The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice
Open accessAbstract
Treating neutropenic fever with broad-spectrum antibiotics after allogeneic hematopoietic stem cell transplant is associated with an increase in graft-versus-host disease in mice and humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Each of these outcomes, as well as overall survival, has been associated in single-center studies with features of the intestinal microbiota in the period after hematopoietic-cell transplantation.2–4,8–15”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
In the citing paper
“and exposure to certain antibiotic agents at specific times is associated with transplantation-related mortality and GVHD-related mortality.10,16”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
In the citing paper
“Preclinical models have shown that commensal bacteria influence the pathophysiology of GVHD.10,17–20”
From Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation (2020) · cites this paper as [10]
In the citing paper
“Conversely, depletion of gut microbes by broad-spectrum antibiotics prior to T cell therapy can reduce ICB efficacy9 or increase GVHD-related mortality10.”
From A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy (2023) · cites this paper as [10]
In the citing paper
“These antibiotics exert a considerable broad-spectrum, anti-pseudomonal activity, and are also known to severely disrupt the gut microbiome by targeting many anaerobic commensals10,26.”
From A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy (2023) · cites this paper as [10]
In the citing paper
“Dysbiosis and impaired systemic immunity is fairly common in these patients, as they are often treated with concurrent therapies that significantly alter immunity and composition of the gut microbiota”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Shono et al., 2016
In the citing paper
“The gut microbiota may also be impacted by antibiotic treatment for infectious complications during HSCT, with differences in GVHD-associated mortality with different antibiotic regimens”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Shono et al., 2016
In the citing paper
“more recent studies demonstrating detrimental effects of antibiotic use with higher rates of GVHD”
From The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy (2018) · cites this paper as Shono et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Kraken: ultrafast metagenomic sequence classification using exact alignments
Wood, D. E., & Salzberg, S. L. (2014) · Genome Biology · doi:10.1186/gb-2014-15-3-r46 · Cited by 4,521
Cited by
Sorted by citations
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
Gopalakrishnan, V., Helmink, B. A., Spencer, C. N., Reuben, A., & Wargo, J. A. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.015 · Cited by 1,392
“In addition to the relationship to response and survival, the influence of the gut microbiota has also been studied in the context of toxicity to HSCT therapies—particularly with regard to graft-versus-host disease (GVHD).”
BackgroundResultInfluentialAcute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy
Zeiser, R., & Blazar, B. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1609337 · Cited by 1,347
Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation
Peled, J. U., Gomes, A. L. C., Devlin, S. M., Littmann, E. R., Taur, Y., Sung, A. D., Weber, D., Hashimoto, D., Slingerland, A. E., Slingerland, J. B., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1900623 · Cited by 765
Self-citationDerosa, L., Routy, B., Thomas, A. M., Iebba, V., Zalcman, G., Friard, S., Mazieres, J., Audigier-Valette, C., Moro-Sibilot, D., Goldwasser, F., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01655-5 · Cited by 685
Cullin, N., Azevedo Antunes, C., Straussman, R., Stein-Thoeringer, C. K., & Elinav, E. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.08.006 · Cited by 578
The gut microbiota influences anticancer immunosurveillance and general health
Routy, B., Gopalakrishnan, V., Daillère, R., Zitvogel, L., Wargo, J. A., & Kroemer, G. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0006-2 · Cited by 523
Lazăr, V., Diţu, L.-M., Pîrcălăbioru, G. G., Gheorghe, I., Curuțiu, C., Holban, A. M., Picu, A. A., Petcu, L. M., & Chifiriuc, M. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01830 · Cited by 552
Antibiotic perturbations to the gut microbiome
Fishbein, S. R. S., Mahmud, B., & Dantas, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00933-y · Cited by 440
Lactose drives Enterococcus expansion to promote graft-versus-host disease
Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., et al. (2019) · Science · doi:10.1126/science.aax3760 · Cited by 384
Self-citationModulating the microbiome to improve therapeutic response in cancer
McQuade, J. L., Daniel, C. R., Helmink, B. A., & Wargo, J. A. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30952-5 · Cited by 376
Taur, Y., Coyte, K. Z., Schlüter, J., Robilotti, E. V., Figueroa, C. J., Gjonbalaj, M., Littmann, E. R., Ling, L., Miller, L., Gyaltshen, Y., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap9489 · Cited by 370
Self-citationGut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy
Smith, M., Dai, A., Ghilardi, G., Amelsberg, K. V., Devlin, S. M., Pajarillo, R., Slingerland, J. B., Beghi, S., Herrera, P. S., Giardina, P., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01702-9 · Cited by 349
Self-citationIntestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation
Peled, J. U., Devlin, S. M., Staffas, A., Lumish, M., Khanin, R., Littmann, E. R., Ling, L., Kosuri, S., Maloy, M., Slingerland, J. B., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.70.3348 · Cited by 325
Self-citationGut microbiota injury in allogeneic haematopoietic stem cell transplantation
Shono, Y., & van den Brink, M. R. M. (2018) · Nature reviews. Cancer · doi:10.1038/nrc.2018.10 · Cited by 320
Self-citationChronic graft-versus-host disease: biological insights from preclinical and clinical studies
MacDonald, K. P. A., Hill, G. R., & Blazar, B. R. (2016) · Blood · doi:10.1182/blood-2016-06-686618 · Cited by 304
Roberts, M. B., & Fishman, J. A. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1189 · Cited by 283
Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vétizou, M., Kuns, R. D., Robb, R. J., Zhang, P., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.08.011 · Cited by 258
Weber, D., Jenq, R. R., Peled, J. U., Taur, Y., Hiergeist, A., Koestler, J., Dettmer, K., Weber, M., Wolff, D., Hahn, J., et al. (2017) · Biology of Blood and Marrow Transplantation · doi:10.1016/j.bbmt.2017.02.006 · Cited by 245
Self-citationStein-Thoeringer, C. K., Saini, N. Y., Zamir, E., Blumenberg, V., Schubert, M.-L., Mor, U., Fante, M. A., Schmidt, S., Hayase, E., Hayase, T., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02234-6 · Cited by 255
Self-citationElkrief, A., Derosa, L., Kroemer, G., Zitvogel, L., & Routy, B. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz206 · Cited by 246
Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential
Ioannou, A., Berkhout, M. D., Geerlings, S. Y., & Belzer, C. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01106-1 · Cited by 259
Ullmann, A. J., Schmidt‐Hieber, M., Bertz, H., Heinz, W., Kiehl, M. G., Krüger, W., Mousset, S., Neuburger, S., Neumann, S., Penack, O., et al. (2016) · Annals of Hematology · doi:10.1007/s00277-016-2711-1 · Cited by 214
Introduction to host microbiome symbiosis in health and disease
Malard, F., Dore, J. M., Gaugler, B., & Mohty, M. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00365-4 · Cited by 219
The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease
Staffas, A., da Silva, M. B., & van den Brink, M. R. M. (2016) · Blood · doi:10.1182/blood-2016-09-691394 · Cited by 215
Golob, J. L., Pergam, S. A., Srinivasan, S., Fiedler, T. L., Liu, C., Garcia, K., Mielcarek, M., Ko, D., Aker, S., Marquis, S., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix699 · Cited by 201
Self-citationCurrent Concepts and Advances in Graft-Versus-Host Disease Immunology
Hill, G. R., Betts, B. C., Tkachev, V., Kean, L. S., & Blazar, B. R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102119-073227 · Cited by 207
Acute graft-versus-host disease of the gut: considerations for the gastroenterologist
Naymagon, S., Naymagon, L., Wong, S.-Y., Ko, H. M., Renteria, A. S., Levine, J. E., Colombel, J., & Ferrara, J. L. M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.126 · Cited by 187
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Li, Z., Xiong, W., Zhu, L. W., Wang, J., Zeng, Z., Kołat, D., Li, X., Zhou, D., Xu, X., & Zhao, L.-Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01541-w · Cited by 197
Simms-Waldrip, T. R., Sunkersett, G., Coughlin, L. A., Savani, M. R., Arana, C., Kim, J., Kim, M., Zhan, X., Greenberg, D. E., Xie, Y., et al. (2017) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2017.02.004 · Cited by 176
Markey, K. A., Schlüter, J., Gomes, A. L. C., Littmann, E. R., Pickard, A. J., Taylor, B. P., Giardina, P. A., Weber, D., Dai, A., Docampo, M. D., et al. (2020) · Blood · doi:10.1182/blood.2019003369 · Cited by 171
Self-citationMicrobiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology?
