Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

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NAD+ metabolism in health and disease

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Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

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Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

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Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock

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Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2

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Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)

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Free-Running Activity Rhythms in the Rat: Entrainment by Melatonin

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Melatonin is a potent modulator of dopamine release in the retina

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Putative Melatonin Receptors in a Human Biological Clock

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Mammalian melatonin receptors: molecular biology and signal transduction

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Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores.

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PDZ Domain Binding Selectivity Is Optimized Across the Mouse Proteome

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Selective MT 2 melatonin receptor antagonists block melatonin‐mediated phase advances of circadian rhythms

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Myristoylation

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Melatonin and the pineal gland: influence on mammalian seasonal and circadian physiology

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Neuroendocrine rhythms and sleep in aging men

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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

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Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor

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Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer

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Melatonin: Characteristics, Concerns, and Prospects

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Melatonin receptors and their regulation: biochemical and structural mechanisms

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Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins

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Development and validation of a melatonin radioimmunoassay using radioiodinated melatonin as tracer

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Activation of MT2melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock

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Molecular tools to study melatonin pathways and actions.

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Melatonin Action and Signal Transduction in the Rat Suprachiasmatic Circadian Clock: Activation of Protein Kinase C at Dusk and Dawn

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PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

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Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin

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New selective ligands of human cloned melatonin MT1 and MT2 receptors

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Targeted Disruption of the Mouse Mel1b Melatonin Receptor

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Crystal Structure of Quinone Reductase 2 in Complex with Resveratrol ,

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Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina.

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Activation of human monocytes by the pineal hormone melatonin.

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Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease

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Preferential Formation of MT1/MT2 Melatonin Receptor Heterodimers with Distinct Ligand Interaction Properties Compared with MT2 Homodimers

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Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease

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Dynamic Complexes of β2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin

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Melatonin Receptor Signaling: Finding the Path Through the Dark

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Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A

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Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors

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Filamin-A Binds to the Carboxyl-terminal Tail of the Calcium-sensing Receptor, an Interaction That Participates in CaR-mediated Activation of Mitogen-activated Protein Kinase

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Melatonin Signal Transduction in Hamster Brain: Inhibition of Adenylyl Cyclase by a Pertussis Toxin- Sensitive G Protein*

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Functional Expression of MT2 (Mel1b) Melatonin Receptors in Human PAZ6 Adipocytes

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The Mel1aMelatonin Receptor Is Coupled to Parallel Signal Transduction Pathways1

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Crosstalk between Rap1 and Rac regulates secretion of sAPPα

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Comparative pharmacological studies of melatonin receptors: mt1, mt2 and mt3/qr2. tissue distribution of mt3/qr2 11Abbreviations: MCA-NAT, methoxy-carbonylamino-N-acetyltrypta- mine, 2-[125I]-I-MCA-NAT, 2-[125I]-iodomethoxy-carbonylamino-N-acetyltryptamine; 2-IbMT, 2-iodo-N-butanoyl-5-methoxytryptamine; 4-P-PDOT, 4-phenyl-2-propionamido-tetraline; DH97, N-pentanoyl-2-benzyltryptamine; S20760, 5-methoxy-N-cyclopropanoyl-tryptamine; S24635, N-[2-(5-carbamoylbenzofuran-3-yl)ethyl]-acetamide; S25726, N-methyl-(3-{2-[(cyclopropylcarbonyl)-amino]ethyl}benzo[b]furan-5-yl)carbamate; S26553, N-methyl-{1-[2-(acetylamino)ethyl]-naphthalen-7-yl}carbamate.

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The mammalian pineal gland: known facts, unknown facets

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The Biochemistry of Drug Metabolism – An Introduction

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The melatonin receptor in the human brain: cloning experiments and distribution studies

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Cloning of a melatonin‐related receptor from human pituitary

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Melatonin receptors in rat hippocampus: molecular and functional investigations

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The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system

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p120-catenin: Past and present

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Interaction of the Calcium-sensing Receptor and Filamin, a Potential Scaffolding Protein

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Differential signaling of human Mel1a and Mel1b melatonin receptors through the cyclic guanosine 3′-5′-monophosphate pathway

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Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors

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Melatonin inhibits hippocampal long‐term potentiation

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Increased melatonin 1a‐receptor immunoreactivity in the hippocampus of Alzheimer's disease patients

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NRH:quinone reductase 2: An enzyme of surprises and mysteries

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Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins

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The Biochemistry of Drug Metabolism – An Introduction

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The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei

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Melatonin Plays a Crucial Role in the Regulation of Rhythmic Clock Gene Expression in the Mouse Pars Tuberalis

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Prolonged exposure to melatonin leads to time-dependent sensitization of adenylate cyclase and down-regulates melatonin receptors in pars tuberalis cells from ovine pituitary

