Cited by 236Sleep and Work-Related FatigueSleep and Wakefulness ResearchCircadian rhythm and melatonin

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Uncovering Residual Effects of Chronic Sleep Loss on Human Performance

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Cohen, Daniel A., Wang, Wei, Wyatt, James K., Kronauer, Richard E., Dijk, Derk-Jan, Czeisler, Charles A., Klerman, Elizabeth B.·2010·Science Translational Medicine

DOI 10.1126/scitranslmed.3000458PMC PMC2892834

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Abstract

Sleep loss leads to profound performance decrements. Yet many individuals believe they adapt to chronic sleep loss or that recovery requires only a single extended sleep episode. To evaluate this, we designed a protocol whereby the durations of sleep and wake episodes were increased to 10 and 32.85 hours, respectively, to yield a reduced sleep-to-wake ratio of 1:3.3. These sleep and wake episodes were distributed across all circadian phases, enabling measurement of the effects of acute and chronic sleep loss at different times of the circadian day and night. Despite recurrent acute and substantial chronic sleep loss, 10-hour sleep opportunities consistently restored vigilance task performance during the first several hours of wakefulness. However, chronic sleep loss markedly increased the rate of deterioration in performance across wakefulness, particularly during the circadian "night." Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences.

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Authors: Cohen, D. A., Wang, W., Wyatt, J. K., Kronauer, R. E., Dijk, D.-J., Czeisler, C. A., & Klerman, E. B.
Affiliations: Brigham and Women's Hospital (US)
Rush University Medical Center (US)
Harvard University (US)
University of Surrey (GB)
Corresponding author: Cohen, Daniel A.
ORCID: Wang, Wei
Wyatt, James K.
Dijk, Derk-Jan
Czeisler, Charles A.
Klerman, Elizabeth B.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2010-01-13
Volume: 2
Issue: 14
Pages: 14ra3-14ra3
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3000458
PMC: PMC2892834
OpenAlex: W2147523200
Cited by: 236
References: 35
Citations by year: 2026: 7 · 2025: 7 · 2024: 8 · 2023: 14 · 2022: 14 · 2021: 16 · 2020: 16 · 2019: 18 · 2018: 13 · 2017: 13 · 2016: 15 · 2015: 18 · 2014: 18 · 2013: 18 · 2012: 21
FWCI: 23.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders: National Institute on Aging (P01AG009975)
National Heart, Lung, and Blood Institute (T32HL007901)
National Center for Research Resources (M01RR002635)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K02HD045459)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: chronic sleep loss, sleep deprivation, sustained attention, cognitive performance, circadian rhythm, extended wakefulness, performance recovery
MeSH terms: Adult, Attention, Circadian Rhythm, Female, Humans, Male, Psychomotor Performance, Reaction Time, Sleep, Wakefulness, Work Schedule Tolerance, Models, Statistical

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Uncovering Residual Effects of Chronic Sleep Loss on Human Performance

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