Derosa, L., Routy, B., Desilets, A., Daillère, R., Terrisse, S., Kroemer, G., & Zitvogel, L. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0236 · Cited by 170
Microbial metabolite sensor GPR43 controls severity of experimental GVHD
Fujiwara, H., Docampo, M. D., Riwes, M. M., Peltier, D., Toubai, T., Henig, I. J., Wu, S.-R. J., Kim, S. H., Taylor, A., Brabbs, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06048-w · Cited by 166
Self-citationvan Lier, Y. F., Davids, M., Haverkate, N. J. E., de Groot, P. F., Donker, M. L., Meijer, E., Heubel-Moenen, F. C. J. I., Nur, E., Zeerleder, S. S., Nieuwdorp, M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8926 · Cited by 171
In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes
Chanderraj, R., Baker, J. M., Kay, S. G., Brown, C. A., Hinkle, K. J., Fergle, D. J., McDonald, R. A., Falkowski, N. R., Metcalf, J. D., Kaye, K. S., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.00910-2022 · Cited by 160
Michonneau, D., Latis, E., Curis, E., Dubouchet, L., Ramamoorthy, S., Ingram, B. O., de Latour, R. P., Robin, M., de Fontbrune, F. S., Chevret, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13498-3 · Cited by 149
The varying effects of antibiotics on gut microbiota
Yang, L., Bajinka, O., Jarju, P. O., Tan, Y., Taal, A. M., & Özdemir, G. (2021) · AMB Express · doi:10.1186/s13568-021-01274-w · Cited by 158
Zhao, D., Kim, Y., Jeong, S., Greenson, J. K., Chaudhry, M. S., Hoepting, M., Anderson, E. R., van den Brink, M. R. M., Peled, J. U., Gomes, A. L. C., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99261 · Cited by 145
Self-citationRole of the microbiota in response to and recovery from cancer therapy
Blake, S. J., Wolf, Y., Boursi, B., & Lynn, D. J. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00951-0 · Cited by 151
Spindelboeck, W., Schulz, E., Uhl, B., Kashofer, K., Aigelsreiter, A., Zinke-Cerwenka, W., Mulabecirovic, A., Kump, P. K., Halwachs, B., Gorkiewicz, G., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.154351 · Cited by 134
Battipaglia, G., Malard, F., Rubio, M., Ruggeri, A., Mamez, A., Brissot, É., Giannotti, F., Duléry, R., Joly, A. C., Baylatry, M. T., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.198549 · Cited by 132
Davidovics, Z. H., Michail, S. K., Nicholson, M. R., Kociolek, L. K., Pai, N., Hansen, R., Schwerd, T., Maspons, A., Shamir, R., Szajewska, H., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002205 · Cited by 132
New and emerging therapies for acute and chronic graft versus host disease
Hill, L. C., Alousi, A. M., Kebriaei, P., Mehta, R. S., Rezvani, K., & Shpall, E. J. (2017) · Therapeutic Advances in Hematology · doi:10.1177/2040620717741860 · Cited by 121
Ingham, A. C., Kielsen, K., Cilieborg, M. S., Lund, O., Holmes, S., Aarestrup, F. M., Müller, K., & Pamp, S. J. (2019) · Microbiome · doi:10.1186/s40168-019-0745-z · Cited by 116
Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease
Hayase, E., Hayase, T., Jamal, M. A., Miyama, T., Chang, C., Ortega, M. R., Ahmed, S., Karmouch, J. L., Sanchez, C. A., Brown, A. N., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.007 · Cited by 116
Self-citationZeiser, R., Socié, G., & Blazar, B. R. (2016) · British Journal of Haematology · doi:10.1111/bjh.14295 · Cited by 117
The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future
Andermann, T. M., Peled, J. U., Ho, C. M., Reddy, P. R., Riches, M., Storb, R. F., Teshima, T., van den Brink, M. R. M., Alousi, A. M., Balderman, S., et al. (2018) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2018.02.009 · Cited by 113
Self-citationCharacterization of oral and gut microbiome temporal variability in hospitalized cancer patients
