A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine

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TimeTeller: a New Tool for Precision Circadian Medicine and Cancer PrognosisPreprint

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Serum iron and transferrin saturation variation are circadian regulated and linked to the harmonic circadian oscillations of erythropoiesis and hepatic Tfrc expression in mice

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A synthetic chronogenetic gene circuit for programmed circadian drug delivery

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Tuning up an aged clock: Circadian clock regulation in metabolism and aging

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Circadian regulation of microglia function: Potential targets for treatment of Parkinson’s Disease

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Time-restricted eating, the clock ticking behind the scenes

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Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model

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Disruption of day‐to‐night changes in circadian gene expression with chronic tendinopathy

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Experimental design and power calculation in omics circadian rhythmicity detection using the cosinor model

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Circadian Regulation of the Neuroimmune Environment Across the Lifespan: From Brain Development to Aging

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Daily Time of Radiation Treatment Is Associated with Subsequent Oral Mucositis Severity during Radiotherapy in Head and Neck Cancer Patients

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Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts

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Diurnal and circadian rhythmicity of the human blood transcriptome overlaps with organ- and tissue-specific expression of a non-human primate

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Effect of the Citrus Flavone Nobiletin on Circadian Rhythms and Metabolic Syndrome

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Circadian medicine for aging attenuation and sleep disorders: Prospects and challenges

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Cardiomyocyte transcription is controlled by combined mineralocorticoid receptor and circadian clock signalling

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Data integration and analysis for circadian medicine

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Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism

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Circadian protein expression patterns in healthy young adults

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Interplay between circadian rhythm, ageing and neurodegenerative disorder

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CircadiOmic medicine and aging

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Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations

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Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice

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Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects

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Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions

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Gene networks under circadian control exhibit diurnal organization in primate organs

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The molecular circadian rhythms regulating the cell cycle

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Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption

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Enhanced Circadian Clock in MSCs-Based Cytotherapy Ameliorates Age-Related Temporomandibular Joint Condyle Degeneration

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Integration of genome-scale data identifies candidate sleep regulators

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Time-of-day-dependent variation of the human liver transcriptome and metabolome is disrupted in MASLD

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Sleep and Circadian Medicine

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Diurnal Variation of Plasma Extracellular Vesicle Is Disrupted in People Living with HIV

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Small Intestinal Microbiota Oscillations, Host Effects and Regulation—A Zoom into Three Key Effector Molecules

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Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery

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Pharmacokinetics-based Chronotherapy

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SRTdb: an omnibus for human tissue and cancer-specific RNA transcripts

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Cellular clocks in hyperoxia effects on [Ca2+]i regulation in developing human airway smooth muscle

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Organoids as Model Systems to Investigate Circadian Clock-Related Diseases and Treatments

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One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike

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How to tell time: advances in decoding circadian phase from omics snapshots

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Chronotype distribution in the Chinese population

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Metabolic Homeostasis: It’s All in the Timing

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An in silico genome-wide screen for circadian clock strength in human samples

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Estimation of bloodstain deposition time within a 24-h day-night cycle with rhythmic mRNA based on a machine learning algorithm

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Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment

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Sex Inclusion in Transcriptome Studies of Daily Rhythms

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Single-cell transcriptomics allows novel insights into aging and circadian processes

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DAILY—A Personalized Circadian Zeitgeber Therapy as an Adjunctive Treatment for Alcohol Use Disorder Patients: Study Protocol for a Randomized Controlled Trial

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Chronopharmacokinetics and Food Effects of Single-Dose LCP-Tacrolimus in Healthy Volunteers

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The chronobiology of human heart failure: clinical implications and therapeutic opportunities

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It’s about time: circadian medicine in the intensive care unit

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Mathematical modeling of mammalian circadian clocks affecting drug and disease responses

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Analysis of Diurnal Variations in Heart Rate: Potential Applications for Chronobiology and Cardiovascular Medicine

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LimoRhyde2: Genomic analysis of biological rhythms based on effect sizes

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CIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans

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Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation

Lim, R., Chae, J., Somers, D. E., Ghim, C.-M., & Kim, P. (2021) · iScience · doi:10.1016/j.isci.2021.102726 · Cited by 8

Diurnal Variation in Trigeminal Pain Sensitivity in Mice

Niiro, A., Ohno, S. N., Yamagata, K. A., Yamagata, K., Tomita, K., Kuramoto, E., Oda, Y., Nakamura, T. J., Nakamura, W., & Sugimura, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.703440 · Cited by 8

A single factor dominates the behavior of rhythmic genes in mouse organs

Yang, C., Chi, Y., Zhang, L., & Wang, G. (2019) · BMC Genomics · doi:10.1186/s12864-019-6255-3 · Cited by 8

