An ocular glymphatic clearance system removes β-amyloid from the rodent eye

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413

The Pathophysiology and Treatment of Glaucoma: A Review

Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198

Detecting outliers when fitting data with nonlinear regression – a new method based on robust nonlinear regression and the false discovery rate

Motulsky, H. J., & Brown, R. E. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-123 · Cited by 1,616

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565

Relationship Between Intraocular Pressure and Primary Open Angle Glaucoma Among White and Black Americans

Sommer, A. H. (1991) · Archives of Ophthalmology · doi:10.1001/archopht.1991.01080080050026 · Cited by 1,178

The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage

Burgoyne, C. F., Downs, J. C., Bellezza, A. J., Suh, J.-K. F., & Hart, R. T. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.001 · Cited by 1,142

Decoding amyloid beta clearance systems at inner blood–retina barrier using three‐dimensional ex vivo retinal imaging in Alzheimer's disease

Wijesinghe, P., Hosseini, A., Campbell, M., Tejpal, S., Haynes, J. R., Xi, J., Mackenzie, I. R., Hirsch‐Reinshagen, V., Hsiung, G. R., Spiller, B. W., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70592 · Cited by 7

Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model

Bergen, T. V., Hu, T., Little, K., Groef, L. D., Moons, L., Stitt, A. W., Vermassen, E., & Feyen, J. H. M. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.13.18 · Cited by 9

A mammal and bird's‐eye‐view of the pupil during sleep and wakefulness

Ungurean, G., & Rattenborg, N. C. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15983 · Cited by 8

Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study

Zhou, W., Yang, J., Wang, Q., Wang, Y. X., Yan, Y., Wu, S., Chen, S., & Wei, W. (2021) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.62.2.20 · Cited by 10

Glymphatics: A Transformative Development in Medical Neuroscience Relevant to Injuries in Military Central Nervous System

Meyerhoff, J. L., Chakraborty, N., & Hammamieh, R. (2021) · Military Medicine · doi:10.1093/milmed/usab344 · Cited by 9

The “ocular glymphatic clearance system”: a key missing piece of the Alzheimer’s disease-glaucoma puzzle found?

Wostyn, P. (2020) · Eye · doi:10.1038/s41433-020-1008-8 · Cited by 9

New Perspective on Aqueous Humor Circulation: Retina Takes the Lead

Ueki, S., & Suzuki, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062645 · Cited by 8

Retinal manifestations and their diagnostic significance in Alzheimer's disease

Abhyankar, S. D., Little, K., Stitt, A. W., & Bhatwadekar, A. D. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251361937 · Cited by 8

Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI

van der Thiel, M. M., van de Sande, N., Meeusen, A., Drenthen, G. S., Postma, A. A., Nuijts, R. M. M. A., van der Knaap, N., Ramakers, I. H. G. B., Webers, C. A. B., Backes, W. H., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106730 · Cited by 8

Fluid transport from the dental pulp revisited

Berggreen, E., Wiig, H., & Virtej, A. (2020) · European Journal Of Oral Sciences · doi:10.1111/eos.12733 · Cited by 8

Sleep and optic disc edema in spaceflight associated neuro-ocular syndrome (SANS)

Nguyen, T. N., Ong, J., Waisberg, E., & Lee, A. G. (2024) · Eye · doi:10.1038/s41433-024-03119-9 · Cited by 8

Correspondence

Wostyn, P., Gibson, C. R., & Mader, T. H. (2020) · Retina · doi:10.1097/iae.0000000000003068 · Cited by 8

Spaceflight associated neuro-ocular syndrome: connections with terrestrial eye and brain disorders

Joe, B. (2024) · Frontiers in Ophthalmology · doi:10.3389/fopht.2024.1487992 · Cited by 7

Evaluation of the Glymphatic System in Rabbits Using Gadobutrol‐Enhanced MR Cisternography With T1 and T2 Mapping

Algın, O., Çetinkaya, K., Oto, Ç., & Ayberk, G. (2024) · NMR in Biomedicine · doi:10.1002/nbm.5314 · Cited by 7

Mathematical modelling of the CSF system: effects of microstructures and posture on optic nerve subarachnoid space dynamics

Holmlund, P., Støverud, K.-H., & Eklund, A. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00366-4 · Cited by 7

Advances in the Understanding of ocular and nasal lymphatics

Yan, M., Cheng, L., Zheng, Z., Lin, Y., Qin, D., & Chen, H. (2025) · BMC Immunology · doi:10.1186/s12865-025-00697-5 · Cited by 7

