Cited by 797TGF-β signaling in diseasesDevelopmental Biology and Gene RegulationSignaling Pathways in Disease

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Specificity, versatility, and control of TGF-β family signaling

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Derynck, Rik, Budi, Erine H.·2019·Science Signaling

DOI 10.1126/scisignal.aav5183PMC PMC6800142

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Molecular function and pathway cross-talk in TGF-β signaling reveal its complexity and open questions.

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Background
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R. Derynck K. Miyazono The Biology of the TGF-β Family (Cold Spring Harbor Laboratory Press 2017) pp. 1164.

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Author Response: Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy
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Additional file 3 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700654
Additional file 7 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700666
Additional file 5 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700660
Additional file 1 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700648
Additional file 10 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700675
Additional file 2 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700651
Additional file 9 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700672
Additional file 4 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700657
Additional file 8 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700669
Additional file 6 of TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells
Ping, Q., Wang, C., Cheng, X., Zhong, Y., Yan, R., Yang, M., Shi, Y., Li, X., Li, X., Huang, W., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23700663
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“These findings suggest that Smad3 may interact with and regulate other TGFβ1 signaling mediators that bind to this region of the promoter (Derynck and Budi, 2019).”
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Additional file 10 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
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Additional file 14 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992895
Additional file 1 of TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts
Zhou, Z., Liang, S., Zhou, Z., Liu, J., Zhang, J., Meng, X., Zou, F., Zhao, H., Yu, C., & Cai, S. (2023) · Figshare · doi:10.6084/m9.figshare.22601419
Additional file 19 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992913
Additional file 13 of Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human
Chijimatsu, R., Miwa, S., Okamura, G., Miyahara, J., Tachibana, N., Ishikura, H., Higuchi, J., Maenohara, Y., Tsuji, S., Sameshima, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14992892
Additional file 1 of MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030981
Additional file 1 of Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
Decaris, M. L., Schaub, J. R., Chen, C., Cha, J., Lee, G. G., Rexhepaj, M., Ho, S. S., Rao, V. R., Marlow, M. M., Kotak, P., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16835291
Self-citation
Additional file 1 of CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro
Alishah, K., Birtel, M., Masoumi, E., Jafarzadeh, L., Mirzaee, H. R., Hadjati, J., Voss, R.-H., Diken, M., & Asad, S. (2021) · Figshare · doi:10.6084/m9.figshare.17087818
Additional file 3 of MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030987
Additional file 4 of MKRN1 promotes colorectal cancer metastasis by activating the TGF-β signalling pathway through SNIP1 protein degradation
Zhang, Y., Li, Q.-S., Liu, H.-L., Tang, H.-T., Yang, H.-L., Wu, D., Huang, Y.-Y., Li, L.-C., Liu, L.-H., & Li, M. (2023) · Figshare · doi:10.6084/m9.figshare.24030990
Additional file 4 of Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes
Pucci, M., Moschetti, M., Urzì, O., Loria, M., Conigliaro, A., Bella, M. A. D., Crescitelli, R., Bagge, R. O., Gallo, A., Santos, M. F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.26583195
Additional file 6 of Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of hepatocytes
Pucci, M., Moschetti, M., Urzì, O., Loria, M., Conigliaro, A., Bella, M. A. D., Crescitelli, R., Bagge, R. O., Gallo, A., Santos, M. F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.26583198

Authors: Derynck, R., & Budi, E. H.
Affiliations: University of California, San Francisco (US)
Corresponding author: Derynck, Rik
ORCID: Derynck, Rik
Budi, Erine H.
Venue: Science Signaling
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2019-02-26
Volume: 12
Issue: 570
ISSN: 1937-9145 (ISSN-L)
1945-0877
DOI: 10.1126/scisignal.aav5183
PMC: PMC6800142
OpenAlex: W2917714624
Cited by: 785
References: 347
Citations by year: 2026: 83 · 2025: 85 · 2024: 129 · 2023: 118 · 2022: 102 · 2021: 152 · 2020: 77 · 2019: 35
FWCI: 8.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Science Signaling (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Cancer Institute (RO1-CA63101, RO1-CA136690)
JDRF (3-APF-2017-392-A-N)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Smad proteins, TGF-beta receptor, dual-specificity kinase, signaling crosstalk, non-Smad signaling, cancer, fibrosis, developmental anomalies
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Ligands, Neoplasms, Protein Binding, Signal Transduction, Transforming Growth Factor beta, Receptors, Transforming Growth Factor beta

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