Dynamic Microenvironments: The Fourth Dimension
Abstract
Four-dimensional cell matrices that recapitulate tissue and organ function will aid in the translation of cell-based therapies.
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Synthetic hydrogels can be functionalized with biologically active moieties that permit the growth and spread of cells; concentration and spacing of these cues can be changed independently.
“Synthetic hydrogels can be functionalized with biologically active moieties that permit the growth and spread of cells146–151; concentration and spacing of these cues can be changed independently152–155.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [149]
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- Authors
- Tibbitt, M. W., & Anseth, K. S.
- Affiliations
- University of Colorado Boulder (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Anseth, Kristi S.
- Venue
- Science Translational Medicine
- Published
- 2012-11-14
- Volume
- 4
- Issue
- 160
- Pages
- 160ps24-160ps24
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2140880846
- Cited by
- 169
- References
- 22
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 16 · 2020: 10 · 2019: 19 · 2018: 18 · 2017: 13 · 2016: 12 · 2015: 14 · 2014: 27 · 2013: 11
- FWCI
- 9.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Dental and Craniofacial Research (R01DE016523)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- cell microenvironment, extracellular matrix, 3D tissue engineering, in vitro tissue models, cell behavior, cell therapy, disease modeling
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Materials Testing, Wound Healing, Drug Design, Developmental Biology, Disease Progression, Cell Culture Techniques, Tissue Engineering
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