A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482

DrugBank 5.0: a major update to the DrugBank database for 2018

Wishart, D. S., Feunang, Y. D., Guo, A. C., Lo, E. J., Marcu, A., Grant, J. R., Sajed, T., Johnson, D., Li, C., Sayeeda, Z., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1037 · Cited by 8,404

UpSetR: an R package for the visualization of intersecting sets and their properties

Conway, J. R., Lex, A., & Gehlenborg, N. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btx364 · Cited by 3,586

A circadian gene expression atlas in mammals: Implications for biology and medicine

Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304

tidyverse: Easily Install and Load the 'Tidyverse'

Wickham, H. (2016) · doi:10.32614/cran.package.tidyverse · Cited by 1,520

Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

Mure, L. S., Le, H. D., Benegiamo, G., Chang, M. W., Ríos, L., Jillani, N., Ngotho, M., Kariuki, T., Dkhissi‐Benyahya, O., Cooper, H. M., et al. (2018) · Science · doi:10.1126/science.aao0318 · Cited by 791

Circadian variation in the incidence of sudden cardiac death in the framingham heart study population

Willich, S. N., Levy, D., Rocco, M. B., Tofler, G. H., Stone, P. H., & Muller, J. E. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91027-7 · Cited by 653

Microarray Analysis and Organization of Circadian Gene Expression in Drosophila

McDonald, M. J., & Rosbash, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00545-1 · Cited by 614

Adenosine and Adenosine Receptors in the Cardiovascular System: Biochemistry, Physiology, and Pharmacology

Shryock, J. C., & Belardinelli, L. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00256-7 · Cited by 578

Molecular mechanisms and physiological importance of circadian rhythms

Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,085

Rhythms of life: circadian disruption and brain disorders across the lifespan

Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713

The role of insufficient sleep and circadian misalignment in obesity

Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 733

Genomics of circadian rhythms in health and disease

Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 555

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499

Disturbance of the Circadian System in Shift Work and Its Health Impact

Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 580

Medicine in the Fourth Dimension

Cederroth, C. R., Albrecht, U., Bass, J. T., Brown, S. A., Dyhrfjeld‐Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich‐Förster, C., Hogenesch, J. B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.019 · Cited by 374

Making sense of the ageing methylome

Seale, K., Horvath, S., Teschendorff, A., Eynon, N., & Voisin, S. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00477-6 · Cited by 274

Importance of circadian timing for aging and longevity

Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 258

Dosing time matters

Ruben, M. D., Smith, D. F., FitzGerald, G. A., & Hogenesch, J. B. (2019) · Science · doi:10.1126/science.aax7621 · Cited by 249

Genetics of circadian rhythms and sleep in human health and disease

Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236

Cross-species regulatory sequence activity prediction

Kelley, D. R. (2020) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1008050 · Cited by 228

Metabolic and cardiovascular consequences of shift work: The role of circadian disruption and sleep disturbances

Kervezee, L., Kosmadopoulos, A., & Boivin, D. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14216 · Cited by 232

Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions

Ayyar, V. S., & Sukumaran, S. (2021) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-021-09751-2 · Cited by 228

Circadian disruption, clock genes, and metabolic health

Schrader, L. A., Ronnekleiv‐Kelly, S. M., Hogenesch, J. B., Bradfield, C. A., & Malecki, K. M. C. (2024) · Journal of Clinical Investigation · doi:10.1172/jci170998 · Cited by 229

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target

Bellezza, I. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01280 · Cited by 180

Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans

Talamanca, L., Gobet, C., & Naef, F. (2023) · Science · doi:10.1126/science.add0846 · Cited by 175

Circadian Rhythms, Disease and Chronotherapy

Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 185

Circadian modulation by time-restricted feeding rescues brain pathology and improves memory in mouse models of Alzheimer’s disease

Whittaker, D. S., Akhmetova, L., Carlin, D., Romero, H., Welsh, D. K., Colwell, C. S., & Desplats, P. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.014 · Cited by 147

The liver-clock coordinates rhythmicity of peripheral tissues in response to feeding

Manella, G., Sabath, E., Aviram, R., Dandavate, V., Ezagouri, S., Golik, M., Adamovich, Y., & Asher, G. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00395-7 · Cited by 157

Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space

Kim, Y. H., & Lazar, M. A. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa014 · Cited by 154

Off the Clock: From Circadian Disruption to Metabolic Disease

Maury, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071597 · Cited by 148

The arrival of circadian medicine

Panda, S. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0142-x · Cited by 135

Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review

BaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 144

Genetics of the human circadian clock and sleep homeostat

Ashbrook, L. H., Krystal, A. D., Fu, Y.-H., & Ptáček, L. J. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0476-7 · Cited by 123

