Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy

Flow-mediated endothelial mechanotransduction

Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802

Role of Endothelial Dysfunction in Atherosclerosis

Davignon, J., & Ganz, P. (2004) · Circulation · doi:10.1161/01.cir.0000131515.03336.f8 · Cited by 2,513

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Swift, J., Ivanovska, I. L., Buxboim, A., Harada, T., Dingal, P. C. D. P., Pinter, J., Pajerowski, J. D., Spinler, K. R., Shin, J., Tewari, M., et al. (2013) · Science · doi:10.1126/science.1240104 · Cited by 1,998

An endothelial receptor for oxidized low-density lipoprotein

Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T., et al. (1997) · Nature · doi:10.1038/386073a0 · Cited by 1,386

KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation

SenBanerjee, S., Lin, Z., Atkins, G. B., Greif, D. M., Rao, R. M., Kumar, A., Feinberg, M. W., Chen, Z., Simon, D. I., Luscinskas, F. W., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031132 · Cited by 734

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

Parmar, K. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24787 · Cited by 710

Cardiac Endothelial-Myocardial Signaling: Its Role in Cardiac Growth, Contractile Performance, and Rhythmicity

Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy

Sun, N., Yazawa, M., Liu, J., Han, L., Sanchez-Freire, V., Abilez, O. J., Navarrete, E. G., Hu, S., Wang, L., Lee, A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003552 · Cited by 696

Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2)

Dekker, R. J., van Soest, S., Fontijn, R. D., Salamanca, S., de Groot, P. G., VanBavel, E., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Blood · doi:10.1182/blood-2002-01-0046 · Cited by 694

Nesprin-1 and -2 are involved in the pathogenesis of Emery–Dreifuss muscular dystrophy and are critical for nuclear envelope integrity

Zhang, Q., Bethmann, C., Worth, N. F., Davies, J. D., Wasner, C., Feuer, A., Ragnauth, C. D., Yi, Q., Mellad, J. A., Warren, D. T., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm238 · Cited by 556

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00082-y · Cited by 572

Cellular and Engineered Organoids for Cardiovascular Models

Thomas, D., Choi, S., Alamana, C., Parker, K. K., & Wu, J. C. (2022) · Circulation Research · doi:10.1161/circresaha.122.320305 · Cited by 100

Arrhythmias as Presentation of Genetic Cardiomyopathy

Laws, J. L., Lancaster, M. C., Shoemaker, M. B., Stevenson, W. G., Hung, R. R., Wells, Q. S., Brinkley, D. M., Hughes, S. G., Anderson, K. C., Roden, D. M., et al. (2022) · Circulation Research · doi:10.1161/circresaha.122.319835 · Cited by 92

Statins improve endothelial function via suppression of epigenetic-driven EndMT

Liu, C., Shen, M., Tan, W. L. W., Chen, I. Y., Liu, Y., Yu, X., Yang, H., Zhang, A., Liu, Y., Zhao, M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00267-1 · Cited by 88

Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production

Thomas, D., Cunningham, N. J., Shenoy, S., & Wu, J. C. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab115 · Cited by 85

Endothelial cell dysfunction in cardiac disease: driver or consequence?

Allbritton‐King, J. D., & García‐Cardeña, G. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1278166 · Cited by 69

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Wang, Y., Elsherbiny, A., Kessler, L., Cordero, J., Shi, H., Serke, H., Lityagina, O., Trogisch, F. A., Mohammadi, M. M., El‐Battrawy, I., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34366-7 · Cited by 71

Advancements of 3D bioprinting in regenerative medicine: Exploring cell sources for organ fabrication

Ma, Y., Deng, B., He, R., & Huang, P. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24593 · Cited by 70

The LINC Between Mechanical Forces and Chromatin

Lityagina, O., & Dobreva, G. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.710809 · Cited by 62

Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is Protective Against Dilated Cardiomyopathy

Tang, Y., Feng, M., Su, Y., Ma, T., Zhang, H., Wu, H., Wang, X., Shi, S., Zhang, Y., Xu, Y., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064121 · Cited by 60

Targeted Therapies in Genetic Dilated and Hypertrophic Cardiomyopathies: From Molecular Mechanisms to Therapeutic Targets. A Position Paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)

de Boer, R. A., Heymans, S. R. B., Backs, J., Carrier, L., Coats, A. J. S., Dimmeler, S., Eschenhagen, T., Filippatos, G. S., Gepstein, L., Hulot, J., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2414 · Cited by 59