[64Cu]Cu-Albumin Clearance Imaging to Evaluate Lymphatic Efflux of Cerebrospinal Space Fluid in Mouse Model

Sarker, A. K., Suh, M., Choi, Y., Park, J. Y., Kwon, S., Kim, H., Lee, E. J., Seo, H., Lee, Y., & Lee, D. S. (2022) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-022-00746-6 · Cited by 6

Pathophysiology of cerebral edema and its connection to Spaceflight Associated Neuro-Ocular Syndrome

Galdamez, L. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91524-3.00002-8 · Cited by 7

Perivascular pumping in the mouse brain: Realistic boundary conditions reconcile theory, simulation, and experimentPreprint

Ladrón-de-Guevara, A., Shang, J., Nedergaard, M., & Kelley, D. H. (2020) · bioRxiv · doi:10.1101/2020.07.02.183608 · Cited by 8

Pericytes in the optic nerve head

Waxman, S., Villafranca‐Baughman, D., Phillippi, J. A., Jakobs, T., Alarcón-Martínez, L., Polo, A. D., & Sigal, I. A. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101375 · Cited by 6

Integrated analysis of in vivo retinal perivascular amyloid imaging and cognition

Gonzales, M. M., Fuchs, D.-T. S., Doustar, J., Koronyo, Y., Sherman, D. S., Lyden, P. D., Sicotte, N. L., Black, K. L., Kremen, S. A., Dumitrascu, O. M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70366 · Cited by 6

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies

Ward, E., Benowitz, L. I., Brunner, T. M., Bu, G., Cayouette, M., Canto-Soler, V., Mesquita, S. D., Polo, A. D., DiAntonio, A., Duan, X., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00858-5 · Cited by 7

Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687

Vanhove, M., Wagner, J.-M., Noppen, B., Jonckx, B., Vermassen, E., & Stitt, A. W. (2021) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-021-09774-9 · Cited by 6

Sleep, glymphatic system, and Parkinson’s disease

Wang, Y., Zou, W., Jin, Z., Yin, S., Chi, X., Li, J., Sun, Y., Wu, J., Kou, L., Xia, Y. F., et al. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2023.56 · Cited by 7

Preclinical characterization of endotoxin-induced uveitis models using OCT, PET/CT and proteomics

Cuartero‐Martínez, A., García‐Otero, X., Codesido, J., Gómez‐Lado, N., Mateos, J., Bravo, S. B., Rodríguez-Fernández, C. A., González‐Barcia, M., Aguiar, P., Ortega, M., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124516 · Cited by 6

Light-sensitive Ca 2+ signaling in the mammalian choroid

Eltanahy, A. M., Aupetit, A., Buhr, E. D., Gelder, R. N. V., & Gonzales, A. L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2418429121 · Cited by 6

Glymphatic system impairment in normal tension glaucoma evaluated by diffusion tensor image analysis along the perivascular space

Li, T., Wang, Q., Yang, B. T., Qu, X., Chen, W., Wang, H., Wang, N., & Xian, J. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149450 · Cited by 7

Carbohydrate Polymers, Polymeric Nano Drugs, and Nanoparticles Are Used for Advanced Drug Delivery and Therapeutics in Ocular Diseases

Hatamie, S., Shih, P., Chen, B., & Hatami, N. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70094 · Cited by 7

Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders

Chen, F., Xie, X., & Wang, L. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.865714 · Cited by 6

Microgravity and Lymphatics: Why Space Programs Need Lymphedema Physiology Specialists

Hettrick, H., & Aviles, F. (2023) · Lymphatic Research and Biology · doi:10.1089/lrb.2022.0070 · Cited by 6

Ocular Solute Movement Direction and Intracranial Clearance via Vitreous Gadolinium-based Contrast Agent MR Imaging: Potential as a Novel Biomarker for Glymphatic Dysfunction

Naganawa, S., Ito, R., Kawamura, M., Taoka, T., Yoshida, T., & Sone, M. (2025) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.mp.2025-0127 · Cited by 5

Advances in eye-brain axis: Anatomy, immunity, and association with visual dysfunction

Zhang, S., Fan, Z., & Ji, D. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102925 · Cited by 5

Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging

Naganawa, S., Ito, R., Kawamura, M., Taoka, T., Yoshida, T., & Sone, M. (2024) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.mp.2024-0011 · Cited by 5

Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina

Carrero, L., Antequera, D., Alcalde, I., Megı́as, D., Ordóñez‐Gutiérrez, L., Gutiérrez, C., Merayo-Llovés, J., Wandosell, F. G., Municio, C., & Carro, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115679 · Cited by 5

Association of optic disc pallor and RNFL thickness with cerebral small vessel disease in the PREVENT‐Dementia study

Gibbon, S., Low, A., Hamid, C., Reid‐Schachter, M., Terrera, G. M., Ritchie, C. W., Trucco, E., Dhillon, B., O'Brien, J. T., & MacGillivray, T. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12633 · Cited by 5

Terson Syndrome: A Review of the Literature

Stevanovic, M., & Eliott, D. (2024) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000502 · Cited by 4

Spatiotemporal Immune Dynamics in Experimental Retinal Ganglion Cell Injury Models

Yang, C., Wang, X., Ye, X., Shen, Y., Tong, J., Zhang, X., & Zhou, Y. (2025) · Immunity Inflammation and Disease · doi:10.1002/iid3.70284 · Cited by 4

Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms

Ebrahimi, S.-M., Tuunanen, J., Saarela, V. O., Honkamo, M., Huotari, N., Raitamaa, L., Korhonen, V. O., Helakari, H., Järvelä, M., Kaakinen, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-51069-1 · Cited by 4

The Enigma of the Posterior Displacement of the Bruch Membrane Opening During Spaceflight

Wostyn, P., Gibson, C. R., & Mader, T. H. (2022) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2022.3637 · Cited by 4

Myelinosome organelles in pathological retinas: ubiquitous presence and dual role in ocular proteostasis maintenance

Yéfimova, M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.355753 · Cited by 4

Protein Drug Delivery Using a Novel Maxillofacial Technique Targeting the Visual Pathway in the Brain, the Optic Nerve, and the Retina

Rajendran, R., Arunachalam, J. P., Chidambaram, S., Srikanth, K., Krishnamurthy, B., Vinayagam, S., Veeravarmal, V., Prasad, H., Verma, K., & Anoop, U. R. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00184 · Cited by 4

Acute use of lower body negative pressure during spaceflight does not decrease choroidal thickness

Wostyn, P., Gibson, C. R., & Mader, T. H. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00600.2021 · Cited by 4

Mechanisms Involved in Cerebrospinal Fluid (CSF) Drainage and Interstitial Fluid (ISF)/CSF Exchange in the Central Nervous System (CNS)

Esmaeli, M. (2025) · Cell and Tissue Biology · doi:10.1134/s1990519x24600637 · Cited by 3

Unveiling potential retinal and choroidal markers with SS-OCTA in detecting cerebral small vessel disease

Shen, Z., Yu, W., Gao, S., Zhang, S., & Hong, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-21628-9 · Cited by 3

Optic nerve glymphatic system: Physiological characterization, ischemia-induced changes, and neuroprotection in ischemic optic neuropathy

Zhang, Y., Chen, Z., Jiang, Y., Ye, Q., Lin, J., Zhang, X., Li, D., Hu, Q., Fu, Y., Liu, L., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107214 · Cited by 3

Macrophage-mediated refinement of the dural lymphatic regulates social behavior

Tavares, G. A., O’Reilly, L., Frederick, N. M., Shapiro, D. A., Vicchiarelli, A., Sullivan, M., Jiang, N., Mattes, M., Goelz, C., Uchegbu, N., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.03.019 · Cited by 4

The Glymphatic System in Idiopathic Intracranial Hypertension

Bouffard, M. A., Ford, J. N., & Grech, O. (2026) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000002483 · Cited by 3

Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival

Fernández‐Albarral, J. A., Simón‐García, A., Salobrar‐García, E., Salazar, J. J., López‐Menéndez, C., Pajuelo, L. S. M., Matamoros, J. A., de Hoz, R., López‐Cuenca, I., Elvira‐Hurtado, L., et al. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00626-z · Cited by 3

Age-Related Macular Degeneration and Circadian Preference

Garces-Delgado, E., Slota, K. A., Stewart, M., García-Guzmán, M., Werninck, N., & Castillo, P. R. (2025) · Clinical ophthalmology · doi:10.2147/opth.s487389 · Cited by 3

Objective test findings in patients with chronic eye symptoms seeking care at an outpatient neck center: ligamentous cervical instability etiology?

