Cited by 381Congenital heart defects researchNeurogenesis and neuroplasticity mechanismsCardiac Fibrosis and Remodeling

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A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

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Tian, Ying, Liu, Ying, Wang, Tao, Zhou, Ning, Kong, Jun, Chen, Li, Snitow, Melinda, Morley, Michael, Li, Deqiang, Petrenko, Nataliya, Zhou, Su, Lu, Minmin, Gao, Erhe, Koch, Walter J., Stewart, Kathleen M., Morrisey, Edward E.·2015·Science Translational Medicine

DOI 10.1126/scitranslmed.3010841PMC PMC6295313

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Abstract

A microRNA-based therapeutic approach could be used to promote cardiac regeneration through the transient activation of cardiomyocyte proliferation.

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Authors: Tian, Y., Liu, Y., Wang, T., Zhou, N., Kong, J., Chen, L., Snitow, M., Morley, M., Li, D., Petrenko, N., Zhou, S., Lu, M., Gao, E., Koch, W. J., Stewart, K. M., & Morrisey, E. E.
Affiliations: University of Pennsylvania (US)
Tang Du Hospital (CN)
Temple University (US)
Corresponding author: Tian, Ying
Morrisey, Edward E.
ORCID: Tian, Ying
Liu, Ying
Wang, Tao
Chen, Li
Snitow, Melinda
Morley, Michael
Li, Deqiang
Zhou, Su
Lu, Minmin
Gao, Erhe
Koch, Walter J.
Morrisey, Edward E.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-03-18
Volume: 7
Issue: 279
Pages: 279ra38-279ra38
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.3010841
PMC: PMC6295313
OpenAlex: W2140775408
Cited by: 381
References: 42
Citations by year: 2026: 10 · 2025: 27 · 2024: 36 · 2023: 36 · 2022: 35 · 2021: 43 · 2020: 45 · 2019: 41 · 2018: 28 · 2017: 40 · 2016: 26 · 2015: 14
FWCI: 15.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01-HL064632, R01-HL087825, U01-HL100405, K99/R00-HL111348)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: cardiomyocyte proliferation, cardiac regeneration, Hippo signaling pathway, myocardial infarction, myocardial fibrosis, cardiomyocyte dedifferentiation, miRNA-based therapy, cardiac repair, cell cycle re-entry, heart development
MeSH terms: Hippo Signaling Pathway, Alleles, Animals, Cell Cycle, Cell Separation, Cells, Cultured, Flow Cytometry, Heart, Humans, Lipids, Male, Myocardial Infarction, Regeneration, Signal Transduction, Lentivirus, Protein Serine-Threonine Kinases, Myocytes, Cardiac, MicroRNAs, Cell Proliferation, Mice, HEK293 Cells

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A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

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