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Translating Glutamate: From Pathophysiology to Treatment
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On 21 to 22 June 2010, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, discussed the role of glutamate in neuropsychiatric disease at the meeting “Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System.”
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“As in humans, treatment of adult rodents with NMDAR antagonists triggers acute schizophrenia-related behaviours, including deficits in attention and/ or vigilance, learning and memory and sensory gating, broadly mimicking the symptoms of patients with schizophrenia 10,15,23,24 .”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [15]
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“Subsequent behavioral, neurophysiological and functional imaging studies have supported the NMDAR hypofunction hypothesis of schizophrenia, showing that indicators of sensory dysfunction in patients with schizophrenia -such as mismatch negativity (MMN) and changes in auditory and visual event-related potentials -can be mimicked by treating otherwise healthy individuals with NMDAR antagonists 12,15”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [15]
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Metadata
- Authors
- Javitt, D. C., Schoepp, D., Kalivas, P. W., Volkow, N. D., Zarate, C., Merchant, K., Bear, M. F., Umbricht, D., Hajos, M., Potter, W. Z., & Lee, C.-M.
- Affiliations
- Columbia University (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Medical University of South Carolina (US)
- National Institute on Drug Abuse (US)
- National Institutes of Health (US)
- Eli Lilly (United States) (US)
- Massachusetts Institute of Technology (US)
- F. Hoffmann-La Roche AG (CH)
- Neuroscience Department, CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA.
- Foundation for the National Institutes of Health (US)
- AstraZeneca (Sweden) (SE)
- Corresponding author
- Javitt, Daniel C.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2011-09-28
- Volume
- 3
- Issue
- 102
- Pages
- 102mr2-102mr2
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3273336
- OpenAlex
- W1559706924
- Cited by
- 168
- References
- 150
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 14 · 2018: 10 · 2017: 10 · 2016: 5 · 2015: 19 · 2014: 19 · 2013: 19 · 2012: 22
- Type
- conference abstract
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R37MH049334, R37MH49334, P50MH086385, ZIAMH002857)
- National Institute on Drug Abuse (R01DA03383, R01DA003383)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD046943)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- glutamate, glutamatergic neurotransmission, neuropsychiatric disorders, schizophrenia, drug addiction, autism spectrum disorder, depression, biomarkers, translational model, drug development, target engagement
- MeSH terms
- Animals, Clinical Trials as Topic, Congresses as Topic, Humans, Nervous System Diseases, Neurotransmitter Agents, Glutamic Acid, Mice, Translational Research, Biomedical
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