Mammalian circadian systems: Organization and modern life challenges

Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117

Origins of human disease: the chrono-epigenetic perspective

Oh, E. S., & Petronis, A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00348-6 · Cited by 108

CosinorPy: a python package for cosinor-based rhythmometry

Moškon, M. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03830-w · Cited by 100

Circadian rhythms and pain

Bumgarner, J. R., Walker, W. H., & Nelson, R. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.004 · Cited by 103

Updates in IDH-Wildtype Glioblastoma

Melhem, J. M., Detsky, J. S., Lim-Fat, M. J., & Perry, J. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01251-6 · Cited by 101

Predicting circadian misalignment with wearable technology: validation of wrist-worn actigraphy and photometry in night shift workers

Cheng, P., Walch, O., Huang, Y., Mayer, C., Sagong, C., Castelan, A. C., Burgess, H. J., Roth, T. G., Forger, D. B., & Drake, C. L. (2020) · SLEEP · doi:10.1093/sleep/zsaa180 · Cited by 90

Circadian rhythms in adaptive immunity

Downton, P. J., Early, J. O., & Gibbs, J. E. (2019) · Immunology · doi:10.1111/imm.13167 · Cited by 87

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

Qu, M., Duffy, T., Hirota, T., & Kay, S. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816411115 · Cited by 85

HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape

Qu, M., Qu, H., Jia, Z., & Kay, S. A. (2021) · Nature Communications · doi:10.1038/s41467-021-26567-3 · Cited by 65

Temozolomide chronotherapy in patients with glioblastoma: a retrospective single-institute study

Damato, A. R., Luo, J. R., Katumba, R. G. N., Talcott, G. R., Rubin, J. B., Herzog, E. D., & Campian, J. L. (2021) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdab041 · Cited by 77

Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle

Lee, Y., Fong, S. Y., Shon, J. H., Zhang, S., Brooks, R. C., Lahens, N. F., Chen, D., Dang, C. V., Field, J. M., & Sehgal, A. (2021) · Science Advances · doi:10.1126/sciadv.abd2645 · Cited by 74

Immunometabolism around the Clock

Carroll, R. G., Timmons, G. A., Cervantes‐Silva, M. P., Kennedy, O. D., & Curtis, A. M. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.013 · Cited by 72

Periodic Parasites and Daily Host Rhythms

Prior, K. F., Rijo‐Ferreira, F., de Assis, P. A., Hirako, I. C., Weaver, D. R., Gazzinelli, R. T., & Reece, S. E. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.01.005 · Cited by 67

Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

Jiang, X., Li, W., Ge, L., & Lü, M. (2023) · Aging and Disease · doi:10.14336/ad.2023.0208 · Cited by 70

Why Lungs Keep Time: Circadian Rhythms and Lung Immunity

Nosal, C. R., Ehlers, A., & Haspel, J. A. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034602 · Cited by 70

Circadian Regulation of Cardiac Physiology: Rhythms That Keep the Heart Beating

Zhang, J., Chatham, J. C., & Young, M. E. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114349 · Cited by 67

Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care

Zhu, X., Maier, G., & Panda, S. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.11.002 · Cited by 58

Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer

Li, S.-Y., Hammarlund, J. A., Wu, G., Lian, J.-W., Howell, S. J., Clarke, R. B., Adamson, A. D., Gonçalves, C. F., Hogenesch, J. B., Anafi, R. C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311854121 · Cited by 58

Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes

Smolensky, M. H., Hermida, R. C., & Geng, Y. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.014 · Cited by 58

The Mammalian Circadian Time-Keeping System

Patton, A. P., & Hastings, M. H. (2023) · Journal of Huntington s Disease · doi:10.3233/jhd-230571 · Cited by 50

A population-based gene expression signature of molecular clock phase from a single epidermal sample

Wu, G., Ruben, M. D., Francey, L. J., Smith, D. F., Sherrill, J. D., Oblong, J. E., Mills, K. J., & Hogenesch, J. B. (2020) · Genome Medicine · doi:10.1186/s13073-020-00768-9 · Cited by 49

Day-night and seasonal variation of human gene expression across tissues

Wucher, V., Sodaei, R., Amador, R., Irimia, M., & Guigó, R. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3001986 · Cited by 51

Ontogeny and function of the circadian clock in intestinal organoids

Rosselot, A. E., Park, M., Kim, M., Matsuura, T., Wu, G., Flôres, D. E. F. L., Subramanian, K. R., Lee, S., Sundaram, N., Broda, T. R., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106973 · Cited by 47

