Cited by 501Vitamin C and Antioxidants ResearchOvarian cancer diagnosis and treatmentCancer, Hypoxia, and Metabolism

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High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

Ma, Yan, Chapman, Julia, Levine, Mark, Polireddy, Kishore, Drisko, Jeanne, Chen, Qi·2014·Science Translational Medicine

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Abstract

Pharmacological use of ascorbate (vitamin C) enhanced chemosensitivity of ovarian cancer in preclinical models and reduced chemotherapy-associated toxicity in patients.

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Crossref · 10.1126/scitranslmed.3007154

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Authors: Ma, Y., Chapman, J., Levine, M., Polireddy, K., Drisko, J., & Chen, Q.
Affiliations: University of Kansas Medical Center (US)
National Institutes of Health (US)
Corresponding author: Drisko, Jeanne
Chen, Qi
ORCID: Ma, Yan
Chapman, Julia
Levine, Mark
Drisko, Jeanne
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-02-05
Volume: 6
Issue: 222
Pages: 222ra18-222ra18
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3007154
OpenAlex: W2139847043
Cited by: 501
References: 57
Citations by year: 2026: 23 · 2025: 29 · 2024: 44 · 2023: 55 · 2022: 50 · 2021: 51 · 2020: 42 · 2019: 44 · 2018: 53 · 2017: 38 · 2016: 28 · 2015: 23 · 2014: 21
FWCI: 34.15
Type: journal article
Language: en
Open access: closed
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: vitamin C, ovarian cancer, chemosensitization, carboplatin, paclitaxel, chemotherapy toxicity, pro-oxidant activity, hydrogen peroxide, DNA damage, ATP depletion, mTOR inhibition, combination therapy, cancer cell death
MeSH terms: Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Ascorbic Acid, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Synergism, Female, Humans, Infusions, Parenteral, Ovarian Neoplasms, Carboplatin, Cell Death, Paclitaxel, Xenograft Model Antitumor Assays, Mice

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High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy

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