The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy
Abstract
Pharmacological use of ascorbate (vitamin C) enhanced chemosensitivity of ovarian cancer in preclinical models and reduced chemotherapy-associated toxicity in patients.
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“A significant number of human studies consistently show that ascorbate treatment improved quality of life for patients with cancer, and in combination therapy, ascorbate protected normal tissues from toxicity caused by chemotherapy114.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [114]
In the citing paper
“A significant number of human studies consistently show that ascorbate treatment improved quality of life for patients with cancer, and in combination therapy, ascorbate protected normal tissues from toxicity caused by chemotherapy114.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [114]
In the citing paper
“This paper shows in its preclinical and clinical studies that high-dose vitamin C can potentially increase the efficacy and reduce the toxicities of certain conventional chemotherapies when used in combination to treat patients with ovarian cancer.”
From Targeting cancer vulnerabilities with high-dose vitamin C (2019) · cites this paper as [114]
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Metadata
- Authors
- Ma, Y., Chapman, J., Levine, M., Polireddy, K., Drisko, J., & Chen, Q.
- Affiliations
- University of Kansas Medical Center (US)
- National Institutes of Health (US)
- Corresponding author
- Drisko, Jeanne
- Chen, Qi
- Venue
- Science Translational Medicine
- Published
- 2014-02-05
- Volume
- 6
- Issue
- 222
- Pages
- 222ra18-222ra18
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2139847043
- Cited by
- 501
- References
- 57
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 44 · 2023: 55 · 2022: 50 · 2021: 51 · 2020: 42 · 2019: 44 · 2018: 53 · 2017: 38 · 2016: 28 · 2015: 23 · 2014: 21
- FWCI
- 34.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- vitamin C, ovarian cancer, chemosensitization, carboplatin, paclitaxel, chemotherapy toxicity, pro-oxidant activity, hydrogen peroxide, DNA damage, ATP depletion, mTOR inhibition, combination therapy, cancer cell death
- MeSH terms
- Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Ascorbic Acid, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Synergism, Female, Humans, Infusions, Parenteral, Ovarian Neoplasms, Carboplatin, Cell Death, Paclitaxel, Xenograft Model Antitumor Assays, Mice
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