Letter to the Editor: Sleep Disturbances in Selective Serotonin Reuptake Inhibitor-Treated Youth with Anxiety Disorders and Obsessive Compulsive Disorder—A Bayesian Hierarchical Modeling Meta-Analysis

Skoch, S. H., Mills, J. A., Ramsey, L. B., & Strawn, J. R. (2021) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2020.0169 · Cited by 8

Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo

Ananthasubramaniam, B., & Venkataramanan, R. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003196 · Cited by 9

Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism

Zhou, D., Chen, Y., Liu, P., Zhu, K., Holder-Haynes, J. G., Lloyd, S. J.-A., La, C. M., Astapova, I. I., Choa, S., Xiong, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.010 · Cited by 7

Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

Zhao, H., Liao, M., Huo, R., He, T., Tian, H., Li, Z., Chen, C., Yu, Z., Chai, J., Song, X., et al. (2026) · Cell · doi:10.1016/j.cell.2026.01.016 · Cited by 8

Molecular components of the circadian clock regulate HIV-1 replication

Borrmann, H., Ulkar, G., Kliszczak, A. E., Ismed, D., Schilling, M., Magri, A., Harris, J. M., Balfe, P., Vasudevan, S. R., Borrow, P., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107007 · Cited by 9

A comprehensive rhythmicity analysis of host proteins and immune factors involved in malaria pathogenesis to decipher the importance of host circadian clock in malaria

Rankawat, S., Kundal, K., Chakraborty, S., Kumar, R., & Ray, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1210299 · Cited by 7

Chronodisruption that dampens output of the central clock abolishes rhythms in metabolome profiles and elevates acylcarnitine levels in the liver of female rats

Arora, S., Houdek, P., Čajka, T., Dočkal, T., Sládek, M., & Sumová, A. (2025) · Acta Physiologica · doi:10.1111/apha.14278 · Cited by 6

Utility of Circadian Variability Patterns in Differentiating Origins of Premature Ventricular Complexes

Chen, M., Wang, Q., Sun, J., Zhang, P., Li, W., Zhang, R., Mo, B., Chen, T.-Z., Wan, J., Xu, D., et al. (2020) · Journal of Interventional Cardiology · doi:10.1155/2020/7417912 · Cited by 8

Manifold medicine: A schema that expands treatment dimensionality

Ung, C. Y., Weisskittel, T., Correia, C., Kaufmann, S. H., & Li, H. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.09.016 · Cited by 7

The circadian clock ticks in organoids

Yamada, R. G., & Ueda, H. R. (2021) · The EMBO Journal · doi:10.15252/embj.2021110157 · Cited by 7

Isoform-specific regulation of rhythmic gene expression by alternative polyadenylationPreprint

Greenwell, B. J., Beytebiere, J. R., Lamb, T. M., Bell‐Pedersen, D., Merlin, C., & Menet, J. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.12.422514 · Cited by 5

Targeting the circadian modulation: novel therapeutic approaches in the management of ASD

Zhang, Y., Chen, Y. J., Li, W., Tang, L., Li, J., & Feng, X. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1451242 · Cited by 7

Circadian Biology in Obstructive Sleep Apnea-Associated Cardiovascular Disease

Gaspar, L. S., Pyakurel, S., Xu, N., D’Souza, S. P., & Koritala, B. S. C. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.03.008 · Cited by 5

Time matters: circadian genetics and the molecular logic of human health and disease

Kuo, T. T., Wang, J., & Kay, S. A. (2026) · Nature Reviews Genetics · doi:10.1038/s41576-026-00962-2 · Cited by 8

Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems

Heywood, H. K., Gardner, L., Knight, M. M., & Lee, D. A. (2022) · In vitro models · doi:10.1007/s44164-022-00032-x · Cited by 7

Modern immunology is crucial to revealing the biological mechanisms of traditional Chinese medicine

Ju, L., Jiang, J., Jin, Y., Armand, J., & Charron, D. J. (2023) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2023.10.001 · Cited by 6

Integrated bioinformatics and interaction analysis to advance chronotherapies for mental disorders

Bhatnagar, A., Raj, G., Das, S., Kannihalli, A., Rajakumara, E., Murray, G., & Ray, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1444342 · Cited by 7

A Characteristic Expression Pattern of Core Circadian Genes in the Diurnal Tree Shrew

Luo, P.-H., Shu, Y., Ni, R., Liu, Y.-J., & Zhou, J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.04.027 · Cited by 6

Time Matters: Importance of Circadian Rhythms, Disruption, and Chronotherapy in Urologic Malignancies

Pence, S. T., Chesnut, G. T., & Shafi, A. A. (2023) · Urology · doi:10.1016/j.urology.2023.01.009 · Cited by 6

Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19

Hashikawa, K.-I., Tsuruta, A., Yamakawa, W., Yasukochi, S., Koyanagi, S., & Ohdo, S. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.070 · Cited by 6

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

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Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks

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El reloj intracelular

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