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Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy: Table 1.

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Role and mechanism of ferroptosis in neurological diseases

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Increased Expression of System xc− in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance

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Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

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Involvement of extrasynaptic glutamate in physiological and pathophysiological changes of neuronal excitability

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Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

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Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance

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Repetitive Diffuse Mild Traumatic Brain Injury Causes an Atypical Astrocyte Response and Spontaneous Recurrent Seizures

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Inhibition of xCT suppresses the efficacy of anti-PD-1/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization

Liu, N., Zhang, J., Yin, M., Liu, H., Zhang, X., Li, J., Yan, B., Guo, Y., Zhou, J., Tao, J., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.013 · Cited by 126 · see citing works

Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells

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The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc( — )

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Role of the Microenvironment in Glioma Pathogenesis

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Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model

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Targeting Glutamine Addiction in Gliomas

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Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition

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Glioma-Induced Alterations in Neuronal Activity and Neurovascular Coupling during Disease Progression

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Interactions between Tumor Cells, Neurons, and Microglia in the Glioma Microenvironment

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A synthetic lethal drug combination mimics glucose deprivation–induced cancer cell death in the presence of glucose

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Ferroptosis in life: To be or not to be

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AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro

Lange, F., Weßlau, K., Porath, K., Hörnschemeyer, M. F., Bergner, C., Krause, B. J., Mullins, C. S., Linnebacher, M., Köhling, R., & Kirschstein, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211644 · Cited by 94 · see citing works

Regulated cell death in cancer: from pathogenesis to treatment

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Glutamatergic Mechanisms in Glioblastoma and Tumor-Associated Epilepsy

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Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It

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The cystine‐glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

Ottestad‐Hansen, S., Hu, Q. X., Follin‐Arbelet, V. V., Bentea, E., Sato, H., Massie, A., Zhou, Y., & Danbolt, N. C. (2018) · Glia · doi:10.1002/glia.23294 · Cited by 88 · see citing works

A synthetic lethal drug combination mimics glucose deprivation–induced cancer cell death in the presence of glucose

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Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging

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Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation

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Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment

Wan, S., Zhang, G., Liu, R., Abbas, M. N., & Cui, H. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01108-1 · Cited by 83 · see citing works

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors

Zille, M., Kumar, A., Kundu, N., Bourassa, M. W., Wong, V. S. C., Willis, D. E., Karuppagounder, S. S., & Ratan, R. R. (2019) · eNeuro · doi:10.1523/eneuro.0263-18.2019 · Cited by 84 · see citing works

Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration

Portela, M., Venkataramani, V., Fahey-Lozano, N., Seco, E., Losada‐Pérez, M., Winkler, F., & Casas‐Tintó, S. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000545 · Cited by 76 · see citing works

Macrophage xCT deficiency drives immune activation and boosts responses to immune checkpoint blockade in lung cancer

Tang, B., Wang, Y., Xu, W., Zhu, J., Weng, Q., Chen, W., Fang, S., Yang, Y., Qiu, R., Chen, M., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216021 · Cited by 74 · see citing works

xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction

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HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis

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Astrocytes as a target for therapeutic strategies in epilepsy: current insights

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High expression of cystine–glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma

Sørensen, M. F., Heimisdóttir, S. B., Sørensen, M. D., Mellegaard, C. S., Wohlleben, H., Kristensen, B. W., & Beier, C. P. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2785-9 · Cited by 68 · see citing works

Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications

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Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?

Lefranc, F., Rhun, É. L., Robert Kiss, A., & Weller, M. (2018) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2018.06.017 · Cited by 66 · see citing works

Astrocytes and Epilepsy

Binder, D. K., & Steinhäuser, C. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03236-x · Cited by 65 · see citing works

Regulated Necrotic Cell Death in Alternative Tumor Therapeutic Strategies

Woo, Y., Lee, H.-J., Jung, Y. M., & Jung, Y. (2020) · Cells · doi:10.3390/cells9122709 · Cited by 65 · see citing works

Glioma exosomal microRNA-148a-3p promotes tumor angiogenesis through activating the EGFR/MAPK signaling pathway via inhibiting ERRFI1

Wang, M., Zhao, Y., Yu, Z., Zhang, R.-D., Li, S., Zhang, P., Shan, T.-K., Liu, X., Wang, Z.-M., Zhao, P., et al. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01566-4 · Cited by 63 · see citing works

