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Detection of early pancreatic ductal adenocarcinoma with thrombospondin-2 and CA19-9 blood markers
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THBS2 and CA19-9 markers in human blood improve detection of pancreatic ductal adenocarcinoma.
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“Such biomarker “panels” often build upon CA 19-9 and demonstrate improved performance in early-stage disease compared with CA 19-9 alone.40–43”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [43]
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Cao, L., Huang, C., Cui Zhou, D., Hu, Y., Lih, T. M., Savage, S. R., Krug, K., Clark, D. J., Schnaubelt, M., Chen, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.08.023 · Cited by 578
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Metadata
- Authors
- Kim, J., Bamlet, W. R., Oberg, A. L., Chaffee, K. G., Donahue, G., Cao, X.-J., Chari, S., Garcia, B. A., Petersen, G. M., & Zaret, K. S.
- Affiliations
- Abramson Cancer Center (US)
- Mayo Clinic (US)
- Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
- University of Pennsylvania (US)
- Corresponding author
- Zaret, Kenneth S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-07-12
- Volume
- 9
- Issue
- 398
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5727893
- OpenAlex
- W2734646423
- Cited by
- 269
- References
- 57
- Citations by year
- 2026: 18 · 2025: 17 · 2024: 24 · 2023: 22 · 2022: 39 · 2021: 52 · 2020: 39 · 2019: 23 · 2018: 29 · 2017: 6
- FWCI
- 11.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense (award308650, BC123187P1)
- NIH Office of the Director (award307521, DK108288-02, award308646, R01GM36477, award308647, P30DK050306, award308649, P50CA102701, award308648, R01CA208517, award308651, P30DK19525)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Keywords
- pancreatic ductal adenocarcinoma, thrombospondin-2, CA19-9, early cancer detection, plasma biomarkers, tumor staging
- MeSH terms
- Thrombospondin 2, Adenocarcinoma, Aged, Demography, Female, Humans, Male, Middle Aged, Biomarkers, Tumor, Reproducibility of Results, Case-Control Studies, CA-19-9 Antigen, Thrombospondins, Carcinoma, Pancreatic Ductal, Early Detection of Cancer
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