Cited by 320Circadian rhythm and melatoninGene expression and cancer classificationPharmacogenetics and Drug Metabolism

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A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

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Ruben, Marc D., Wu, Gang, Smith, David F., Schmidt, Robert E., Francey, Lauren J., Lee, Yin Yeng, Anafi, Ron C., Hogenesch, John B.·2018·Science Translational Medicine

DOI 10.1126/scitranslmed.aat8806PMC PMC8961342

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Abstract

Bioinformatic analyses of human tissue samples were used to build a database of rhythmically expressed genes across the body.

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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
DrugBank 5.0: a major update to the DrugBank database for 2018
Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1037 · Cited by 8,404
UpSetR: an R package for the visualization of intersecting sets and their properties
Conway, J. R., Lex, A., & Gehlenborg, N. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx364 · Cited by 3,586
A circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304
Self-citation
tidyverse: Easily Install and Load the 'Tidyverse'
Wickham, H. (2016) · doi:10.32614/cran.package.tidyverse · Cited by 1,520
Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
Mure, L. S., Le, H. D., Benegiamo, G., Chang, M. W., Ríos, L., Jillani, N., Ngotho, M., Kariuki, T., Dkhissi‐Benyahya, O., Cooper, H. M., et al. (2018) · Science · doi:10.1126/science.aao0318 · Cited by 791
Circadian variation in the incidence of sudden cardiac death in the framingham heart study population
Willich, S. N., Levy, D., Rocco, M. B., Tofler, G. H., Stone, P. H., & Muller, J. E. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91027-7 · Cited by 653
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
McDonald, M. J., & Rosbash, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00545-1 · Cited by 614
Adenosine and Adenosine Receptors in the Cardiovascular System: Biochemistry, Physiology, and Pharmacology
Shryock, J. C., & Belardinelli, L. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00256-7 · Cited by 578

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Additional file 3 of A population-based gene expression signature of molecular clock phase from a single epidermal sample
Wu, G., Ruben, M. D., Francey, L. J., Smith, D. F., Sherrill, J. D., Oblong, J. E., Mills, K. J., & Hogenesch, J. B. (2020) · Figshare · doi:10.6084/m9.figshare.12845580
Self-citation
Additional file 4 of A population-based gene expression signature of molecular clock phase from a single epidermal sample
Wu, G., Ruben, M. D., Francey, L. J., Smith, D. F., Sherrill, J. D., Oblong, J. E., Mills, K. J., & Hogenesch, J. B. (2020) · Figshare · doi:10.6084/m9.figshare.12845583
Self-citation
Additional file 2 of A population-based gene expression signature of molecular clock phase from a single epidermal sample
Wu, G., Ruben, M. D., Francey, L. J., Smith, D. F., Sherrill, J. D., Oblong, J. E., Mills, K. J., & Hogenesch, J. B. (2020) · Figshare · doi:10.6084/m9.figshare.12845577
Self-citation
Additional file 6 of A population-based gene expression signature of molecular clock phase from a single epidermal sample
Wu, G., Ruben, M. D., Francey, L. J., Smith, D. F., Sherrill, J. D., Oblong, J. E., Mills, K. J., & Hogenesch, J. B. (2020) · Figshare · doi:10.6084/m9.figshare.12845589
Self-citation
Additional file 5 of A population-based gene expression signature of molecular clock phase from a single epidermal sample
Wu, G., Ruben, M. D., Francey, L. J., Smith, D. F., Sherrill, J. D., Oblong, J. E., Mills, K. J., & Hogenesch, J. B. (2020) · Figshare · doi:10.6084/m9.figshare.12845586
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Prokop, J. W., Bilinovich, S. M., Tokarski, E., Vishweswaraiah, S., Vanderweele, S., Das, A. S., Chhetri, S. B., Dao, A., Arora, S., Goodyke, A., et al. (2025) · Function · doi:10.1152/function.019.2025

Authors: Ruben, M. D., Wu, G., Smith, D. F., Schmidt, R. E., Francey, L. J., Lee, Y. Y., Anafi, R. C., & Hogenesch, J. B.
Affiliations: Cincinnati Children's Hospital Medical Center (US)
University of Pennsylvania (US)
Corresponding author: Hogenesch, John B.
ORCID: Ruben, Marc D.
Wu, Gang
Smith, David F.
Schmidt, Robert E.
Francey, Lauren J.
Lee, Yin Yeng
Anafi, Ron C.
Hogenesch, John B.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-09-12
Volume: 10
Issue: 458
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aat8806
PMC: PMC8961342
OpenAlex: W2889589921
Cited by: 314
References: 44
Citations by year: 2026: 30 · 2025: 33 · 2024: 45 · 2023: 55 · 2022: 43 · 2021: 44 · 2020: 37 · 2019: 22 · 2018: 5
FWCI: 15.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Human Genome Research Institute (2R01HG005220)
National Institute of Neurological Disorders and Stroke (2R01NS054794)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: circadian rhythm, tissue-specific gene expression, rhythmic gene expression, circadian clock, drug metabolism genes, drug transporters, therapeutic target, circadian medicine, drug response
MeSH terms: Adult, Aged, Circadian Rhythm, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Organ Specificity, Drug Delivery Systems, Databases, Genetic, Young Adult

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A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

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