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Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers
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THBS2 and CA19-9 markers in human blood improve detection of pancreatic ductal adenocarcinoma.
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“Such biomarker “panels” often build upon CA 19-9 and demonstrate improved performance in early-stage disease compared with CA 19-9 alone.40–43”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [43]
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Cites
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179
Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455
Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880
Distant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502
Phases of Biomarker Development for Early Detection of Cancer
Pepe, M. S., Etzioni, R., Feng, Z., Potter, J. D., Thompson, M. L., Thornquist, M., Winget, M., & Yasui, Y. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.14.1054 · Cited by 1,686
Research works printed but not linked: 2
- 10.1373/49.1.7 · DOI · Paper page
- 10.1016/j.gastro.2005.05.007 · DOI · Paper page
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Sugimoto, N., Noura, S., Kato, T., Yoshioka, S., Hata, T., Naito, A., Tei, M., Tamagawa, H., Komori, T., Ide, Y., et al. (2024) · Cancers · doi:10.3390/cancers17010091 · Cited by 1
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Zhao, Z., Xu, Y., Xu, S., Zhang, L., & Li, J. (2026) · Microchimica Acta · doi:10.1007/s00604-026-08173-6 · Cited by 1
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Nene, N. R., Ney, A., Nazarenko, T., Blyuss, O. B., Johnston, H. E., Whitwell, H. J., Sedlak, E., Gentry‐Maharaj, A., Costello, E., Greenhalf, W., et al. (2021) · medRxiv · doi:10.1101/2021.12.02.21267187 · Cited by 1
Liang, C.-H., Ye, H., Xu, H., Fang, C., Lian, J.-P., Chen, Y.-Q., Wang, W.-T., & He, B. (2026) · Advanced Biotechnology · doi:10.1007/s44307-026-00141-8
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Majumder, S., Taylor, W. R., Foote, P. H., Berger, C. K., Wu, C. W., Mahoney, D. W., Bamlet, W. R., Burger, K. N., Postier, N., de la Fuente, J., et al. (2023) · doi:10.1158/1078-0432.c.6531204
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Qin, J., Shi, M., Ren, L., Jiang, L., & Shen, B. (2023) · Research Square · doi:10.21203/rs.3.rs-3037921/v1
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Wu, H., Guo, S., Liu, X., Li, Y., Su, Z., He, Q., Liu, X., Zhang, Z., Yu, L., Shi, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21629032
Xiong, F., Wu, G., Wang, B., & Chen, Y. (2021) · Figshare · doi:10.6084/m9.figshare.15109914
Wu, H., Guo, S., Liu, X., Li, Y., Su, Z., He, Q., Liu, X., Zhang, Z., Yu, L., Shi, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21629026
Wu, H., Guo, S., Liu, X., Li, Y., Su, Z., He, Q., Liu, X., Zhang, Z., Yu, L., Shi, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21629029
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Gupta, P., Murad, R., Ling, L., Zhang, Y., Duong‐Polk, K., Maganti, S., Galapate, C. M., & Commisso, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.08.652966
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Lee, R., & Park, Y. I. (2025) · Springer eBooks · doi:10.1007/978-3-032-00763-6_326
Wu, H., Guo, S., Liu, X., Li, Y., Su, Z., He, Q., Liu, X., Zhang, Z., Yu, L., Shi, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21629023
Wu, H., Guo, S., Liu, X., Li, Y., Su, Z., He, Q., Liu, X., Zhang, Z., Yu, L., Shi, X., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21629020
Xiong, F., Wu, G.-H., Wang, B., & Chen, Y.-J. (2021) · Figshare · doi:10.6084/m9.figshare.15109917
Bhatti, N., Hajam, Y. A., & Malhotra, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-23908-3.00006-x
Moldovan, S. A., Iacobescu, M., Moiș, E. I., Graur, F., Furcea, L., Zaharie, F. V., Ciocan, A., Soporan, M.-A., Pralea, I.-E., Mirel, S., et al. (2026) · Medicina · doi:10.3390/medicina62030605
Souche, F.-R. (2021) · theses.fr (ABES) · doi:10.70675/9c3ebbe0zf293z4cebz8008zded4724282b7
Jain, K., Kumar, S., Bhat, M. K., Khatoon, Z., & Singh, N. K. (2026) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2026.100807
Wieczorek, M. M., Wieczorek, Ł., Borkowska, A., & Małecka-Wojciesko, E. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1866001
Miyazawa, M., Takatori, H., Nishitani, M., Takata, N., Seki, A., Nio, K., Iida, N., Shimakami, T., & Yamashita, T. (2026) · Scientific Reports · doi:10.1038/s41598-026-58684-8
Ren, Z., Li, Z., Wang, J., Liu, Y., Chen, L., Su, Y., Zhao, L., & Liu, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156951
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Metadata
- Authors
- Kim, J., Bamlet, W. R., Oberg, A. L., Chaffee, K. G., Donahue, G., Cao, X.-J., Chari, S., Garcia, B. A., Petersen, G. M., & Zaret, K. S.
- Affiliations
- Abramson Cancer Center (US)
- Mayo Clinic (US)
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
- University of Pennsylvania (US)
- Corresponding author
- Zaret, Kenneth S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-07-12
- Volume
- 9
- Issue
- 398
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5727893
- OpenAlex
- W2734646423
- Cited by
- 269
- References
- 57
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 24 · 2023: 22 · 2022: 39 · 2021: 52 · 2020: 39 · 2019: 23 · 2018: 29 · 2017: 6
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense (award308650, BC123187P1)
- NIH Office of the Director (award307521, DK108288-02, award308646, R01GM36477, award308647, P30DK050306, award308649, P50CA102701, award308648, R01CA208517, award308651, P30DK19525)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Keywords
- pancreatic ductal adenocarcinoma, thrombospondin-2, CA19-9, early cancer detection, plasma biomarkers, tumor staging
- MeSH terms
- Thrombospondin 2, Adenocarcinoma, Aged, Demography, Female, Humans, Male, Middle Aged, Biomarkers, Tumor, Reproducibility of Results, Case-Control Studies, CA-19-9 Antigen, Thrombospondins, Carcinoma, Pancreatic Ductal, Early Detection of Cancer
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