Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

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Statins Exert Endothelial Atheroprotective Effects via the KLF2 Transcription Factor

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Lamins at the crossroads of mechanosignalingPreprint

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Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

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Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer

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Lamins at a glance

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Lamin A/C-promoter interactions specify chromatin state–dependent transcription outcomesPreprint

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Transdifferentiation of Human Fibroblasts to Endothelial Cells

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Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

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Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A/C gene mutations

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Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

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Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

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Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease

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Premature Atherosclerosis Associated With Monogenic Insulin Resistance

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Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

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Determining the Pathogenicity of a Genomic Variant of Uncertain Significance Using CRISPR/Cas9 and Human-Induced Pluripotent Stem Cells

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Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells

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Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

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Contractile Responsiveness of Ventricular Myocytes to Isoproterenol Is Regulated by Induction of Nitric Oxide Synthase Activityin Cardiac Microvascular EndothelialCells in Heterotypic Primary Culture

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Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells

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Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment

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A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death

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Lamin A/C deficiency as a cause of familial dilated cardiomyopathy

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Gene expression, chromosome position and lamin A/C mutations

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Laminopathies and Atherosclerosis

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Vascular endothelial dysfunction in Duchenne muscular dystrophy is restored by bradykinin through upregulation of eNOS and nNOS

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New and TALENted Genome Engineering Toolbox

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ENDOTHELIAL CELL REGULATION OF CONTRACTILITY OF THE HEART

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Generation and Culture of Blood Outgrowth Endothelial Cells from Human Peripheral Blood

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Nitric Oxide and Reactive Hyperemia: Role of Location and Duration of Ischemia

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Familial dilated cardiomyopathy: Current challenges and future directions

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LMNA Mutations Associated With Mild and Late-Onset Phenotype

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Marked Vascular Dysfunction in a Case of Peripartum Cardiomyopathy

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Molecular Genetics of Dilated Cardiomyopathy

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The Role of Endothelial Dysfunction in the Development of Myocardial Fibrosis in Dilated Cardiomyopathy

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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

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Cellular and Engineered Organoids for Cardiovascular Models

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Arrhythmias as Presentation of Genetic Cardiomyopathy

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Statins improve endothelial function via suppression of epigenetic-driven EndMT

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Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production

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Abstract 442: Modeling Endothelial Dysfunction in LMNA-Related Dilated Cardiomyopathy

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Lovastatin improves endothelial cell function in LMNA-related DCM

Robson, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0432-6 · Cited by 13

Abstract 209: Downregulation of KLF2 in the Endothelium Contributes to the Pathogenesis in LMNA-related Dilated Cardiomyopathy

Sayed, N., Liu, C., Himmati, F., Zhang, J. Z., Khanamiri, S., Chen, H., Moonen, J.-R. A. J., Wnorowski, A. N., Matsa, E., Cheng, L., et al. (2018) · Circulation Research · doi:10.1161/res.123.suppl_1.209

Lovastatin for cardiolaminopathy

Czajka, C. A. (2020) · Science · doi:10.1126/science.369.6503.519-u

Abstract 3105: Lamin Mutations: Single Nuclei Multiomic Analysis Reveals Endothelial Cell Dysfunction And Its Cardiovascular Implications

Wu, D., Tripathi, D., Noishiki, C., Manhas, A., Dexheimer, R., Turbes, N., Liu, L., Cheng, P. P., Boyd, J. H., Woo, Y.-P. J., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.44.suppl_1.3105 · Cited by 1