Galloway-Peña, J., Smith, D. P., Sahasrabhojane, P. V., Wadsworth, W. D., Fellman, B. M., Ajami, N. J., Shpall, E. J., Daver, N. G., Guindani, M., Petrosino, J. F., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0409-1 · Cited by 118
Bajic, D., Niemann, A., Hillmer, A.-K., Mejías‐Luque, R., Bluemel, S., Docampo, M. D., Funk, M. C., Tonin, E., Boutros, M., Schnabl, B., et al. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa065 · Cited by 118
Self-citationThe gut microbiota and graft-versus-host disease
Fredricks, D. N. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125797 · Cited by 115
Snider, E. J., Compres, G., Freedberg, D. E., Khiabanian, H., Nobel, Y. R., Stump, S., Uhlemann, A., Lightdale, C. J., & Abrams, J. A. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0008 · Cited by 108
Pettigrew, M. M., Gent, J. F., Kong, Y., Halpin, A. L., Pineles, L. L., Harris, A. D., & Johnson, J. K. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy936 · Cited by 106
Weber, D., Hiergeist, A., Weber, M., Dettmer, K., Wolff, D., Hahn, J., Herr, W., Gessner, A., & Holler, E. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciy711 · Cited by 92
A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD
Sofi, M. H., Wu, Y., Ticer, T. D., Schutt, S. D., Bastian, D. A., Choi, H.-J., Tian, L., Mealer, C., Liu, C., Westwater, C., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.136841 · Cited by 97
Self-citationLiao, C., Rolling, T., Djuković, A., Fei, T., Mishra, V., Liu, H., Lindberg, C., Dai, L., Zhai, B., Peled, J. U., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01680-3 · Cited by 98
Self-citationHan, L., Jin, H., Zhou, L., Zhang, X., Fan, Z., Dai, M., Lin, Q., Huang, F., Xuan, L., Zhang, H., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00669 · Cited by 97
Advances in understanding the pathogenesis of graft‐versus‐host disease
Zeiser, R. (2019) · British Journal of Haematology · doi:10.1111/bjh.16190 · Cited by 91
Ingham, A. C., Kielsen, K., Mordhorst, H., Ifversen, M., Aarestrup, F. M., Müller, K., & Pamp, S. J. (2021) · Microbiome · doi:10.1186/s40168-021-01100-2 · Cited by 91
Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment
Pouncey, A. L., Scott, A. J., Alexander, J. L., Marchesi, J. R., & Kinross, J. K. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.868 · Cited by 89
Akkermansia in the gastrointestinal tract as a modifier of human health
Panzetta, M. E., & Valdivia, R. H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2406379 · Cited by 97
Elkrief, A., Pidgeon, R., Vareki, S. M., Messaoudene, M., Castagner, B., & Routy, B. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01211-7 · Cited by 99
Dandoy, C. E., Ardura, M. I., Papanicolaou, G. A., & Auletta, J. J. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.14 · Cited by 85
The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease
Koyama, M., & Hill, G. R. (2019) · Blood · doi:10.1182/blood.2019000823 · Cited by 86
Yoshifuji, K., Inamoto, K., Kiridoshi, Y., Takeshita, K., Sasajima, S., Shiraishi, Y., Yamashita, Y. T., Nisaka, Y., Ogura, Y., Takeuchi, R., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002604 · Cited by 84
Rolling, T., Zhai, B., Gjonbalaj, M., Tosini, N. L., Yasuma-Mitobe, K., Fontana, E., Amoretti, L. A., Wright, R. J., Ponce, D. M., Perales, M., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00989-7 · Cited by 81
Self-citationRashidi, A., Ebadi, M., Rehman, T. U., Elhusseini, H., Kazadi, D., Halaweish, H., Khan, M. H., Hoeschen, A. L., Cao, Q., Luo, X., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.22.02366 · Cited by 84
Tissue tolerance: a distinct concept to control acute GVHD severity
Wu, S.-R. J., & Reddy, P. R. (2017) · Blood · doi:10.1182/blood-2016-09-740431 · Cited by 82
Can we harness the microbiota to enhance the efficacy of cancer immunotherapy?
