Cited by 797TGF-β signaling in diseasesDevelopmental Biology and Gene RegulationSignaling Pathways in Disease

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Specificity, versatility, and control of TGF-β family signaling

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Derynck, Rik, Budi, Erine H.·2019·Science Signaling

DOI 10.1126/scisignal.aav5183PMC PMC6800142

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Abstract

Molecular function and pathway cross-talk in TGF-β signaling reveal its complexity and open questions.

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Background
SMAD1/5-mediated recruitment of the histone demethylase KDM1A controls cell fate programs in embryonic stem cells
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“The Notch receptors represent another type of transmembrane receptors, in which the intracellular domains act as transcription factors after proteolytic cleavage upon stimulatory ligand binding [89].”
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“This finding is supported by the findings of the in vitro and in vivo studies in the present study, in which both BDNF and 7,8-DHF increased the expression of Smad7, a well-known negative regulator of the TGF-β /Smad2/3 pathway (Derynck and Budi, 2019; Yan et al., 2016; Gao et al., 2022).”
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“TGF-β stored in ECM exists mainly in latent complex form, with its activation depending primarily on protease cleavage or integrin-mediated mechanical signals [42, 43].”
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Weak response of bovine hepcidin induction to iron through decreased expression of Smad4
Sadakane, H., Matsumura, M., Murakami, M., Itoyama, E., Shimokawa, F., Sakota, S., Yoshioka, H., Kawabata, H., Matsui, T., & Funaba, M. (2023) · The FASEB Journal · doi:10.1096/fj.202301186rr · Cited by 2
“14 The decreased expression of bovine Smad4 may suppress not only hepcidin transcription but also the canonical BMP pathway.”
Background
Novel Indolyl-Benzimidazole Compounds Promote in vitro Wound Healing and Osteogenic Differentiation of Pluripotent Cells
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“The activation of particular intracellular signaling pathways by the SY-LB compounds to increase cell viability and the rate of wound healing raises an enduring problem in the BMP/BMP receptor field of how the choice of down-stream pathway is regulated [9,15,19,68–70].”
Background
Immunological Aspects of the Pathogenesis of Cicatricial Tracheal Stenosis
Владимирова, Е. С., Nikulina, V. P., Godkov, M. A., & Kasholkina, E. A. (2023) · Russian Sklifosovsky Journal Emergency Medical Care · doi:10.23934/2223-9022-2023-12-3-428-434 · Cited by 2
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“In the present study, BMP7, belonging to the TGF-β superfamily and signal via SMAD1/5/8 [48, 49], is a direct down-stream target of miR-3074.”
Metabolic reprogramming of corn oligopeptide in regulating sodium nitrite-induced canine hepatocyte injury via TGF/NF-κB signaling pathways and aminoacyl-tRNA biosynthesis
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Is TGF-β Associated with Cytokines and Other Biochemical or Clinical Risk Parameters in Early-Onset CAD Patients?
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“It mediates signaling functions, particularly involved in tissue-specific control of cell proliferation, differentiation, and cell and tissue-specific motility [1].”
Advanced cancer therapy: unlocking the potential of small molecule inhibitors
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The multifunctional adaptor protein HIP-55 couples Smad7 to accelerate TGF-β type I receptor degradation
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Retracted
Controlling Smad4 signaling with a Wip
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Non-Smad, BMP-dependent signaling protects against the effects of acute ethanol toxicity
Habeeb, N., Najafi, S., & Perron, J. C. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.10.009 · Cited by 2
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Contreras, O., Soliman, H., Théret, M., Rossi, F. M. V., & Brandan, E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.05.895334 · Cited by 3
TGF-β Pathway
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The Therapeutic Effects of Long-term Photobiomodulation on Aging in MicePreprint
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“Considering the critical role TGF‐β in cellular degeneration, fibrosis, inflammation, regenerative capacity and metabolic functions in humans and mouse alike [34, 35], it is clear that TGF-β1 signaling is part of the mechanistic pathways of PBM.”
