The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
Open accessAbstract
BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.
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“BET inhibition exerted a strong protective effect on left ventricular ejection fraction (Fig. 1B)4,6-10.”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [8]
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“As BET proteins are transcriptional co-activators and their inhibition is associated with protection in heart failure models6-8”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [8]
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Cites
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Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Kim, D., Pertea, G., Trapnell, C., Pimentel, H., Kelley, R., & Salzberg, S. L. (2013) · Genome Biology · doi:10.1186/gb-2013-14-4-r36 · Cited by 12,668
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Causal analysis approaches in Ingenuity Pathway Analysis
Krämer, A., Green, J., Pollard, J., & Tugendreich, S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt703 · Cited by 5,724
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Selective inhibition of BET bromodomains
Filippakopoulos, P., Qi, J., Picaud, S., Shen, Y., Smith, W. B., Fedorov, O., Morse, E. M., Keates, T., Hickman, T. T., Felletar, I., et al. (2010) · Nature · doi:10.1038/nature09504 · Cited by 4,262
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Research works printed but not linked: 1
- National Research Council Guide for the Care and Use of Laboratory Animals (National Acadmies Press 8th ed. 2011).
Cited by
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Role of the gut microbiota in nutrition and health
Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ · doi:10.1136/bmj.k2179 · Cited by 2,375
Microglia in Alzheimer’s disease
Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935
Frangogiannis, N. G. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa324 · Cited by 1,229
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
Gilan, O., Rioja, I., Knezevic, K., Bell, M. J., Yeung, M. M., Harker, N., Lam, E. Y. N., Chung, C., Bamborough, P., Petretich, M., et al. (2020) · Science · doi:10.1126/science.aaz8455 · Cited by 453
Bromodomains: a new target class for drug development
Cochran, A. G., Conery, A. R., & Sims, R. J. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0030-7 · Cited by 450
Metadata
- Authors
- Duan, Q., McMahon, S., Anand, P., Shah, H., Thomas, S., Salunga, H. T., Huang, Y., Zhang, R., Sahadevan, A., Lemieux, M. E., Brown, J. D., Srivastava, D., Bradner, J. E., McKinsey, T. A., & Haldar, S. M.
- Affiliations
- Gladstone Institutes (US)
- University Hospitals of Cleveland (US)
- 1QBit (CA)
- Vanderbilt University (US)
- Harvard University (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Duan, Qiming
- McMahon, Sarah
- Haldar, Saptarsi M.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-05-17
- Volume
- 9
- Issue
- 390
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5544253
- OpenAlex
- W2616008841
- Cited by
- 262
- References
- 70
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 20 · 2023: 28 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 33 · 2018: 23 · 2017: 8
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-02-19)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (award298115, HL116848, award298112, HL127240)
- National Institute of Diabetes and Digestive and Kidney Diseases (award298116, DK093821)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure, BET bromodomain inhibition, BRD4, JQ1, epigenetic therapy, cardiac hypertrophy, NF-κB signaling, TGF-beta signaling, myocarditis, myocardial fibrosis, pressure overload, myocardial infarction, iPSC-derived cardiomyocytes, chromatin regulation, gene regulatory networks
- MeSH terms
- Bromodomain Containing Proteins, Animals, Azepines, Cardiomegaly, Heart Failure, Humans, Inflammation, Male, Mice, Inbred C57BL, Proteins, Triazoles, Signal Transduction, Transforming Growth Factor beta, NF-kappa B, Myocytes, Cardiac, Mice, Gene Regulatory Networks, Induced Pluripotent Stem Cells
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