Cited by 797TGF-β signaling in diseasesDevelopmental Biology and Gene RegulationSignaling Pathways in Disease

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Specificity, versatility, and control of TGF-β family signaling

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Derynck, Rik, Budi, Erine H.·2019·Science Signaling

DOI 10.1126/scisignal.aav5183PMC PMC6800142

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Abstract

Molecular function and pathway cross-talk in TGF-β signaling reveal its complexity and open questions.

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The protein kinase complement of the human genome
Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145 · cited 1×
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Background
Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
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Ubiquitin modifications
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Background
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
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R. Derynck K. Miyazono The Biology of the TGF-β Family (Cold Spring Harbor Laboratory Press 2017) pp. 1164.

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Additional file 21 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992925
Additional file 1 of FOXO1 mitigates the SMAD3/FOXL2C134W transcriptomic effect in a model of human adult granulosa cell tumor
Secchi, C., Benaglio, P., Mulas, F., Belli, M., Stupack, D., & Shimasaki, S. (2021) · Figshare · doi:10.6084/m9.figshare.14131182
Additional file 20 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992919
Additional file 16 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992904
Additional file 1 of Large-scale phosphoproteomics reveals activation of the MAPK/GADD45β/P38 axis and cell cycle inhibition in response to BMP9 and BMP10 stimulation in endothelial cells
Tarrass, M. A., Belmudes, L., Koça, D., Azemard, V., Liu, H., Tabosh, T. A., Ciais, D., Desroches‐Castan, A., Battail, C., Couté, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25341247
Additional file 6 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14993058
Additional file 8 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14993064
Additional file 4 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14993052
Additional file 18 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992910
Additional file 1 of Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model
Wu, X., Shen, Q., Zhang, Z., Zhang, D., Gu, Y., & Xing, D. (2021) · Figshare · doi:10.6084/m9.figshare.14773927
Additional file 5 of MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030993
Additional file 3 of CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro
Alishah, K., Birtel, M., Masoumi, E., Jafarzadeh, L., Mirzaee, H. R., Hadjati, J., Voss, R.-H., Diken, M., & Asad, S. (2021) · Figshare · doi:10.6084/m9.figshare.17087824
Additional file 7 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14993061
Additional file 8 of Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes
Pucci, M., Moschetti, M., Urzì, O., Loria, M., Conigliaro, A., Bella, M. A. D., Crescitelli, R., Bagge, R. O., Gallo, A., Santos, M. F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.26583204
Additional file 7 of Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes
Pucci, M., Moschetti, M., Urzì, O., Loria, M., Conigliaro, A., Bella, M. A. D., Crescitelli, R., Bagge, R. O., Gallo, A., Santos, M. F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.26583201
Additional file 3 of Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes
Pucci, M., Moschetti, M., Urzì, O., Loria, M., Conigliaro, A., Bella, M. A. D., Crescitelli, R., Bagge, R. O., Gallo, A., Santos, M. F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.26583192
Additional file 15 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992901
Additional file 9 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14993067
Additional file 2 of MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030984
Additional file 2 of CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro
Alishah, K., Birtel, M., Masoumi, E., Jafarzadeh, L., Mirzaee, H. R., Hadjati, J., Voss, R.-H., Diken, M., & Asad, S. (2021) · Figshare · doi:10.6084/m9.figshare.17087821
Additional file 11 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992886
Additional file 5 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14993055
Additional file 1 of Reduced frequencies of Foxp3+GARP+ regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype
Hou, J., Wang, X., Su, C., Ma, W., Zheng, X., Ge, X., & 段相国 (2022) · Figshare · doi:10.6084/m9.figshare.20222564
Additional file 12 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992889
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Authors: Derynck, R., & Budi, E. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Derynck, Rik
ORCID: Derynck, Rik
Budi, Erine H.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-02-26
Volume: 12
Issue: 570
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aav5183
PMC: PMC6800142
OpenAlex: W2917714624
Cited by: 785
References: 347
Citations by year: 2026: 83 · 2025: 85 · 2024: 129 · 2023: 118 · 2022: 102 · 2021: 152 · 2020: 77 · 2019: 35
FWCI: 8.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (RO1-CA63101, RO1-CA136690)
JDRF (3-APF-2017-392-A-N)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Smad proteins, TGF-beta receptor, dual-specificity kinase, signaling crosstalk, non-Smad signaling, cancer, fibrosis, developmental anomalies
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Ligands, Neoplasms, Protein Binding, Signal Transduction, Transforming Growth Factor beta, Receptors, Transforming Growth Factor beta

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