Hypoxia-Induced Neuronal Activity in Glioma Patients Polarizes Microglia by Potentiating RNA m6A Demethylation

Guo, X., Qiu, W., Li, B., Qi, Y., Wang, S., Zhao, R., Cheng, B., Han, X., Du, H., Pan, Z., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0430 · Cited by 63 · see citing works

Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors (Review)

Tang, X., Chen, W., Liu, H., Liu, N., Chen, D., Tian, D., & Wang, J. (2021) · Oncology Letters · doi:10.3892/ol.2021.13165 · Cited by 60 · see citing works

Seizures in glioma patients: An overview of incidence, etiology, and therapies

Samudra, N. P., Zacharias, T., Plitt, A. R., Lega, B. C., & Pan, E. (2019) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2019.07.026 · Cited by 59 · see citing works

Neuronal Activity Promotes Glioma Progression by Inducing Proneural-to-Mesenchymal Transition in Glioma Stem Cells

Guo, X., Qiu, W., Wang, C., Qi, Y., Li, B., Wang, S., Zhao, R., Cheng, B., Han, X., Du, H., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0609 · Cited by 59 · see citing works

Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-Glutamate (18F-FSPG) for PET/CT Imaging of Intracranial Malignancies

Mittra, E., Koglin, N., Mosci, C., Kumar, M., Höhne, A., Keu, K. V., Iagaru, A. H., Mueller, A., Berndt, M., Bullich, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148628 · Cited by 56 · see citing works

The ubiquitin hydrolase OTUB1 promotes glioma cell stemness via suppressing ferroptosis through stabilizing SLC7A11 protein

Zhao, X., Zhou, M., Yang, Y., & Luo, M. (2021) · Bioengineered · doi:10.1080/21655979.2021.2011633 · Cited by 53 · see citing works

Glial Glutamate Transporter-Mediated Plasticity: System xc-/xCT/SLC7A11 and EAAT1/2 in Brain Diseases

Dahlmanns, M., Dahlmanns, J. K., Savaskan, N. E., Steiner, H. H., & Yakubov, E. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2803057 · Cited by 52 · see citing works

Astrocytes and Epilepsy

Binder, D. K., & Steinhäuser, C. (2016) · Elsevier eBooks · doi:10.1016/c2014-0-03100-0 · Cited by 52 · see citing works

A map of the altered glioma metabolism

Deshmukh, R. S., Allega, M. F., & Tardito, S. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.07.011 · Cited by 52 · see citing works

SLC7A11 promotes the progression of gastric cancer and regulates ferroptosis through PI3K/AKT pathway

Jiang, Y., Cui, J., Cui, M., & Jing, R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154646 · Cited by 48 · see citing works

SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma

Ma, Z., Zhang, H., Lian, M., Yue, C., Dong, G., Jin, Y., Li, R., Wan, H., Wang, R., Wang, Y., et al. (2017) · Oncology Reports · doi:10.3892/or.2017.5976 · Cited by 48 · see citing works

Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes

Campbell, S. C., Muñoz‐Ballester, C., Chaunsali, L., Mills, W. A., Yang, J. H., Sontheimer, H. W., & Robel, S. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104628 · Cited by 49 · see citing works

LncRNA T-UCR Uc.339/miR-339/SLC7A11 Axis Regulates the Metastasis of Ferroptosis-Induced Lung Adenocarcinoma

Zhang, N., Huang, J., Xu, M., & Wang, Y. (2022) · Journal of Cancer · doi:10.7150/jca.65017 · Cited by 47 · see citing works

Does the choice of antiepileptic drug affect survival in glioblastoma patients?

Knudsen-Baas, K. M., Engeland, A., Gilhus, N. E., Storstein, A. M., & Owe, J. F. (2016) · Journal of Neuro-Oncology · doi:10.1007/s11060-016-2191-0 · Cited by 47 · see citing works

Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma

Shen, L., Qian, C., Cao, H., Wang, Z., Luo, T., & Liang, C. (2018) · World Journal of Surgical Oncology · doi:10.1186/s12957-018-1535-y · Cited by 47 · see citing works

Multi‐omics technologies and molecular biomarkers in brain tumor‐related epilepsy

Du, Y., Li, R., Fu, D., Zhang, B., Cui, A., Shao, Y., Lai, Z., Chen, R., Chen, B., Wang, Z., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14717 · Cited by 45 · see citing works