SGLT2 inhibitor ameliorates endothelial dysfunction associated with the commonALDH2alcohol flushing variant

Guo, H., Yu, X., Liu, Y., Paik, D. T., Justesen, J. M., Chandy, M., Jahng, J. W. S., Zhang, T., Wu, W., Rwere, F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abp9952 · Cited by 54

FDA Modernization Act 2.0 Paves the Way to Computational Biology and Clinical Trials in a Dish

Ahmed, S. M., Shivnaraine, R. V., & Wu, J. C. (2023) · Circulation · doi:10.1161/circulationaha.123.065585 · Cited by 46

Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis

Su, M., Zhao, W., Jiang, H., Zhao, Y., Liao, Z., Liu, Z., Xu, M., Jiang, S., Wu, L., Yang, Y., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00591-0 · Cited by 46

A Call to Action for New Global Approaches to Cardiovascular Disease Drug Solutions

Figtree, G. A., Broadfoot, K., Casadei, B., Califf, R. M., Crea, F., Drummond, G. R., Freedman, J. E., Guzik, T. J., Harrison, D. G., Hausenloy, D. J., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000981 · Cited by 48

A call to action for new global approaches to cardiovascular disease drug solutions

Figtree, G. A., Broadfoot, K., Casadei, B., Califf, R. M., Crea, F., Drummond, G. R., Freedman, J. E., Guzik, T. J., Harrison, D. G., Hausenloy, D. J., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab068 · Cited by 46

Clinical trials in-a-dish for cardiovascular medicine

Wu, X., Swanson, K., Yıldırım, Z., Liu, W., Liao, R., & Wu, J. C. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae519 · Cited by 42

Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish

Yıldırım, Z., Swanson, K., Wu, X., Zou, J., & Wu, J. C. (2024) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-022724-095035 · Cited by 40

Spontaneously Right‐Side‐Out‐Orientated Coupling‐Driven ROS‐Sensitive Nanoparticles on Cell Membrane Inner Leaflet for Efficient Renovation in Vascular Endothelial Injury

Qin, X., Zhu, L., Zhong, Y., Wang, Y., Wu, G.-C., Qiu, J., Wang, G., Qu, K., Zhang, K., & Wu, W. (2023) · Advanced Science · doi:10.1002/advs.202205093 · Cited by 36

Tissue‐Engineered Microvessels: A Review of Current Engineering Strategies and Applications

Zhao, N., Pessell, A. F., Zhu, N., & Searson, P. C. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303419 · Cited by 40

Clinical Trial in a Dish

Lam, C. K., & Wu, J. C. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314695 · Cited by 37

Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids

Shaji, M., Tamada, A., Fujimoto, K., Muguruma, K., Karsten, S. L., & Yokokawa, R. (2024) · Lab on a Chip · doi:10.1039/d3lc00930k · Cited by 39

Building Multi-Dimensional Induced Pluripotent Stem Cells-Based Model Platforms to Assess Cardiotoxicity in Cancer Therapies

Thomas, D., Shenoy, S., & Sayed, N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.607364 · Cited by 38

Reimagining human-centric drug development with new approach methodologies

Wu, X., Wu, M. A., Zou, J., Kleinstreuer, N., & Wu, J. C. (2026) · Science · doi:10.1126/science.aeb0045 · Cited by 37

The structure and function of lamin A/C: Special focus on cardiomyopathy and therapeutic interventions

Tiwari, V., Alam, M. J., Bhatia, M., Malladi, N., & Banerjee, S. K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122489 · Cited by 29

Alternatives to animal testing are the future — it’s time that journals, funders and scientists embrace them

Herron, T. J., Brüning‐Richardson, A., Gough, J. E., Miller, A. F., Pilkington, G. J., Greenman, J., Speirs, V., & Wu, J. C. (2025) · Nature · doi:10.1038/d41586-025-03344-6 · Cited by 27

CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID

Thomas, D., Noishiki, C., Gaddam, S., Wu, D., Manhas, A., Liu, Y., Tripathi, D., Kathale, N. D., Adkar, S. S., Garhyan, J., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00543-8 · Cited by 28

LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy

Wang, Z., Wu, J., Lv, Z., Liang, P., Li, Q., Li, Y., & Guo, Y. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.001 · Cited by 30

