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Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
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Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption.
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“Only the deletion of both MMP9 and MMP14 generated a reduction in bone resorption areas and in type I collagenolysis activity.153”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [153]
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Metadata
- Authors
- Zhu, L., Tang, Y., Li, X.-Y., Keller, E. T., Yang, J., Cho, J.-S., Feinberg, T. Y., & Weiss, S. J.
- Affiliations
- University of Michigan (US)
- Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
- Corresponding author
- Zhu, Lingxin
- Weiss, Stephen J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-02-05
- Volume
- 12
- Issue
- 529
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7603424
- OpenAlex
- W3005525925
- Cited by
- 178
- References
- 89
- Citations by year
- 2026: 30 · 2025: 31 · 2024: 34 · 2023: 25 · 2022: 24 · 2021: 18 · 2020: 15
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AI105068, CA093900, CA071699, AR075168)
- Breast Cancer Research Foundation
- National Natural Science Foundation of China (81970919)
- Margolies Family Discovery Fund for Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclasts, bone resorption, metalloproteinases, MMP-9, MMP-14, collagen degradation, bone mineral density, parathyroid hormone, ovariectomy, bone loss, therapeutic target
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Cathepsins, Female, Humans, Osteoclasts, Osteoporosis, Ovariectomy, Mice
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