Membrane Transporters for Amino Acids as Players of Cancer Metabolic Rewiring

Scalise, M., Console, L., Rovella, F., Galluccio, M., Pochini, L., & Indiveri, C. (2020) · Cells · doi:10.3390/cells9092028 · Cited by 45 · see citing works

Dysregulation of Ambient Glutamate and Glutamate Receptors in Epilepsy: An Astrocytic Perspective

Alcoreza, O. B., Patel, D. C., Tewari, B. P., & Sontheimer, H. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.652159 · Cited by 44 · see citing works

Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed

Liefferinge, J. V., Bentea, E., Demuyser, T., Albertini, G., Follin-Arbelet, V. V., Holmseth, S., Merckx, E., Sato, H., Aerts, J. L., Smolders, I. J., et al. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23889 · Cited by 44 · see citing works

Inhibition of SLC7A11 by Sulfasalazine Enhances Osteogenic Differentiation of Mesenchymal Stem Cells by Modulating BMP2/4 Expression and Suppresses Bone Loss in Ovariectomized Mice

Jin, C., Zhang, P., Zhang, M., Zhang, X., Lv, L., Liu, H., Liu, Y., & Zhou, Y. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3009 · Cited by 44 · see citing works

Mesenchymal stem cell-derived extracellular vesicles prevent glioma by blocking M2 polarization of macrophages through a miR-744-5p/TGFB1-dependent mechanism

Liu, L., Cheng, M., Zhang, T., Chen, Y., Wu, Y., & Wang, Q. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09652-7 · Cited by 43 · see citing works

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

Woo, Y., Lee, H.-J., Jung, Y. M., & Jung, Y. (2019) · Journal of Oncology · doi:10.1155/2019/5956867 · Cited by 42 · see citing works

Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice

Li, Y., Yan, B., Wu, Y., Peng, Q., Wei, Y., Chen, Y., Zhang, Y., Ma, N., Xu, Y., & Ma, P. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114848 · Cited by 42 · see citing works

Emerging role of ferroptosis in glioblastoma: Therapeutic opportunities and challenges

Zhuo, S., He, G., Chen, T., Li, X., Liang, Y., Wu, W., Weng, L., Feng, J., Gao, Z., & Yang, K. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.974156 · Cited by 43 · see citing works

Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme

Zhang, Y., Duan, W., Chen, L., Chen, J., Xu, W., Fan, Q., Li, S., Liu, Y., Wang, S., He, Q., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.10.016 · Cited by 40 · see citing works

Review: Molecular characteristics of long‐term epilepsy‐associated tumours (LEATs) and mechanisms for tumour‐related epilepsy (TRE)

Stone, T. J., Rowell, R., Jayasekera, B. A. P., Cunningham, M. O., & Jacques, T. S. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12459 · Cited by 40 · see citing works

Seizures as presenting symptom in patients with glioblastoma

Dührsen, L., Sauvigny, T., Ricklefs, F. L., Mende, K. C., Schaper, M., Matschke, J., Goebell, E., Westphal, M., & Martens, T. (2018) · Epilepsia · doi:10.1111/epi.14615 · Cited by 41 · see citing works

Highlights from the Literature

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Excitotoxic SLC7A11 Expression Is a Marker of Poor Glioblastoma Survival and a Potential Therapeutic Target

Zhang, R. R., Pointer, K. B., & Kuo, J. S. (2015) · Neurosurgery · doi:10.1227/01.neu.0000473809.76102.ee · Cited by 11 · see citing works

Glioma, glutamate (SLC7A11) and seizures—a commentary

Santosh, V., & Palavalasa, S. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.02.18 · Cited by 9 · see citing works

High expression of cystine–glutamate antiporter xCT (SLC7A11) is an independent biomarker for epileptic seizures at diagnosis in glioma

Sørensen, M. F., Heimisdóttir, S. B., Sørensen, M. D., Mellegaard, C. S., Wohlleben, H., Kristensen, B. W., & Beier, C. P. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2785-9 · Cited by 68 · see citing works

The role of glutamate transport and SLC7A11 expression in tumor-associate seizures and survival in patients with malignant gliomas

Keen, J. R., Swanger, S. A., Traynelis, S. F., & Olson, J. J. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.10.23 · Cited by 1 · see citing works