The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome
Open accessAbstract
Inhibiting Rac1-PAK-LIMK signaling may restore synaptic function and sensory processing in patients with fragile X syndrome.
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“Rac1 has been identified as a converging factor downstream of numerous proteins encoded by high-risk ASD genes, such as SHANK 4–6, FMR1 (fragile X mental retardation-1) 7, 8, NRXN 9, and AUTS2 10.”
From Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. (2021) · cites this paper as [7]
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Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
Arber, S., Barbayannis, F. A., Hanser, H., Schneider, C., Stanyon, C. A., Bernard, O., & Caroni, P. (1998) · Nature · doi:10.1038/31729 · Cited by 1,426
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E., & Mizuno, K. (1998) · Nature · doi:10.1038/31735 · Cited by 1,296
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.
Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831
Actin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815
Niwa, R., Nagata-Ohashi, K., Takeichi, M., Mizuno, K., & Uemura, T. (2002) · Cell · doi:10.1016/s0092-8674(01)00638-9 · Cited by 694
A critical period for long-term potentiation at thalamocortical synapses
Crair, M. C., & Malenka, R. C. (1995) · Nature · doi:10.1038/375325a0 · Cited by 691
Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627
Rogers, S. J., Hepburn, S., & Wehner, E. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000006000.38991.a7 · Cited by 609
Abnormal Development of Dendritic Spines in FMR1 Knock-Out Mice
Nimchinsky, E. A., Oberlander, A. M., & Svoboda, K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05139.2001 · Cited by 560
Cited by
Sorted by citations
A synaptic perspective of fragile X syndrome and autism spectrum Disorders.
Bagni, C., & Zukin, R. S. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.041 · Cited by 326
Self-citationActivation of autophagy rescues synaptic and cognitive deficits in fragile X mice
Yan, J., Porch, M. W., Court-Vazquez, B. L., Bennett, M. V. L., & Zukin, R. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808247115 · Cited by 146
Self-citationSawicka, K., Hale, C. R., Park, C. Y., Fak, J. J., Gresack, J. E., Driesche, S. J. V., Kang, J. J., Darnell, J. C., & Darnell, R. B. (2019) · eLife · doi:10.7554/elife.46919 · Cited by 118
ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
Licznerski, P., Park, H., Rolyan, H., Chen, R., Mnatsakanyan, N., Miranda, P., Graham, M. M., Wu, J., Cruz-Reyes, N., Mehta, N. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.008 · Cited by 119
Banerjee, A., Ifrim, M. F., Valdez‐Sinon, A. N., Raj, N., & Bassell, G. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.008 · Cited by 111
Metadata
- Authors
- Pyronneau, A., He, Q., Hwang, J.-Y., Porch, M., Contractor, A., & Zukin, R. S.
- Affiliations
- Albert Einstein College of Medicine (US)
- Northwestern University (US)
- Corresponding author
- Zukin, R. Suzanne
- Venue
- Science Signaling
- Published
- 2017-11-07
- Volume
- 10
- Issue
- 504
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC5988355
- OpenAlex
- W2767737184
- Cited by
- 122
- References
- 78
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 10 · 2021: 24 · 2020: 17 · 2019: 14 · 2018: 11 · 2017: 1
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award304400, MH092877, award304548, NS45693, award304549, HD083828, award304565, GM007288)
- National Institute of Mental Health (award304564, MH108362, award308817, R21MH104808)
- Brain and Behavior Research Foundation (award304558, Distinguished Investigator Grant, award304563, Young Investigator Grant)
- McKnight Foundation (award304550)
- National Institute of General Medical Sciences (award316793, T32-GM007822)
- American Heart Association (award304562, Scientist Development Grant)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- fragile X syndrome, Rac1, cofilin, PAK1, dendritic spines, synaptic function, sensory perception, layer 5 pyramidal neurons, small molecule inhibitors, spine density, FMRP
- MeSH terms
- Actins, Animals, Disease Models, Animal, Fragile X Syndrome, Neuropeptides, Perception, Phosphorylation, Pyridones, Pyrimidines, Somatosensory Cortex, Synapses, Pyramidal Cells, Mice, Knockout, rac1 GTP-Binding Protein, Dendritic Spines, Cofilin 1, Mice, p21-Activated Kinases
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