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Melatonin desensitizes endogenous MT 2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin

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Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors

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Modulation of Dopamine D2 Receptor Signaling by Actin-Binding Protein (ABP-280)

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2-[125I]Iodomelatonin Binding Sites in Hamster Brain Membranes: Pharmacological Characteristics and Regional Distribution*

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Melatonin receptor subtype expression in human cerebellum

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Effect of MT1 melatonin receptor deletion on melatonin‐mediated phase shift of circadian rhythms in the C57BL/6 mouse

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Characterization of the melatoninergic MT3 binding site on the NRH:quinone oxidoreductase 2 enzyme

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Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating

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Do orphan G‐protein‐coupled receptors have ligand‐independent functions?

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An Association between Idiopathic Parkinson's Disease and Polymorphisms of Phase II Detoxification Enzymes: Glutathione S-Transferase M1 and Quinone Oxidoreductase 1 and 2

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Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice

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Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

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Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease

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Distribution of Melatonin MT1 Receptor Immunoreactivity in Human Retina

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Binding of Filamin to the C-terminal Tail of the Calcitonin Receptor Controls Recycling

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Tyrosine Phosphoproteomics of Fibroblast Growth Factor Signaling

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Melatonin activates an outward current and inhibits Ih in rat suprachiasmatic nucleus neurons

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Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse

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Contrary to other non-photic cues, acute melatonin injection does not induce immediate changes of clock gene mrna expression in the rat suprachiasmatic nuclei

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Cerebrovascular melatonin MT1-receptor alterations in patients with Alzheimer's disease

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G Protein-coupled Receptor Kinase Regulates Dopamine D3 Receptor Signaling by Modulating the Stability of a Receptor-Filamin-β-Arrestin Complex

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Purification and Identification of G Protein-coupled Receptor Protein Complexes under Native Conditions

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Melatonin directly constricts rat cerebral arteries through modulation of potassium channels

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Studies of the renal action of melatonin: evidence that the effects are mediated by 37 kDa receptors of the Meli a subtype localized primarily to the basolateral membrane of the proximal tubule

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Post-translational Modification of Bid Has Differential Effects on Its Susceptibility to Cleavage by Caspase 8 or Caspase 3

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Differential Expression of High-Affinity Melatonin Receptors (MT1) in Normal and Malignant Human Breast Tissue

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Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3

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Melatonin Regulates the Phosphorylation of CREB in Ovine Pars Tuberalis*

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Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor

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MT1 melatonin receptor mRNA expression exhibits a circadian variation in the rat suprachiasmatic nuclei

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Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells.

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The PDZ Protein Mupp1 Promotes Gi Coupling and Signaling of the Mt1 Melatonin Receptor

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Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3′,5′-Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor*

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The MT2 Melatonin Receptor Subtype is Present in Human Retina and Decreases in Alzheimers Disease

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Constitutive dimerization of human serotonin 5‐HT4 receptors in living cells

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Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3

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Melatonin binding sites are functionally coupled to phosphoinositide hydrolysis in Syrian hamster RPMI 1846 melanoma cells

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No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration

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Melatonin limits transcriptional impact of phosphoCREB in the mouse SCN via the Mel1a receptor

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Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors

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Glutamate-induced δ-catenin redistribution and dissociation from postsynaptic receptor complexes

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Are G Protein‐Coupled Receptor Heterodimers of Physiological Relevance?—Focus on Melatonin Receptors

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Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland

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Melatonin Regulates the mRNA Expression of the mt1 Melatonin Receptor in the Rat Pars tuberalis

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Phosphorylation of CREB in Ovine Pars Tuberalis is Regulated both by cyclic AMP‐Dependent and cyclic AMP‐Independent Mechanisms

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Protein Phosphatase 4 Interacts with and Down-regulates Insulin Receptor Substrate 4 following Tumor Necrosis Factor-α Stimulation

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Effects of a novel melatonin analog on circadian rhythms of body temperature and activity in young, middle-aged, and old rats

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Polymorphism and signalling of melatonin receptors

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G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Gαi regulated pathway

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A Generic Approach for the Purification of Signaling Complexes That Specifically Interact with the Carboxyl-terminal Domain of G Protein-coupled Receptors

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Modulation of melatonin receptors and G‐protein function by microtubules

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Physiological Exposure to Melatonin Supersensitizes the Cyclic Adenosine 3',5'-Monophosphate-Dependent Signal Transduction Cascade in Chinese Hamster Ovary Cells Expressing the Human mt1 Melatonin Receptor

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Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopes

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Alternative drug discovery approaches for orphan GPCRs

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Regulation of Melatonin 1a Receptor Signaling and Trafficking by Asparagine-124