Finlay, B. B., Goldszmid, R., Honda, K., Trinchieri, G., Wargo, J., & Zitvogel, L. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0374-6 · Cited by 81
Gut Microbiota Influence in Hematological Malignancies: From Genesis to Cure
Uribe‐Herranz, M., Klein-González, N., Rodríguez‐Lobato, L. G., Juan, M., & de Larrea, C. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031026 · Cited by 84
da Silva, M. B., Ponce, D. M., Dai, A., Devlin, S. M., Gomes, A. L. C., Moore, G., Slingerland, J. B., Shouval, R., Armijo, G. K., DeWolf, S., et al. (2022) · Blood · doi:10.1182/blood.2021015352 · Cited by 81
Self-citationGanetsky, A., Han, J., Hughes, M. E., Babushok, D. V., Frey, N. V., Gill, S. I., Hexner, E. O., Loren, A. W., Luger, S. M., Mangan, J. K., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy822 · Cited by 79
Immunopathology and biology-based treatment of steroid-refractory graft-versus-host disease
Toubai, T., & Magenau, J. M. (2020) · Blood · doi:10.1182/blood.2019000953 · Cited by 79
Mortality of Patients With Sepsis Administered Piperacillin-Tazobactam vs Cefepime
Chanderraj, R., Admon, A. J., He, Y., Nuppnau, M., Albin, O. R., Prescott, H. C., Dickson, R. P., & Sjoding, M. W. (2024) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2024.0581 · Cited by 80
Golob, J. L., DeMeules, M. M., Loeffelholz, T., Quinn, Z. Z., Dame, M. K., Silvestri, S. S., Wu, M. C., Schmidt, T. M., Fiedler, T. L., Hoostal, M. J., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2019000362 · Cited by 76
Hueso, T., Ekpe, K., Mayeur, C., Gatse, A., Curt, M. J.-C., Gricourt, G., Rodriguez, C., Burdet, C., Ulmann, G., Neut, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1800897 · Cited by 76
Routy, B., Letendre, C., Enot, D., Chénard-Poirier, M., Mehraj, V., Séguin, N. C., Guenda, K., Gagnon, K., Woerther, P.-L., Ghez, D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1258506 · Cited by 75
Ilett, E. E., Jørgensen, M., Noguera-Julián, M., Nørgaard, J. C., Daugaard, G., Helleberg, M., Paredes, R., Murray, D. D., Lundgren, J. D., MacPherson, C. R., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020002677 · Cited by 78
Liu, C., Frank, D. N., Horch, M., Chau, S., Ir, D., Horch, E. A., Tretina, K., van Besien, K., Lozupone, C., & Nguyen, V. (2017) · Bone Marrow Transplantation · doi:10.1038/bmt.2017.200 · Cited by 76
Self-citationÜstün, C., Young, J. H., Papanicolaou, G. A., Kim, S., Ahn, K. W., Chen, M., Abdel‐Azim, H., Aljurf, M. D., Beitinjaneh, A., Brown, V. I., et al. (2018) · Bone Marrow Transplantation · doi:10.1038/s41409-018-0401-4 · Cited by 73
Mancini, N., Greco, R., Pasciuta, R., Barbanti, M. C., Pini, G. M., Morrow, O., Morelli, M., Vago, L., Clementi, N., Giglio, F., et al. (2017) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofx215 · Cited by 71
Fecal Microbiota Transplantation: Current Status in Treatment of GI and Liver Disease
Vaughn, B. P., Rank, K. M., & Khoruts, A. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.07.026 · Cited by 72
Roles of the intestinal microbiota and microbial metabolites in acute GVHD
Lin, D., Hu, B., Li, P., Zhao, Y., Xu, Y., & Wu, D. (2021) · Experimental Hematology & Oncology · doi:10.1186/s40164-021-00240-3 · Cited by 71
Gut microbiome in pediatric acute leukemia: from predisposition to cure
Masetti, R., Muratore, E., Leardini, D., Zama, D., Turroni, S., Brigidi, P., Esposito, S., & Pession, A. (2021) · Blood Advances · doi:10.1182/bloodadvances.2021005129 · Cited by 71
