Cited by 133Autoimmune Neurological Disorders and TreatmentsSystemic Lupus Erythematosus ResearchPeripheral Neuropathies and Disorders

The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease

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Kayser, M. S., Dalmau, J.·2011·Journal of Neuropsychiatry

Abstract

Abnormal autoimmune activity has been implicated in a number of neuropsychiatric disorders. In this review, the authors discuss a newly recognized class of synaptic autoimmune encephalitides as well as behavioral and cognitive manifestations of systemic autoimmune diseases.

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Registry

Crossref · 10.1176/appi.neuropsych.23.1.90

Cites

73 of 73 references verified0 citation errors · 0 not checkable

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  • Rapidly progressive alterations of memory, behavior, cognition, and psychosis previously thought to be idiopathic or viral-induced are now known to be autoimmune.

    “Rapidly progressive alterations of memory, behavior, cognition, and psychosis previously thought to be idiopathic or viral-induced are now known to be autoimmune.20-23”

    From Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study (2013) · cites this paper as [21]

    The “Autoimmune Synaptic Encephalitis” section says limbic encephalitides once thought viral or paraneoplastic commonly have an autoimmune cause and can develop over days to weeks with memory and psychiatric symptoms. The claim overgeneralizes this finding: the paper does not say that rapidly progressive changes of these kinds are all now known to be autoimmune, and it describes some cases as idiopathic autoimmune processes rather than formerly thought idiopathic. (LLM, conf=0.84)

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Authors
Kayser, M. S., & Dalmau, J.
Affiliations
University of Pennsylvania (US)
Venue
Journal of Neuropsychiatry
Published
2011-02-01
Volume
23
Issue
1
Pages
90-97
ISSN
0895-0172 (ISSN-L)
OpenAlex
W2122331073
Cited by
133
References
74
Citations by year
2026: 6 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 5 · 2014: 9 · 2013: 11 · 2012: 9
FWCI
6.50
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (CA89054, R01CA089054, R56CA089054)
  • National Institute of Neurological Disorders and Stroke (NS068204, RC1NS068204, R01NS077851)
Topics
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
autoimmune disease, neuropsychiatric disorders, autoimmune encephalitis, behavioral manifestations, cognitive impairment, systemic autoimmune diseases
MeSH terms
Animals, Autoimmune Diseases, Mental Disorders, Brain, Encephalitis, Humans, Lupus Erythematosus, Systemic, Receptors, N-Methyl-D-Aspartate, Receptors, AMPA

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