · Cited by 7

RAB1A Regulates Glioma Cellular Proliferation and Invasion Via the mTOR Signaling Pathway and Epithelial–Mesenchymal Transition

Ren, B., Wang, L., Yang, N., Liu, T., Zhao, L., Ma, H., Li, J., Zhang, Y., & Ren, X. (2021) · Future Oncology · doi:10.2217/fon-2021-0116 · Cited by 6

Reaction–Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns

Jia, Y., Zhao, Q., Yin, H., Guo, S., Sun, M., Yang, Z. R., & Zhao, X. (2021) · Frontiers in Neurorobotics · doi:10.3389/fnbot.2021.563682 · Cited by 5

Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2) to induce dendritic spine maturation

Schuldt, C., Khudayberdiev, S., Chandra, B., Linne, U., & Rust, M. B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05393-y · Cited by 5

Design decisions for incorporating spatial and mechanical aspects in models of signaling networks

Bell, M. K., & Rangamani, P. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.03.004 · Cited by 4

TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System

Chang, J., Chen, C., Li, W., & Abumaria, N. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01045-6 · Cited by 4

PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury

Kauer, S. D., Benson, C. A., Carrara, J., Tarafder, A. A., Ibrahim, Y. H., Estacion, M. A., Waxman, S. G., & Tan, A. M. (2024) · The Journal of Physiology · doi:10.1113/jp284976 · Cited by 4

LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice

Wang, X., Wang, L., Bu, Q., Xiao, Y., Zhao, Y., Jiang, L., Dai, Y., Li, H., Liu, H., Chen, Y., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1867-24.2025 · Cited by 3

Melatonin improves synaptic morphological plasticity of adolescent male rats after perinatal BDE-209 exposure via SIRT1-mediated LIMK1 and CREB signaling

Gao, J., Shen, J., Gao, L., Yan, D., Wang, Y., Meng, J., Chen, D., Li, H., & Wu, J. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103331 · Cited by 3

Tetrahydropyrazolopyridinones as a Novel Class of Potent and Highly Selective LIMK Inhibitors

Baldwin, A. G., Foley, D., Jones, D. H., Lee, H.-A., Collins, R. J., Wahab, B., Pedder, J. H., Waters, L., Paine, M., Schino, L., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00974 · Cited by 3

Altered auditory feature discrimination in a rat model of Fragile X Syndrome

Gauthier, D. W., James, N., & Auerbach, B. D. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003248 · Cited by 2

Physiological Activation of Synaptic Rac > PAK Signaling Is Defective in a Mouse Model of Fragile-X Syndrome

Chen, L. Y., Rex, C. S., Babayan, A. H., Kramár, E. A., LYNCH, G. S., Gall, C. M., & Lauterborn, J. C. (2010) · eScholarship (California Digital Library)

Physiological Activation of Synaptic Rac>PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome

Chen, L. Y., Rex, C. S., Babayan, A. H., Kramár, E. A., LYNCH, G. S., Gall, C. M., & Lauterborn, J. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1077-10.2010 · Cited by 142

Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology

Bongmba, O. Y. N., Martinez, L. A., Elhardt, M. E., Butler, K., & Tejada-Simon, M. V. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.020 · Cited by 91

Correcting memory deficits in Fragile X syndrome by targeting Rac1/PAK1 signaling

Martinez, L. A., & Tejada-Simon, M. V. (2016) · The FASEB Journal · doi:10.1096/fasebj.30.1_supplement.707.8

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

Pan, F., Aldridge, G. M., Greenough, W. T., & Gan, W.-B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012496107 · Cited by 208