Hauser, R. A., Griffiths, M., Watterson, A., Matias, D. P., & Rawlings, B. R. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1576315 · Cited by 3

Cerebrospinal fluid and ophthalmic disease

Ford, R. L., Frankfort, B. J., & Fleischman, D. (2021) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000818 · Cited by 5

A new look at ocular glymphatic transport in space

Wostyn, P., & Nedergaard, M. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00169.2024 · Cited by 3

The optic nerve in spaceflight: novel concepts in the pathogenesis of optic disc edema in microgravity

Kadipasaoglu, C. M., Lee, V. A., Ong, J., & Lee, A. G. (2024) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001334 · Cited by 3

The Lack of Amyloidogenic Activity Is Persistent in Old WT and APPswe/PS1ΔE9 Mouse Retinae

Joly, S., Rodriguez, L., & Pernet, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111344 · Cited by 2

Association of circadian dysregulation with retinal degeneration and Alzheimer’s disease: a special focus on Muller glial cells

Das, G., & Milner, T. E. (2024) · Frontiers in Photonics · doi:10.3389/fphot.2024.1389683 · Cited by 2

Should poor sleep be added to the list of risk factors for normal-tension glaucoma in the future?

Wostyn, P., & Nedergaard, M. (2025) · Eye · doi:10.1038/s41433-025-03748-8 · Cited by 2

SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY IMAGING OF THE OPTIC PIT COMPLEX

Spaide, R. F. (2025) · Retina · doi:10.1097/iae.0000000000004662 · Cited by 2

Diffusion tensor imaging along the perivascular space may reveal potential pathological mechanisms underlying disease progression in primary open-angle glaucoma patients

Chen, Y., Xiao, S., Yan, L., Gong, Z., Huang, Y., Tan, W., & Ying, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1659200 · Cited by 2

Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients

Bang, J. W., Parra, C., Yu, K., Lee, H. S., Wollstein, G., Schuman, J. S., & Chan, K. C. (2026) · npj Aging · doi:10.1038/s41514-025-00315-z · Cited by 4

Intranasal Approach of Thermoresponsive Hydrogel Delivering Dexamethasone to the Inner Ear for Treating Hearing Loss

Ding, Y., Zhang, D., Li, J., Xu, L., & Wang, H. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c25187 · Cited by 2

Loss of Pericyte Exacerbates Alzheimer's Disease‐Associated Retinal Pathology

Hai‐Chao, C., Fu‐Lin, G., Jia‐Xin, C., Yi‐Shu, Z., Lei, W., & Jing, Y. (2026) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.70103 · Cited by 2

Ocular Glymphatic System: Its Modulation and Role in Intraocular Tumors

Francis, J. H., & Abramson, D. H. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.4.11 · Cited by 2

Age-Related Neurovascular Dysfunction in the Retina and Potential Pathogenic Mechanisms

Wu, Y., Cao, Q., & Liu, Q. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.4.16 · Cited by 2

New insights in brain-to-eye transport: can excess cerebrospinal fluid in astronauts escape into the eye?

Wostyn, P., Mader, T. H., Gibson, C. R., & Nedergaard, M. (2024) · Eye · doi:10.1038/s41433-024-03430-5 · Cited by 2

Could Sleep Be an Antidote to Optic Disc Edema in Astronauts?

Wostyn, P., & Nedergaard, M. (2025) · Life · doi:10.3390/life15020183 · Cited by 2

Gadolinium-Based Imaging and the Study of Neurofluid Dynamics

Ringstad, G. A., Eide, P. K., Naganawa, S., & Agarwal, N. (2025) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2024.12.008 · Cited by 3

Choroid plexus asymmetry predicts decline in fundus blood flow in white matter hyperintensity patients: insights from SS-OCTA

Shen, Z., Yu, W., Ye, J., Gao, S., Zheng, J., Yu, L., Gao, F., Hong, C., & Zhang, S. (2025) · Therapeutic Advances in Ophthalmology · doi:10.1177/25158414251359581 · Cited by 2

Clinical review of retinotopy

Bijvank, J. N., Wenniger, L. J. M. D. B., de Graaf, P., & Petzold, A. (2021) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2021-320563 · Cited by 2

Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome

Wostyn, P., & Nedergaard, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91524-3.00016-8 · Cited by 2

Optic nerve head: A gatekeeper for vitreous infectious insults?