Background
Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosisPreprint
Monsivais, D., Liao, Z., Tang, S., Jiang, P., Geng, T., Cope, D. I., Dunn, T. N., Guner, J. Z., Radilla, L. A., & Guan, X. (2023) · Research Square · doi:10.21203/rs.3.rs-3471243/v1 · Cited by 2
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“First, although gamma irradiation did not alter the concentration of TGF-β 1, its potential impact on protein conformation or bioactivity requires further verification through functional assays, such as Smad phosphorylation or downstream gene expression analysis [22,23].”
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“Excessive TGF-β activation is known to contribute to fibrosis in organs such as the liver, lungs, and kidneys [29].”
Rationally Designed Dual Kinase Inhibitors for Management of Obstructive Sleep Apnea—A Computational Study
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RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF ‐β signaling
Rodrigues‐Junior, D. M., Doumani, M. A., Fu, H., van den Bor, J., Idevall‐Hagren, O., & Moustakas, A. (2026) · FEBS Journal · doi:10.1111/febs.70520 · Cited by 1
Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators
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Recent advances in TGF-β signaling: insights into regulation, pathophysiological function, and clinical translation
Yan, X., Zhang, J., Heldin, C., Feng, X.-H., & Chen, Y. (2026) · Cell Regeneration · doi:10.1186/s13619-026-00286-w · Cited by 2
“…factors (GDFs), and the bone morphogenetic protein (BMP) subfamily that includes eleven BMPs, four GDFs, and the anti-Muellerian hormone (AMH) (for reviews, see Derynck and Budi 2019; Hata and Chen 2016; Jia and Meng 2021; Massagué and Sheppard 2023; Morikawa et al. 2016; Yu and Feng 2019).”
Dysregulated transcription in core- and pol-specific CD8 T cells can be targeted by HDAC inhibition to improve T-cell function in chronic hepatitis B
Berti, C. C., Montali, I., Doselli, S., Farina, B., Schivazappa, S., Vecchi, A. L., Rossi, M., Reverberi, V., Montali, A., Sambarino, D., et al. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2026.05.020 · Cited by 1
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Collagen remodeling in breast cancer progression: from molecular mechanisms to diagnostic and therapeutic opportunities
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Overview of biophysical approaches to study osteogenic proteins in lipidic interfaces
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A potential model of systemic sclerosis with pulmonary hypertension induced by monocrotaline plus bleomycin
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“Once activated, the interaction of the Smad2 and Smad3 transcription factors with the Smad4 transcription factor is triggered via phosphorylation, where together they translocate to the nucleus to induce gene transcription (30).”
Background
Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells
Yamamoto, T., Diao, Z., Murakami, M., Shimokawa, F., Matsui, T., & Funaba, M. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155936 · Cited by 1
The Traditional Chinese Medicine Gedan Jiangya Decoction Alleviates Left Ventricular Hypertrophy via Suppressing the Ras/ERK1/2 Signaling Pathway
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Acute Amelioration of Inflammatory Activity Caused by Endothelin-2 Deficiency during Acute Lung Injury.
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“Additionally, transcriptional modulation of proteins from the same family is common [27], possibly including the endothelin peptide family.”
Background

Authors: Derynck, R., & Budi, E. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Derynck, Rik
ORCID: Derynck, Rik
Budi, Erine H.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-02-26
Volume: 12
Issue: 570
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aav5183
PMC: PMC6800142
OpenAlex: W2917714624
Cited by: 785
References: 347
Citations by year: 2026: 83 · 2025: 85 · 2024: 129 · 2023: 118 · 2022: 102 · 2021: 152 · 2020: 77 · 2019: 35
FWCI: 8.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (RO1-CA63101, RO1-CA136690)
JDRF (3-APF-2017-392-A-N)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Smad proteins, TGF-beta receptor, dual-specificity kinase, signaling crosstalk, non-Smad signaling, cancer, fibrosis, developmental anomalies
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Ligands, Neoplasms, Protein Binding, Signal Transduction, Transforming Growth Factor beta, Receptors, Transforming Growth Factor beta

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