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BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
Open accessAbstract
BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.
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“BET inhibition exerted a strong protective effect on left ventricular ejection fraction (Fig. 1B)4,6-10.”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [8]
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“As BET proteins are transcriptional co-activators and their inhibition is associated with protection in heart failure models6-8”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [8]
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Metadata
- Authors
- Duan, Q., McMahon, S., Anand, P., Shah, H., Thomas, S., Salunga, H. T., Huang, Y., Zhang, R., Sahadevan, A., Lemieux, M. E., Brown, J. D., Srivastava, D., Bradner, J. E., McKinsey, T. A., & Haldar, S. M.
- Affiliations
- Gladstone Institutes (US)
- University Hospitals of Cleveland (US)
- 1QBit (CA)
- Vanderbilt University (US)
- Harvard University (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Duan, Qiming
- McMahon, Sarah
- Haldar, Saptarsi M.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-05-17
- Volume
- 9
- Issue
- 390
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5544253
- OpenAlex
- W2616008841
- Cited by
- 262
- References
- 70
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 20 · 2023: 28 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 33 · 2018: 23 · 2017: 8
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-02-19)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (award298115, HL116848, award298112, HL127240)
- National Institute of Diabetes and Digestive and Kidney Diseases (award298116, DK093821)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure, BET bromodomain inhibition, BRD4, JQ1, epigenetic therapy, cardiac hypertrophy, NF-κB signaling, TGF-beta signaling, myocarditis, myocardial fibrosis, pressure overload, myocardial infarction, iPSC-derived cardiomyocytes, chromatin regulation, gene regulatory networks
- MeSH terms
- Bromodomain Containing Proteins, Animals, Azepines, Cardiomegaly, Heart Failure, Humans, Inflammation, Male, Mice, Inbred C57BL, Proteins, Triazoles, Signal Transduction, Transforming Growth Factor beta, NF-kappa B, Myocytes, Cardiac, Mice, Gene Regulatory Networks, Induced Pluripotent Stem Cells
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