Cited by 122Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

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Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

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Pyronneau, Alexander, He, Qionger, Hwang, Jee-Yeon, Porch, Morgan, Contractor, Anis, Zukin, R. Suzanne·2017·Science Signaling

DOI 10.1126/scisignal.aan0852PMC PMC5988355

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Abstract

Inhibiting Rac1-PAK-LIMK signaling may restore synaptic function and sensory processing in patients with fragile X syndrome.

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Authors: Pyronneau, A., He, Q., Hwang, J.-Y., Porch, M., Contractor, A., & Zukin, R. S.
Affiliations: Albert Einstein College of Medicine (US)
Northwestern University (US)
Corresponding author: Zukin, R. Suzanne
ORCID: Pyronneau, Alexander
Hwang, Jee-Yeon
Porch, Morgan
Contractor, Anis
Zukin, R. Suzanne
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2017-11-07
Volume: 10
Issue: 504
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aan0852
PMC: PMC5988355
OpenAlex: W2767737184
Cited by: 122
References: 78
Citations by year: 2026: 5 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 10 · 2021: 24 · 2020: 17 · 2019: 14 · 2018: 11 · 2017: 1
FWCI: 7.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (award304400, MH092877, award304548, NS45693, award304549, HD083828, award304565, GM007288)
National Institute of Mental Health (award304564, MH108362, award308817, R21MH104808)
Brain and Behavior Research Foundation (award304558, Distinguished Investigator Grant, award304563, Young Investigator Grant)
McKnight Foundation (award304550)
National Institute of General Medical Sciences (award316793, T32-GM007822)
American Heart Association (award304562, Scientist Development Grant)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: fragile X syndrome, Rac1, cofilin, PAK1, dendritic spines, synaptic function, sensory perception, layer 5 pyramidal neurons, small molecule inhibitors, spine density, FMRP
MeSH terms: Actins, Animals, Disease Models, Animal, Fragile X Syndrome, Neuropeptides, Perception, Phosphorylation, Pyridones, Pyrimidines, Somatosensory Cortex, Synapses, Pyramidal Cells, Mice, Knockout, rac1 GTP-Binding Protein, Dendritic Spines, Cofilin 1, Mice, p21-Activated Kinases

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Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

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