The importance of being rhythmic: Living in harmony with your body clocks

Dibner, C. (2019) · Acta Physiologica · doi:10.1111/apha.13281 · Cited by 52

Solar ultraviolet‐induced DNA damage response: Melanocytes story in transformation to environmental melanomagenesis

Sarkar, S., & Gaddameedhi, S. (2020) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22370 · Cited by 48

The importance of determining circadian parameters in pharmacological studies

Gaspar, L. S., Álvaro, A. R., Carmo‐Silva, S., Mendes, A. F., Relógio, A., & Cavadas, C. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14712 · Cited by 53

TimeTeller for timing health: The potential of circadian medicine to improve performance, prevent disease and optimize treatment

Dose, B., Yalçın, M., Dries, S. P. M., & Relógio, A. (2023) · Frontiers in Digital Health · doi:10.3389/fdgth.2023.1157654 · Cited by 46

Antihypertensive Medication Timing and Cardiovascular Events and Death

Garrison, S., Bakal, J. A., Kolber, M. R., Korownyk, C. S., Green, L. A., Kirkwood, J. E. M., McAlister, F. A., Padwal, R. S., Lewanczuk, R. Z., Hill, M. D., et al. (2025) · JAMA · doi:10.1001/jama.2025.4390 · Cited by 53

Circadian Effects of Drug Responses

Nahmias, Y., & Androulakis, I. P. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-082120-034725 · Cited by 45

Diurnal rhythms across the human dorsal and ventral striatum

Ketchesin, K. D., Zong, W., Hildebrand, M. A., Seney, M. L., Cahill, K. M., Scott, M. R., Shankar, V. G., Glausier, J. R., Lewis, D. A., Tseng, G. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016150118 · Cited by 43

A multi‐level assessment of the bidirectional relationship between aging and the circadian clock

Buijink, M. R., & Michel, S. H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15286 · Cited by 43

Circadian biology to advance therapeutics for mood disorders

Bhatnagar, A., Murray, G., & Ray, S. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.07.008 · Cited by 41

Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans

Thosar, S. S., Rueda, J. F., Berman, A. M., Lasarev, M. R., Herzig, M. X., Clemons, N. A., Roberts, S. A., Bowles, N. P., Emens, J. S., Ellison, D. H., et al. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00314.2018 · Cited by 39

Daytime variation does not impact outcome of cardiac surgery: Results from a diverse, multi-institutional cardiac surgery network

Nemeth, S. K., Schnell, S., Argenziano, M., Ning, Y., & Kurlansky, P. A. (2019) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2019.11.131 · Cited by 39

Sleep Disruption and Bone Health

Swanson, C. M. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00733-y · Cited by 40

Chrono-tailored drug delivery systems: recent advances and future directions

Butler, C. T., Rodgers, A. M., Curtis, A. M., & Donnelly, R. F. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01539-4 · Cited by 42

Systems Level Understanding of Circadian Integration with Cell Physiology

Morris, A. R., Stanton, D., Roman, D., & Liu, A. C. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.02.002 · Cited by 36

Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic

Sengupta, S., Ince, L. M., Sartor, F., Borrmann, H., Zhuang, X., Naik, A. S., Curtis, A. M., & McKeating, J. A. (2021) · Journal of Biological Rhythms · doi:10.1177/0748730420987669 · Cited by 36

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

Xue, X., Zong, W., Glausier, J. R., Kim, S.-M., Shelton, M. A., Phan, B. N., Srinivasan, C., Pfenning, A. R., Tseng, G. C., Lewis, D. A., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01894-1 · Cited by 37

Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses

March, S., Nerurkar, N., Jain, A., Andrus, L., Kim, D. M., Whittaker, C. A., Tan, E. K. W., Thiberge, S., Fleming, H. E., Mâncio-Silva, L., et al. (2024) · Science Advances · doi:10.1126/sciadv.adm9281 · Cited by 36

Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics

Cavieres-Lepe, J., & Ewer, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.666673 · Cited by 40

Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health

Festus, I. D., Spilberg, J., Young, M. E., Cain, S. W., Khoshnevis, S., Smolensky, M. H., Zaheer, F., Descalzi, G., & Martino, T. A. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.011 · Cited by 38

A randomized feasibility study evaluating temozolomide circadian medicine in patients with glioma

Damato, A. R., Katumba, R. G. N., Luo, J. R., Atluri, H., Talcott, G. R., Govindan, A., Slat, E. A., Weilbaecher, K. N., Tao, Y., Huang, J., et al. (2022) · Neuro-Oncology Practice · doi:10.1093/nop/npac003 · Cited by 35

It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.