Lai, W., Huang, J., Fang, W., Deng, S., Xie, Y., Wang, W., Qiao, T., Xu, G., Wang, X., & Ding, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.987771 · Cited by 3

The relationship between open angle glaucoma, optic disc morphology and Alzheimer’s Disease: a Mendelian randomization studyPreprint

Budu‐Aggrey, A., Hysi, P. G., Kehoe, P. G., Igo, R. P., Wiggs, J. L., Bailey, J. N. C., Haines, J. L., Pasquale, L. R., MacGregor, S., Biobank, U., et al. (2020) · medRxiv · doi:10.1101/2020.08.30.20184846 · Cited by 2

Peripapillary Hyper‐Reflective Ovoid Mass‐Like Structures in Astronauts

Wostyn, P., Gibson, C. R., & Mader, T. H. (2021) · Annals of Neurology · doi:10.1002/ana.26027 · Cited by 2

From hearing loss to neurological complications: Is there an “ear glymphatic system”?

Bi, Y., Yang, Y.-C., Zhang, G., Wang, H., & Dong, R. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14846 · Cited by 2

Investigating Optic Nerve Sheath Diameter in Prone Position Spinal Surgery Patients: A Pilot Study

Rahangdale, A., Fernandez, E., Weinberg, D. S., & Fleischman, D. (2024) · Journal of Ophthalmic and Vision Research · doi:10.18502/jovr.v19i3.13863 · Cited by 1

Cortical Morphology Alterations Mediate the Relationship Between Glymphatic System Function and the Severity of Asthenopia

Chen, Y., Xu, J., Kong, Y., Kang, Y., Gong, Z., Wang, H., Huang, Y., Zhan, S., Yu, Y., Lv, X., et al. (2025) · International Journal of Biomedical Imaging · doi:10.1155/ijbi/4464776 · Cited by 1

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Ebrahimi, S.-M., Huotari, N., Saarela, V. O., Honkamo, M., Raitamaa, L., Korhonen, V. O., Tuunanen, J., Kananen, J., & Kiviniemi, V. J. (2025) · Acta Ophthalmologica · doi:10.1111/aos.17510 · Cited by 1

The brain-eye-liver axis during spaceflight: implications of hepatic dysfunction in spaceflight associated neuro-ocular syndrome

Helvacıoğlu, S., Cools, B., Ong, J., Waisberg, E., Lee, R. S., Lee, A. G., & Vinken, M. (2025) · Life Sciences in Space Research · doi:10.1016/j.lssr.2025.07.001 · Cited by 1

Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems

Wang, Y., Guo, P., Li, W., & Li, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1595275 · Cited by 1

Blood Labyrinth Barrier Waste Clearance as Assessed by GBCAs on MRI : A Scoping Review

Ahmad, S. A., Huang, E. Y., Kim, J. S., Balhi, Y., Spann, M., & Ward, B. K. (2025) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.70240 · Cited by 1

Cervical Oculopathy: The Cervical Spine Etiology of Visual Symptoms and Eye Diseases—A Hypothesis Exploring Mechanisms Linking the Neck and the Eye

Hauser, R. A., Griffiths, M., Matias, D. P., & Rawlings, B. R. (2025) · Diagnostics · doi:10.3390/diagnostics15202650 · Cited by 1

Glymphatic Dysfunction Coupled with Altered Neural Activity in High Myopia: Multimodal Study of Brain−Eye Interactions

Zhang, X., Liu, L., Han, S., Jin, X., Pan, X., Zhang, Y., Cheng, J., Zhang, B., & Wen, B. (2026) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.70200 · Cited by 1

Ocular Glymphatic Dysfunction as a Potential Link Between Obstructive Sleep Apnea and Retinal Structural Changes. Comment on Pusic Sesar et al. Multimodal Assessment of Ocular Parameters in Patients with Severe Obstructive Sleep Apnea with Emphasis on Retinal Structural Changes. Life 2025, 15, 1307

Wostyn, P., & Nedergaard, M. (2026) · Life · doi:10.3390/life16020214 · Cited by 1

The Ocular Glymphatic System: Current Evidence and Emerging Hypotheses

Magonio, F. (2026) · Journal of Ophthalmology and Advance Research · doi:10.46889/joar.2026.7116

Targeting the brain: alternative administration routes and drug delivery systems for antidepressant therapy

Figueiredo, I., Bicker, J., Vitorino, C., & Fortuna, A. C. (2026) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2026.2668677 · Cited by 2

Biomaterial-based ocular drug delivery: strategies, challenges, and future perspectives

Chen, Y., Yang, J., Zhou, K., Chen, Z., & Zhang, J. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116377 · Cited by 1

