The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease
Open accessAbstract
Abnormal autoimmune activity has been implicated in a number of neuropsychiatric disorders. In this review, the authors discuss a newly recognized class of synaptic autoimmune encephalitides as well as behavioral and cognitive manifestations of systemic autoimmune diseases.
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Rapidly progressive alterations of memory, behavior, cognition, and psychosis previously thought to be idiopathic or viral-induced are now known to be autoimmune.
“Rapidly progressive alterations of memory, behavior, cognition, and psychosis previously thought to be idiopathic or viral-induced are now known to be autoimmune.20-23”
From Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study (2013) · cites this paper as [21]
The “Autoimmune Synaptic Encephalitis” section says limbic encephalitides once thought viral or paraneoplastic commonly have an autoimmune cause and can develop over days to weeks with memory and psychiatric symptoms. The claim overgeneralizes this finding: the paper does not say that rapidly progressive changes of these kinds are all now known to be autoimmune, and it describes some cases as idiopathic autoimmune processes rather than formerly thought idiopathic. (LLM, conf=0.84)
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- Authors
- Kayser, M. S., & Dalmau, J.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Journal of Neuropsychiatry
- Published
- 2011-02-01
- Volume
- 23
- Issue
- 1
- Pages
- 90-97
- ISSN
- 0895-0172 (ISSN-L)
- PMC
- PMC3086677
- OpenAlex
- W2122331073
- Cited by
- 133
- References
- 74
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 13 · 2015: 5 · 2014: 9 · 2013: 11 · 2012: 9
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA89054, R01CA089054, R56CA089054)
- National Institute of Neurological Disorders and Stroke (NS068204, RC1NS068204, R01NS077851)
- Topics
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- autoimmune disease, neuropsychiatric disorders, autoimmune encephalitis, behavioral manifestations, cognitive impairment, systemic autoimmune diseases
- MeSH terms
- Animals, Autoimmune Diseases, Mental Disorders, Brain, Encephalitis, Humans, Lupus Erythematosus, Systemic, Receptors, N-Methyl-D-Aspartate, Receptors, AMPA
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