Power in Numbers: Harnessing Combinatorial and Integrated Screens to Advance Nanomedicine

Boehnke, N., & Hammond, P. T. (2021) · JACS Au · doi:10.1021/jacsau.1c00313 · Cited by 21

Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer

Luo, C.-K., Chou, P.-H., Ng, S.-K., Lin, W.-Y., & Wei, T.-T. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00346-0 · Cited by 23

Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling

Whitworth, C. P., & Polacheck, W. J. (2023) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2294947 · Cited by 24

Cardiac fibrosis: from mechanisms and models to medicines

Liu, W., Wu, X., Zeng, W., Chandy, M., & Wu, J. C. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.07.016 · Cited by 25

Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress

Meng, X.-M., Pang, Q., Zhou, Z., Yuan, J., You, L., Feng, Q., & Zhu, B. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107263 · Cited by 18

The effects of extracellular vesicles derived from Krüppel-Like Factor 2 overexpressing endothelial cells on the regulation of cardiac inflammation in the dilated cardiomyopathy

Zhang, W., Chen, Z., Qiao, S., Chen, S., Zheng, H., Wei, X., Li, Q., Xu, B., & Huang, W. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01284-1 · Cited by 19

Sources and applications of endothelial seed cells: a review

Deng, D., Zhang, Y., Tang, B., & Zhang, Z. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03773-6 · Cited by 19

Human Induced Pluripotent Stem Cells as a Screening Platform for Drug-Induced Vascular Toxicity

Tu, C., Cunningham, N. J., Zhang, M., & Wu, J. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.613837 · Cited by 20

Application of next generation sequencing in cardiology: current and future precision medicine implications

Papadopoulou, E., Bouzarelou, D., Tsaousis, G. S., Παπαθανασίου, Α., Vogiatzi, G., Vlachopoulos, C. V., Miliou, A., Papachristou, P., Prappa, E., Servos, G., et al. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1202381 · Cited by 18

Harnessing human genetics and stem cells for precision cardiovascular medicine

Caudal, A., Snyder, M. P., & Wu, J. C. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100445 · Cited by 21

Human Pluripotent Stem-Cell-Derived Models as a Missing Link in Drug Discovery and Development

Lin, X., Tang, J., & Lou, Y. (2021) · Pharmaceuticals · doi:10.3390/ph14060525 · Cited by 16

Tackling the challenges of new approach methods for predicting drug effects from model systems

Pang, P. D., Ahmed, S. M., Nishiga, M., Stockbridge, N., & Wu, J. C. (2024) · Nature Reviews Drug Discovery · doi:10.1038/d41573-024-00081-9 · Cited by 14

Lovastatin improves endothelial cell function in LMNA-related DCM

Robson, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0432-6 · Cited by 13

Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases

Peng, Y., Tang, Q., Xiao, F., & Fu, N. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.820857 · Cited by 12

An evidence appraisal of heart organoids in a dish and commensurability to human heart development in vivo

Thomas, D., Pérez, V. D. J., & Sayed, N. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02543-7 · Cited by 13

The age of animal experiments is waning. Where will science go next?

Kwon, D. (2026) · Nature · doi:10.1038/d41586-026-00563-3 · Cited by 11

Deconvoluting the Cells of the Human Heart with iPSC Technology: Cell Types, Protocols, and Uses

Yu, B., Zhao, S. R., Yan, C. D., Zhang, M., & Wu, J. C. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01670-z · Cited by 11

Regulation of endothelial cell differentiation in embryonic vascular development and its therapeutic potential in cardiovascular diseases

Guo, Z., & Mo, Z. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119406 · Cited by 10

Generation of Human iPSCs by Protein Reprogramming and Stimulation of TLR3 Signaling

Liu, C., Ameen, M., Himmati, S., Thomas, D., & Sayed, N. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1084-8_10 · Cited by 11

Endothelial SMAD4 Deficiency Promotes Pulmonary Hypertension by Impairing Cell Adhesion and Extracellular Matrix Organization

Lv, W., Gu, X., Zeng, L., Liu, K., Li, Y., Chen, X., Zhang, X., Zhou, X., He, J., Dai, Y., et al. (2025) · Hypertension · doi:10.1161/hypertensionaha.124.22782 · Cited by 8

The American Heart Association at 100: A Century of Scientific Progress and the Future of Cardiovascular Science: A Presidential Advisory From the American Heart Association

