The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy
Open accessAbstract
Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy and identify lovastatin as a therapy.
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“we used a well-established model for endothelial aging57,58 by generating human induced pluripotent stem cells (hiPSCs) from fibroblasts obtained from five independent human donors59 and subsequently differentiated them into endothelial cells (hiPSC-ECs)60.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [60]
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Cites
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Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
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KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation
SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2
Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 710
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy
Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003552 · Cited by 696
Self-citationDekker, R. J., van Soest, S., Fontijn, R. D., Salamanca, S., de Groot, P. G., VanBavel, E., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Blood · doi:10.1182/blood-2002-01-0046 · Cited by 694
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Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00082-y · Cited by 572
Self-citationCellular and Engineered Organoids for Cardiovascular Models
Thomas, D., Choi, S., Alamana, C., Parker, K. K., & Wu, J. C. (2022) · Circulation Research · doi:10.1161/circresaha.122.320305 · Cited by 100
Self-citationArrhythmias as Presentation of Genetic Cardiomyopathy
Laws, J. L., Lancaster, M. C., Shoemaker, M. B., Stevenson, W. G., Hung, R. R., Wells, Q. S., Brinkley, D. M., Hughes, S. G., Anderson, K. C., Roden, D. M., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.319835 · Cited by 92
Statins improve endothelial function via suppression of epigenetic-driven EndMT
Liu, C., Shen, M., Tan, W. L. W., Chen, I. Y., Liu, Y., Yu, X., Yang, H., Zhang, A., Liu, Y., Zhao, M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00267-1 · Cited by 88
Self-citationThomas, D., Cunningham, N. J., Shenoy, S., & Wu, J. C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab115 · Cited by 85
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Metadata
- Authors
- Sayed, N., Liu, C., Ameen, M., Himmati, F., Zhang, J. Z., Khanamiri, S., Moonen, J.-R., Wnorowski, A., Cheng, L., Rhee, J.-W., Gaddam, S., Wang, K. C., Sallam, K., Boyd, J. H., Woo, Y. J., Rabinovitch, M., & Wu, J. C.
- Affiliations
- Stanford Medicine (US)
- Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
- Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
- Corresponding author
- Sayed, Nazish
- Liu, Chun
- Wu, Joseph C.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-07-29
- Volume
- 12
- Issue
- 554
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7557117
- OpenAlex
- W3045708127
- Cited by
- 111
- References
- 64
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 23 · 2023: 24 · 2022: 14 · 2021: 16 · 2020: 3
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 HL130020, R01 HL113006, R01 HL123968, R01 HL141371, R01 HL141851, and R01 HL126527, K01 HL135455)
- American Heart Association (13SDG17340025, 19CDA34760019)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- LMNA cardiomyopathy, dilated cardiomyopathy, endothelial dysfunction, lovastatin, statins, induced pluripotent stem cell-derived endothelial cells, iPSC-derived cardiomyocytes, KLF2, angiogenesis, nitric oxide, chromatin accessibility, genome editing, reactive hyperemia
- MeSH terms
- Cardiomyopathy, Dilated, Humans, Lovastatin, Lamin Type A, Endothelial Cells, Induced Pluripotent Stem Cells
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