A review of infectious complications after haploidentical hematopoietic stem cell transplantations
Atilla, E., Atilla, P. A., Bozdağ, S. C., & Demirer, T. (2017) · Infection · doi:10.1007/s15010-017-1016-1 · Cited by 71
Lee, S., Lim, J., Ryu, D., Kim, T., Park, S. S., Jeon, Y., Yoon, J., Cho, B., Eom, K., Kim, Y., et al. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.06.001 · Cited by 69
Lindner, S., Miltiadous, O., Ramos, R. J. J. F., Paredes, J., Kousa, A. I., Dai, A., Fei, T., Lauder, E., Frame, J., Waters, N. R., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01617-w · Cited by 74
Self-citationFernandez, E., Wargo, J. A., & Helmink, B. A. (2025) · JAMA · doi:10.1001/jama.2025.2191 · Cited by 82
New Insights into Graft-Versus-Host Disease and Graft Rejection
Perkey, E., & Maillard, I. P. (2017) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043720 · Cited by 69
Prasad, R., Rehman, A., Rehman, L., Darbaniyan, F., Blumenberg, V., Schubert, M., Mor, U., Zamir, E., Schmidt, S., Hayase, T., et al. (2024) · Blood · doi:10.1182/blood.2024025366 · Cited by 69
Self-citationGut Microbiome Modulates Response to Cancer Immunotherapy
Khan, M. A. W., Ologun, G. O., Arora, R., McQuade, J. L., & Wargo, J. A. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06111-x · Cited by 69
Fungal lysozyme leverages the gut microbiota to curb DSS-induced colitis
Larsen, I., Jensen, B. A. H., Bonazzi, E., Choi, B. S.-Y., Kristensen, N. N., Schmidt, E. G. W., Sünderhauf, A., Morin, L., Olsen, P., Hansen, L. B. S., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1988836 · Cited by 66
Clinical Evidence for the Microbiome in Inflammatory Diseases
Slingerland, A. E., Schwabkey, Z. I., Wiesnoski, D. H., & Jenq, R. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00400 · Cited by 65
Self-citationMcQuade, J. L., Ologun, G. O., Arora, R., & Wargo, J. A. (2020) · Current Oncology Reports · doi:10.1007/s11912-020-00913-y · Cited by 63
Papanicolaou, G. A., Üstün, C., Young, J. H., Chen, M., Kim, S., Ahn, K. W., Komanduri, K. V., Lindemans, C. A., Auletta, J. J., Riches, M., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz031 · Cited by 62
Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment
Schwabkey, Z. I., Wiesnoski, D. H., Chang, C., Tsai, W.-B., Pham, D., Ahmed, S., Hayase, T., Ortega, M. R., El-Himri, R. K., Sanchez, C. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo3445 · Cited by 61
Self-citationKusakabe, S., Fukushima, K., Maeda, T., Motooka, D., Nakamura, S., Fujita, J., Yokota, T., Shibayama, H., Oritani, K., & Kanakura, Y. (2019) · British Journal of Haematology · doi:10.1111/bjh.16205 · Cited by 62
de Koning, C. C. H., Nierkens, S., & Boelens, J. J. (2016) · Blood · doi:10.1182/blood-2016-06-724005 · Cited by 60
Docampo, M. D., da Silva, M. B., Lazrak, A., Nichols, K. B., Lieberman, S. R., Slingerland, A. E., Armijo, G. K., Shono, Y., Nguyen, C. L., Monette, S., et al. (2021) · Blood · doi:10.1182/blood.2021010719 · Cited by 60
Self-citationAllogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease
van Lier, Y. F., Vos, J., Blom, B., & Hazenberg, M. D. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2178805 · Cited by 66
Empirical antibiotic therapy for sepsis: save the anaerobic microbiota