Elkind, M. S. V., Arnett, D. K., Benjamin, I. J., Eckel, R. H., Grant, A. O., Houser, S. R., Jacobs, A. K., Jones, D. W., Robertson, R. M., Sacco, R. L., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001213 · Cited by 11

Transcriptome studies of inherited dilated cardiomyopathies

Koslow, M., Mondaca‐Ruff, D., & Xu, X. (2023) · Mammalian Genome · doi:10.1007/s00335-023-09978-z · Cited by 7

Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective

Manhas, A., Liu, Y., Noishiki, C., Wu, D., Tripathi, D., Mirza, S., Thomas, D., Liu, L., Guha, A., Nguyen, P. K. P., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adv9403 · Cited by 8

Simvastatin rescues vascular health by targeting epigenetic-regulated endothelial-to-mesenchymal transition: a revival of pleiotropic effects?

Liuzzo, G., & Pedicino, D. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad397 · Cited by 6

Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function

Elezaby, A., Dexheimer, R., Wu, D., Chan, S. Y., Tacco, I. R., Chen, I. Y., Sayed, N., & Sallam, K. (2025) · Journal of Vascular Research · doi:10.1159/000548353 · Cited by 6

Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

Chaudhary, N., & Villa-Diaz, L. G. (2025) · Frontiers in Toxicology · doi:10.3389/ftox.2025.1667573 · Cited by 7

The role of the angiography-derived index of microcirculatory resistance in the prognosis of patients with dilated cardiomyopathy

Li, M., Su, H., Zuo, Z., Zhang, Z., Li, M., Su, F., Yao, W., He, Y., Kong, X., & Wang, H. (2023) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-22-1060 · Cited by 6

Generation of two iPSC lines from vascular Ehlers-Danlos Syndrome (vEDS) patients carrying a missense mutation in COL3A1 gene

Manhas, A., Tripathi, D., Noishiki, C., Wu, D., Liu, L., Sallam, K., Lee, J. T., Fukaya, E., & Sayed, N. (2024) · Stem Cell Research · doi:10.1016/j.scr.2024.103485 · Cited by 6

Advancing Cardiac Organoid Engineering Through Application of Biophysical Forces

Blazeski, A., García‐Cardeña, G., & Kamm, R. D. (2024) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2024.3514378 · Cited by 7

Nuclear envelope components in vascular mechanotransduction: emerging roles in vascular health and disease

Nguyen, T., Winek, M. A., Rao, M. K., Dhyani, S. P., & Lee, M. Y. (2025) · Nucleus · doi:10.1080/19491034.2025.2453752 · Cited by 6

Biosensor-based profiling to track cellular signalling in patient-derived models of dilated cardiomyopathy

Bourque, K., Hawey, C., Jiang, A., Mazarura, G. R., & Hébert, T. E. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110239 · Cited by 6

Generation of two induced pluripotent stem cell lines from spinal muscular atrophy type 1 patients carrying no functional copies of SMN1 gene

Zeng, W., Kong, X., Alamana, C., Liu, Y., Guzman, J., Pang, P. D., Day, J., & Wu, J. C. (2023) · Stem Cell Research · doi:10.1016/j.scr.2023.103095 · Cited by 6

Stem cells in the treatment of myocardial injury-induced cardiomyopathy: mechanisms and efficient utilization strategies

Yang, J., Yue, T., He, J. X., Xiong, S., Luo, Y., & Hou, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1600604 · Cited by 5

Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies

Thomas, D., Yang, P. C.-M., Wu, J. C., & Sayed, N. (2025) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2025.09.008 · Cited by 6

Harnessing iPSCs, 3D organoids, and multiomics to model rare vascular diseases: Emerging new approach methodologies

Liu, L., Wu, D., Tsao, P. S., Leeper, N. J., & Sayed, N. (2026) · Vascular Medicine · doi:10.1177/1358863x251394285 · Cited by 5

From bedside to the bench: patient-specific hiPSC-EC models uncover endothelial dysfunction in genetic cardiomyopathies

Rabino, M., Sommariva, E., Zacchigna, S., & Pompilio, G. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1237101 · Cited by 5

A Novel Stem Cell Model to Study Preeclampsia Endothelial Dysfunction

Wu, Y., Sun, T., Medina, P., Narasimhan, P., Stevenson, D. K., von Versen‐Höynck, F., Armstrong, J., Wu, J. C., Sayed, N., & Winn, V. D. (2024) · Reproductive Sciences · doi:10.1007/s43032-024-01590-z · Cited by 7

