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Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice
Open accessAbstract
Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated with an increase in graft-versus-host disease in mice and humans.
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“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
In the citing paper
“and exposure to certain antibiotic agents at specific times is associated with transplantation-related mortality and GVHD-related mortality.10,16”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
In the citing paper
“Preclinical models have shown that commensal bacteria influence the pathophysiology of GVHD.10,17–20”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
In the citing paper
“Conversely, depletion of gut microbes by broad-spectrum antibiotics prior to T cell therapy can reduce ICB efficacy9 or increase GVHD-related mortality10.”
From A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy (2023) · cites this paper as [10]
In the citing paper
“These antibiotics exert a considerable broad-spectrum, anti-pseudomonal activity, and are also known to severely disrupt the gut microbiome by targeting many anaerobic commensals10,26.”
From A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy (2023) · cites this paper as [10]
In the citing paper
“Dysbiosis and impaired systemic immunity is fairly common in these patients, as they are often treated with concurrent therapies that significantly alter immunity and composition of the gut microbiota”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Shono et al., 2016
In the citing paper
“The gut microbiota may also be impacted by antibiotic treatment for infectious complications during HSCT, with differences in GVHD-associated mortality with different antibiotic regimens”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Shono et al., 2016
In the citing paper
“more recent studies demonstrating detrimental effects of antibiotic use with higher rates of GVHD”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Shono et al., 2016
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Metadata
- Authors
- Shono, Y., Docampo, M. D., Peled, J. U., Perobelli, S. M., Velardi, E., Tsai, J. J., Slingerland, A. E., Smith, O. M., Young, L. F., Gupta, J., Lieberman, S. R., Jay, H. V., Ahr, K. F., Porosnicu Rodriguez, K. A., Xu, K., Calarfiore, M., Poeck, H., Caballero, S., Devlin, S. M., Rapaport, F., Dudakov, J. A., Hanash, A. M., Gyurkocza, B., Murphy, G. F., Gomes, C., Liu, C., Moss, E. L., Falconer, S. B., Bhatt, A. S., Taur, Y., Pamer, E. G., van den Brink, M. R. M., & Jenq, R. R.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- Brigham and Women's Hospital (US)
- Rutgers, The State University of New Jersey (US)
- Stanford University (US)
- Corresponding author
- Shono, Yusuke
- Jenq, Robert R.
- ORCID
- Shono, Yusuke
- Docampo, Melissa D.
- Peled, Jonathan U.
- Perobelli, Suelen M.
- Velardi, Enrico
- Tsai, Jennifer J.
- Slingerland, Ann E.
- Young, Lauren F.
- Lieberman, Sophia R.
- Ahr, Katya F.
- Xu, Ke
- Poeck, Hendrik
- Devlin, Sean M.
- Dudakov, Jarrod A.
- Hanash, Alan M.
- Gyurkocza, Boglarka
- Gomes, Camilla
- Liu, Chen
- Bhatt, Ami S.
- Taur, Ying
- Pamer, Eric G.
- Jenq, Robert R.
- Venue
- Science Translational Medicine
- Published
- 2016-05-18
- Volume
- 8
- Issue
- 339
- Pages
- 339ra71-339ra71
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4991773
- OpenAlex
- W2407774696
- Cited by
- 592
- References
- 78
- Citations by year
- 2026: 49 · 2025: 70 · 2024: 47 · 2023: 61 · 2022: 58 · 2021: 81 · 2020: 65 · 2019: 50 · 2018: 50 · 2017: 47 · 2016: 14
- FWCI
- 51.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- NIH (R01-HL069929, R01-AI100288, R01-AI080455, R01-AI101406, R00-CA176376, R01-HL124112)
- Radiation Effects Research Foundation_National Institute of Allergy and Infectious Diseases
- American Society for Blood and Marrow Transplantation
- Australian National Health
- Medical Research Council
- American Society of Hematology
- DKMS (German Bone Marrow Donor Center) Foundation for Giving Life
- Lymphoma Foundation
- NCI (P30-CA008748)
- NIH Cancer Center Support (P30 CA008748-48)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- graft-versus-host disease, allogeneic hematopoietic stem cell transplantation, broad-spectrum antibiotics, imipenem/cilastatin, piperacillin-tazobactam, aztreonam, cefepime, febrile neutropenia, gut microbiota, Akkermansia muciniphila, intestinal mucus barrier, intestinal barrier function, short-chain fatty acids, regulatory T cells
- MeSH terms
- Gastrointestinal Microbiome, Piperacillin, Tazobactam Drug Combination, Cilastatin, Imipenem Drug Combination, Animals, Anti-Bacterial Agents, Colon, Drug Combinations, Feces, Female, Flow Cytometry, Graft vs Host Disease, Humans, Mice, Inbred C57BL, Penicillanic Acid, Phylogeny, Piperacillin, Transplantation, Homologous, Cilastatin, Imipenem, CD4-Positive T-Lymphocytes, Hematopoietic Stem Cell Transplantation, Mice, Interleukin-23, Verrucomicrobia
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