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Alemán-Villa, K. M., Terán, E., Magaña‐Gómez, J. A., Calderón-Zamora, L., la Herrán-Arita, B. K. D., & la Herrán-Arita, A. K. D. (2026) · Sensory Neuroscience · doi:10.1002/sen2.70039 · Cited by 1

Hydrostatic Pressure Gradients and a New Membrane-glymphatic Theory of Primary Glaucoma

Beisekeeva, J., Kulumbetova, J., Beisekeev, S., & Кочергин, С. А. (2022) · International Journal of Ophthalmology & Visual Science · doi:10.11648/j.ijovs.20220701.13 · Cited by 1

Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study

Kaçar, S., Coric, D., Ometto, G., Montesano, G., Denniston, A. K., Keane, P. A., Uitdehaag, B. M. J., Crabb, D. P., Schoonheim, M. M., Petzold, A., et al. (2023) · Brain Sciences · doi:10.3390/brainsci14010036 · Cited by 1

An immunological window to the brain

Walsh, J. T., & Kipnis, J. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00457-5 · Cited by 1

The potential influence of sleep on translaminar pressure dynamics and ocular glymphatic outflow in microgravity: implications for optic disc edema in astronauts

Wostyn, P., & Nedergaard, M. (2024) · Eye · doi:10.1038/s41433-024-03269-w · Cited by 1

Changes in Adsorption, Aggregation, and Diffusion Nature of Amyloid β on a Lipid Membrane in an Open System

Iida-Adachi, A., & Nabika, H. (2025) · Langmuir · doi:10.1021/acs.langmuir.4c03663 · Cited by 1

Dual-pressure theory: new developments and future directions

Cheng, Y., & Wang, N. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3013-9 · Cited by 1

Assessment of the DTI ‐ ALPS Index in Adolescents With Sport‐Related Concussion

Castro, E. V., Chizuk, H. M., Bergsland, N., Dwyer, M. G., Muldoon, S. F., Schweser, F., Leddy, J. J., & Haider, M. N. (2025) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.70073 · Cited by 1

Re: Wåhlin et al.: Optic nerve length before and after spaceflight (Ophthalmology. 2021;128:309–316)

Wostyn, P., Gibson, C. R., & Mader, T. H. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2021.01.003 · Cited by 1

Ocular Lymphatics and Lymphangiogenesis

Chen, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13820-1.00160-2 · Cited by 1

Reply

Spaide, R. F. (2020) · Retina · doi:10.1097/iae.0000000000003069

1051 透水性型枠を使用したコンクリートの性能改善(強度・力学的性質)

三島, 直., 畑中, 重., 小林, 広., & 犬飼, 利. (2004) · コンクリート工学年次論文集

Reply

Wåhlin, A., Holmlund, P., Fellows, A. M., Malm, J., Buckey, J. C., & Eklund, A. (2021) · Ophthalmology · doi:10.1016/j.ophtha.2021.01.004

Pulpa og væskedrenasje. Hva vet vi nå og hva kan det bety i klinikken?

Berggreen, E., & Virtej, A. (2021) · Den norske tannlegeforenings Tidende · doi:10.56373/2021-9-3

Intrathecal [ 64 Cu]Cu-albumin PET reveals age-related decline of cerebrospinal fluid (CSF)-lymphatic effluxPreprint

Sarker, A. K., Suh, M., Choi, Y., Park, J. Y., Lee, Y., & Lee, D. S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.18.524645

The Ocular Glymphatic Clearance SystemPreprint

Wang, X., Lou, N., Eberhardt, A., Kusk, P., Xu, Q., Förstera, B., Peng, S., Yang, Y., Shi, M., Xavier, A. L. R., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.29.889873

Do normal-tension and high-tension glaucoma result from brain and ocular glymphatic system disturbances, respectively?

Wostyn, P. (2020) · Eye · doi:10.1038/s41433-020-01219-w · Cited by 21

The “ocular glymphatic clearance system”: a key missing piece of the Alzheimer’s disease-glaucoma puzzle found?

Wostyn, P. (2020) · Eye · doi:10.1038/s41433-020-1008-8 · Cited by 9

Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma

Thrane, V. R., Hynnekleiv, L., Wang, X., Thrane, A. S., Krohn, J., & Nedergaard, M. (2020) · Acta Ophthalmologica · doi:10.1111/aos.14524 · Cited by 25

Research Progress of Ocular Glymphatic System and Related Ocular Diseases

ZHU Guangyu, C. Y. (2023) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.12114/j.issn.1007-9572.2022.0901