Kullberg, R. F. J., Haak, B. W., Chanderraj, R., Prescott, H. C., Dickson, R. P., & Wiersinga, W. J. (2024) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(24)00257-1 · Cited by 64
Gut microbiome homeostasis and the future of probiotics in cancer immunotherapy
Singh, A., Alexander, S., & Martin, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1114499 · Cited by 68
Metadata
- Authors
- Shono, Y., Docampo, M. D., Peled, J. U., Perobelli, S. M., Velardi, E., Tsai, J. J., Slingerland, A. E., Smith, O. M., Young, L. F., Gupta, J., Lieberman, S. R., Jay, H. V., Ahr, K. F., Porosnicu Rodriguez, K. A., Xu, K., Calarfiore, M., Poeck, H., Caballero, S., Devlin, S. M., Rapaport, F., Dudakov, J. A., Hanash, A. M., Gyurkocza, B., Murphy, G. F., Gomes, C., Liu, C., Moss, E. L., Falconer, S. B., Bhatt, A. S., Taur, Y., Pamer, E. G., van den Brink, M. R. M., & Jenq, R. R.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
- Program in Dermatopathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- Brigham and Women's Hospital (US)
- Rutgers, The State University of New Jersey (US)
- Stanford University (US)
- Corresponding author
- Shono, Yusuke
- Jenq, Robert R.
- ORCID
- Shono, Yusuke
- Docampo, Melissa D.
- Peled, Jonathan U.
- Perobelli, Suelen M.
- Velardi, Enrico
- Tsai, Jennifer J.
- Slingerland, Ann E.
- Young, Lauren F.
- Lieberman, Sophia R.
- Ahr, Katya F.
- Xu, Ke
- Poeck, Hendrik
- Devlin, Sean M.
- Dudakov, Jarrod A.
- Hanash, Alan M.
- Gyurkocza, Boglarka
- Gomes, Camilla
- Liu, Chen
- Bhatt, Ami S.
- Taur, Ying
- Pamer, Eric G.
- Jenq, Robert R.
- Venue
- Science Translational Medicine
- Published
- 2016-05-18
- Volume
- 8
- Issue
- 339
- Pages
- 339ra71-339ra71
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4991773
- OpenAlex
- W2407774696
- Cited by
- 592
- References
- 78
- Citations by year
- 2026: 49 · 2025: 70 · 2024: 47 · 2023: 61 · 2022: 58 · 2021: 81 · 2020: 65 · 2019: 50 · 2018: 50 · 2017: 47 · 2016: 14
- FWCI
- 51.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- NIH (R01-HL069929, R01-AI100288, R01-AI080455, R01-AI101406, R00-CA176376, R01-HL124112)
- Radiation Effects Research Foundation_National Institute of Allergy and Infectious Diseases
- American Society for Blood and Marrow Transplantation
- Australian National Health
- Medical Research Council
- American Society of Hematology
- DKMS (German Bone Marrow Donor Center) Foundation for Giving Life
- Lymphoma Foundation
- NCI (P30-CA008748)
- NIH Cancer Center Support (P30 CA008748-48)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- graft-versus-host disease, allogeneic hematopoietic stem cell transplantation, broad-spectrum antibiotics, imipenem/cilastatin, piperacillin-tazobactam, aztreonam, cefepime, febrile neutropenia, gut microbiota, Akkermansia muciniphila, intestinal mucus barrier, intestinal barrier function, short-chain fatty acids, regulatory T cells
- MeSH terms
- Gastrointestinal Microbiome, Piperacillin, Tazobactam Drug Combination, Cilastatin, Imipenem Drug Combination, Animals, Anti-Bacterial Agents, Colon, Drug Combinations, Feces, Female, Flow Cytometry, Graft vs Host Disease, Humans, Mice, Inbred C57BL, Penicillanic Acid, Phylogeny, Piperacillin, Transplantation, Homologous, Cilastatin, Imipenem, CD4-Positive T-Lymphocytes, Hematopoietic Stem Cell Transplantation, Mice, Interleukin-23, Verrucomicrobia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