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Novel Interaction between the M4 Muscarinic Acetylcholine Receptor and Elongation Factor 1A2

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Untitled work

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Melatonin signaling and cell protection function

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Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

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Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders

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Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

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Protection against cognitive deficits and markers of neurodegeneration by long‐term oral administration of melatonin in a transgenic model of Alzheimer disease

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Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

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Melatonin in macrophage biology: Current understanding and future perspectives

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Beneficial effects of melatonin on bovine oocytes maturation: a mechanistic approach

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Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells

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Heteromeric MT 1 /MT 2 Melatonin Receptors Modulate Photoreceptor Function

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Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression

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New evidence for a role of melatonin in glucose regulation

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Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2C Receptor Heteromers

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Melatonin and IP3-induced Ca2+ Release from Intracellular Stores in the Malaria Parasite Plasmodium falciparum within Infected Red Blood Cells

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Fundamental Issues of Melatonin-Mediated Stress Signaling in Plants

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Quinone reductase 2 as a promising target of melatonin therapeutic actions

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Therapeutic potential of melatonin in traumatic central nervous system injury

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MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations

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Identification of Pathway-Biased and Deleterious Melatonin Receptor Mutants in Autism Spectrum Disorders and in the General Population

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Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease

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Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization

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Melatonin for the treatment of sepsis: the scientific rationale

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Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels

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Use of Melatonin in Cancer Treatment: Where Are We?

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Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit

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Anti-Inflammatory Effects of Melatonin in Obesity and Hypertension

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SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin

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Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

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A new perspective in Oral health: Potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity

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Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence

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Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

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Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?

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Enhancement of high glucose‐induced PINK1 expression by melatonin stimulates neuronal cell survival: Involvement of MT 2 /Akt/NF‐κB pathway

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Melatonin MT1 and MT2 receptors display different molecular pharmacologies only in the G ‐protein coupled state

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Expression of melatonin receptor MT 1 in cells of human invasive ductal breast carcinoma

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Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling

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Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment

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Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders: The melatonin pathway in ADHD

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Neuromodulatory role of melatonin in retinal information processing

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Proliferative effects of melatonin on S chwann cells: implication for nerve regeneration following peripheral nerve injury

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Melatonin and Its Metabolites Can Serve as Agonists on the Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Gamma

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The end of a myth: cloning and characterization of the ovine melatonin MT2 receptor

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The role of melatonin in acute myocardial infarction

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Identification and immunolocalisation of melatonin MT1 and MT2 receptors in Rasa Aragonesa ram spermatozoa

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Type 2 diabetes–associated variants of the MT ₂ melatonin receptor affect distinct modes of signaling

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Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation

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Minireview: Toward the Establishment of a Link between Melatonin and Glucose Homeostasis: Association of Melatonin MT2Receptor Variants with Type 2 Diabetes

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Design and validation of the first cell‐impermeant melatonin receptor agonist

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Structural insights into melatonin receptors

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Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway

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Research progress on the role of melatonin and its receptors in animal reproduction: A comprehensive review

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Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways

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Melatonin–Microbiome Two-Sided Interaction in Dysbiosis-Associated Conditions

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Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression

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Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR‐204‐5p/DPP4 signaling in valvular interstitial cells

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Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A/cAMP-response element binding protein signaling via a Gαs-mediated mechanism

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Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse

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Protein interactome mining defines melatonin MT 1 receptors as integral component of presynaptic protein complexes of neurons

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Protective Effect of Melatonin on Acute Pancreatitis

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Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins

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Anti‐inflammatory effects of melatonin in multiple sclerosis

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Melatonin MT1 and MT2 Receptors in the Ram Reproductive Tract

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Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells

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Exogenous melatonin abolishes mechanical allodynia but not thermal hyperalgesia in neuropathic pain. The role of the opioid system and benzodiazepine-gabaergic mechanism.

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Antioxidant Effect of Melatonin on the Functional Activity of Colostral Phagocytes in Diabetic Women

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Melatonin in Sperm Biology: Breaking Paradigms

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Melatonin receptors as therapeutic targets in the suprachiasmatic nucleus

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Melatonin inhibits insulin secretion in rat insulinoma β-cells (INS-1) heterologously expressing the human melatonin receptor isoform MT2

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Melatonin Receptor Type 1 Signals to Extracellular Signal-Regulated Kinase 1 and 2 via Giand GsDually Coupled Pathways in HEK-293 Cells

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MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

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Melatonin and cancer suppression: insights into its effects on DNA methylation

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Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors

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Modeling the Heterodimer Interfaces of Melatonin Receptors

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Melatonin Receptor Signaling: Impact of Receptor Oligomerization on Receptor Function

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The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization

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Melatonin receptor structure and signaling

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Melatonin: Signaling mechanisms of a pleiotropic agent

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