Kumar, P. V. A., Dakup, P., Sarkar, S., Modasia, J. B., Motzner, M. S., & Gaddameedhi, S. (2019) · PubMed Central · Cited by 34

Circadian misalignment by environmental light/dark shifting causes circadian disruption in colon

Tran, L. B., Jochum, S. B., Shaikh, M. W., Wilber, S., Zhang, L., Hayden, D. M., Forsyth, C. B., Voigt, R. M., Bishehsari, F., Keshavarzian, A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251604 · Cited by 34

Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis

Raza, G. S., Sodum, N., Kaya, Y., & Herzig, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112954 · Cited by 35

Deciphering the relationship between temperature and immunity

Maloney, E., & Duffy, D. (2024) · Discovery Immunology · doi:10.1093/discim/kyae001 · Cited by 38

TimeTeller: A tool to probe the circadian clock as a multigene dynamical system

Vlachou, D. F., Veretennikova, M., Usselmann, L. E. J., Vasilyev, V., Ott, S., Bjarnason, G. A., Dallmann, R., Lévi, F., & Rand, D. A. J. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011779 · Cited by 36

Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications

Ding, H., Meng, L., Liu, A. C., Gumz, M. L., Bryant, A. J., McClung, C. A., Tseng, G. C., Esser, K. A., & Huo, Z. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab224 · Cited by 33

The circadian clock protects against ionizing radiation‐induced cardiotoxicity

Dakup, P., Porter, K. I., Gajula, R. P., Goel, P. N., Cheng, Z., & Gaddameedhi, S. (2020) · The FASEB Journal · doi:10.1096/fj.201901850rr · Cited by 32

Circadian Biology in Obstructive Sleep Apnea

Koritala, B. S. C., Conroy, Z., & Smith, D. F. (2021) · Diagnostics · doi:10.3390/diagnostics11061082 · Cited by 32

Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells

Sarkar, S., Porter, K. I., Dakup, P., Gajula, R. P., Koritala, B. S. C., Hylton, R. K., Kemp, M. G., Wakamatsu, K., & Gaddameedhi, S. (2021) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12998 · Cited by 31

A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

Haspel, J. A., Kim, M., Zee, P. C., Schwarzmeier, T., Montagnese, S., Panda, S., Albani, A., & Merrow, M. W. (2021) · Journal of Biological Rhythms · doi:10.1177/0748730421992587 · Cited by 30

Multi-Modal Regulation of Circadian Physiology by Interactive Features of Biological Clocks

Lee, Y., & Wisor, J. P. (2021) · Biology · doi:10.3390/biology11010021 · Cited by 35

Ingestion-time differences in the pharmacodynamics of hypertension medications: Systematic review of human chronopharmacology trials

Hermida, R. C., Hermida‐Ayala, R. G., Smolensky, M. H., Mojón, A., & Fernández, J. R. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.013 · Cited by 30

Colonic Epithelial Circadian Disruption Worsens Dextran Sulfate Sodium–Induced Colitis

Jochum, S. B., Engen, P. A., Shaikh, M. W., Naqib, A. D., Wilber, S., Raeisi, S., Zhang, L., Song, S., Sanzo, G., Chouhan, V., et al. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac219 · Cited by 33

Circadian disruption and its impact on the cardiovascular system

Young, M. J., Heanue, S., Kanki, M., & Moneghetti, K. J. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.010 · Cited by 32

GDF15: a potential therapeutic target for type 1 diabetes

Sarkar, S., Melchior, J., Henry, H. R., Syed, F., Mirmira, R. G., Nakayasu, E. S., & Metz, T. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2029410 · Cited by 31

CNS Drug Delivery in Stroke: Improving Therapeutic Translation From the Bench to the Bedside

Ronaldson, P. T., Williams, E. I., Betterton, R. D., Stanton, J. A., Nilles, K. L., & Davis, T. P. (2023) · Stroke · doi:10.1161/strokeaha.123.043764 · Cited by 30

Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery

Kim, M., Keep, R. F., & Zhang, S. (2024) · Circulation Research · doi:10.1161/circresaha.123.323521 · Cited by 27

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Li, M., Xin, H., Yuan, Y., Yang, X., Li, H., Tian, D., Zhang, H., Zhang, Z., Han, T.-L., Chen, Q., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.721231 · Cited by 29

Identification of a Preliminary Plasma Metabolome-based Biomarker for Circadian Phase in Humans

Cogswell, D. T., Bisesi, P. J., Markwald, R. R., Cruickshank-Quinn, C. I., Quinn, K. D., McHill, A. W., Melanson, E. L., Reisdorph, N. A., Wright, K. P., & Depner, C. M. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211025402 · Cited by 27

Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression

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