Cited by 137Circadian rhythm and melatoninPancreatic function and diabetesDiabetes Treatment and Management

New evidence for a role of melatonin in glucose regulation

Peschke, Elmar, Mühlbauer, Eckhard·2010·Best Practice & Research Clinical Endocrinology & Metabolism

Abstract

Glucose triggers insulin secretion of the pancreatic β-cells. The pineal hormone melatonin interferes in this process by inhibiting secretion and transmitting circadian timing information to the islets. Circadian insulin secretion is adapted to day/night changes through melatonin-dependent synchronization. In rats and mice, melatonin levels are high during the dark period, which is their active feeding period, while, in humans, melatonin levels are high during the overnight fasting and sleeping period. This implies a different read-out of melatonin signaling in day-active species, including man. Dysregulation of circadian secretion may be a key to the increase of type 2 diabetes (T2D). This review discusses the impact of melatonin on insulin secretion transmitted through both the pertussis-toxin-sensitive membrane receptors MT1 (MTNR1a) and MT2 (MTNR1b) and the second messengers cAMP, cGMP and IP3. This is an important topic since, in several genetic association studies, single nucleotide polymorphisms of the human MT2-receptor have been described as being causally linked with an elevated risk of developing T2D. This article summarizes interrelationships between melatonin and insulin in type 1 diabetic (T1D) and type 2 diabetic (T2D) rats and humans.

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Crossref · 10.1016/j.beem.2010.09.001

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Authors
Peschke, E., & Mühlbauer, E.
Affiliations
  • Martin Luther University Halle-Wittenberg (DE)
  • Saxon Academy of Sciences and Humanities in Leipzig (DE)
Venue
Best Practice & Research Clinical Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2010-10
Volume
24
Issue
5
Pages
829-841
ISSN
1521-690X (ISSN-L)
OpenAlex
W2096399658
Cited by
137
References
70
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 13
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Locations
  • Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
melatonin, glucose regulation, insulin secretion, pancreatic beta cells, circadian rhythm, type 2 diabetes, type 1 diabetes, MT1 receptor, MT2 receptor, cAMP signaling, cGMP signaling, IP3 signaling, single nucleotide polymorphisms, circadian misalignment
MeSH terms
Animals, Glucose, Humans, Male, Melatonin, Models, Biological, Signal Transduction, Receptors, Melatonin, Mice, Rats

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