Generation of induced pluripotent stem cell line from a patient suffering from arterial calcification due to deficiency of CD73 (ACDC)

Tripathi, D., Manhas, A., Noishiki, C., Wu, D., Adkar, S. S., Sallam, K., Fukaya, E., Leeper, N. J., & Sayed, N. (2023) · Stem Cell Research · doi:10.1016/j.scr.2023.103285 · Cited by 5

Non-Cell-Autonomous Cardiomyocyte Regulation Complicates Gene Supplementation Therapy for Lmna-Associated Cardiac Defects in Mice

Sun, Y., Guo, C., Chen, Z., Lin, J., Yang, L., Zhang, Y., Wu, C., Zhao, D., Jardin, B. D., Pu, W. T., et al. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.06.004 · Cited by 6

The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modeling

Juguilon, C., & Wu, J. C. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050947 · Cited by 6

Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer

Manhas, A., Tripathi, D., Thomas, D., & Sayed, N. (2024) · Current Cardiology Reports · doi:10.1007/s11886-024-02099-2 · Cited by 5

Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications

Liu, Y., Zhang, Z., Li, H., Prados‐Martin, L., Li, H., Cheng, F., Tu, X., Lim, K. S., Li, W., & Wang, M. (2026) · Advanced Science · doi:10.1002/advs.74917 · Cited by 5

An alpha-helix variant p.Arg156Pro in LMNA as a cause of hereditary dilated cardiomyopathy: genetics and bioinfomatics exploration

Chang, L., Huang, R., Chen, J., Li, G., Shi, G., Xu, B., & Wang, L. Y. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01661-1 · Cited by 4

Cracking the code of the cardiovascular enigma: hPSC-derived endothelial cells unveil the secrets of endothelial dysfunction

Kiskin, F. N., Yang, Y., Yang, H., & Zhang, J. Z. (2024) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2024.05.005 · Cited by 3

Stem cells research prospects towards precision medicine

Surbhi, J. A. I. N., SINGH, A. P., KUMAR, A., Saluja, R., & Nema, R. (2022) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2022_128 · Cited by 3

Induced Pluripotent Stem Cells: Advances and Applications in Regenerative Medicine

Kizub, I. V., Rozhok, A. I., & Bilousova, G. (2023) · Biochemistry · doi:10.5772/intechopen.109274 · Cited by 3

Statin therapy improves endothelial dysfunction

Crunkhorn, S. (2020) · Nature Reviews Drug Discovery · doi:10.1038/d41573-020-00137-6 · Cited by 3

A protocol for transdifferentiation of human cardiac fibroblasts into endothelial cells via activation of innate immunity

Liu, C., Medina, P., Thomas, D., Chen, I. Y., Sallam, K., Sayed, D. H., & Sayed, N. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100556 · Cited by 3

Human iPSC models of cardiac electrophysiology and arrhythmia

Yang, B., Lowenthal, J., Tomaselli, G. F., & Tung, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85767-3.00006-2 · Cited by 3

Drug Discovery in Induced Pluripotent Stem Cell Models

Bourque, K., Mnasri, N., Jones-Tabah, J., Martins-Cannavino, K., & Hébert, T. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00049-9 · Cited by 1

Polycyclic-Fused Cytochalasins with Anti-Liver Fibrosis Activity Produced by the Endophytic Fungus Trichoderma harzianum

Zhang, Y.-J., Liao, Y.-L., Gan, L., Jiang, L., Yuan, T., Yin, S., & Tang, G. (2026) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6c00375 · Cited by 2

RUNX1-driven endothelial-to-mesenchymal transition contributes to remodelling in LMNA cardiomyopathy

Wu, D., Tripathi, D., Manhas, A., Noishiki, C., Liu, L., Wu, C. A., Venkateshappa, R., Zhang, H., Ren, L., Thomas, D., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag619 · Cited by 2

Nuclear envelope myopathy

Hayashi, Y. K. (2022) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12602 · Cited by 2

Emerging Targeted Therapies for Inherited Cardiomyopathies and Arrhythmias

Ryan, T. L., & Roberts, J. D. (2023) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2023.04.006 · Cited by 3

Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction

Monte-Monge, A. D., de Lara, Í. R.-P., Gonzalo, P., Espinós‐Estévez, C., González‐Amor, M., de la Fuente‐Pérez, M., Andrés‐Manzano, M. J., Fanjul, V., Gimeno, J. R., Villa, R. B., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311172 · Cited by 2

Understanding genomic medicine for thoracic aortic disease through the lens of induced pluripotent stem cells

Singh, A. A., Shetty, D. K., Jacob, A. G., Bayraktar, S., & Sinha, S. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1349548 · Cited by 3

Chronic Administration of Red Yeast Rice Mitigates Endothelial Dysfunction in Spontaneously Hypertensive Rats by Inhibiting Oxidative Stress and Endothelial Nitric Oxide Synthase Uncoupling

Tan, J. J., Murugan, D. D., Ling, W. C., Lee, S.-K., & Wh, K. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611295900240529104225 · Cited by 2

Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells

Tang, P., Wei, F., Qiao, W., Chen, X., Ji, C., Yang, W., Zhang, X., Chen, S., Wu, Y., Jiang, M.-X., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.11.018 · Cited by 2

Generation of induced pluripotent stem cell line from a patient with long COVID

Wu, D., Manhas, A., Noishiki, C., Tripathi, D., Liu, L., Turbes, N., Thomas, D., Sallam, K., Lee, J. T., & Sayed, N. (2025) · Stem Cell Research · doi:10.1016/j.scr.2025.103652 · Cited by 2

Lamin: guardian against DNA damage by transcription stress

Jahng, J. W. S., & Wu, J. C. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae122 · Cited by 2

Modeling the contribution of cardiac fibroblasts in dilated cardiomyopathy using induced pluripotent stem cells

Mazarura, G. R., & Hébert, T. E. (2024) · Molecular Pharmacology · doi:10.1124/molpharm.124.000958 · Cited by 1

Telomere shortening in laminopathic dilated cardiomyopathy

Chang, A. C. Y., Pardon, G., Chang, A. C.-H., Wang, C., Termglinchan, V., Кіріллова, А., Nicin, L., Birnbaum, F., Laquerrière, A., Bonne, G., et al. (2026) · npj Regenerative Medicine · doi:10.1038/s41536-026-00462-1 · Cited by 1

Targeting an atypical G protein–coupled receptor signaling pathway for cardiac fibrosis therapy

Zhang, H., Shivnaraine, R. V., Ren, L., Thai, P. N., Janicot, R., Zhu, W., Huang, R., Siepe, D. H., Tu, C., Liu, W., et al. (2026) · Science · doi:10.1126/science.aej5896 · Cited by 1

Heterozygous LMNA mutation-carrying iPSC lines from three cardiac laminopathy patients

Cho, S., Lee, C., Lai, C., Zhuge, Y., Haddad, F., Fowler, M. B., Sallam, K., & Wu, J. C. (2022) · Stem Cell Research · doi:10.1016/j.scr.2022.102657 · Cited by 1

ALDH2 mutation results in excessive basal nitric oxide production and a delayed response to nitroglycerin

Zhu, H., Hu, J., Dong, Z., Liu, Y., Sun, X., & Sun, A. (2022) · Cardiology Plus · doi:10.1097/cp9.0000000000000011 · Cited by 1

Generation of induced pluripotent stem cell lines from South Asian ethnicity

Khokhar, Y., Bhowmik, A. T., Zhao, S. R., Cook, Z., Nallamshetty, S., & Wu, J. C. (2023) · Stem Cell Research · doi:10.1016/j.scr.2023.103272 · Cited by 1

Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathyPreprint

Sun, Y., Guo, C., Chen, Z., Lin, J., Yang, L., Zhang, Y., Wu, C., Zhao, D., Jardin, B. D., Pu, W. T., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.18.549413 · Cited by 1

Introducing AHA's New President: Joseph C. Wu, MD, PhD, FAHA

Kuehn, B. M. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.031618 · Cited by 2

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainPreprint

Chakraborty, M., Shi, S. M., Porter, I. E., Richard, D. J., Marinov, G. K., Murthy, M. N., Moore, A. A., Blum, J. L. E., Natarajan, A., Jahng, J. W. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680371 · Cited by 2

The Effects of Extracellular Vesicles Derived From Krüppel-like Factor 2 Overexpressed Endothelial Cells on the Regulation of Cardiac Inflammation in the Dilated CardiomyopathyPreprint

Zhang, W., Chen, Z., Qiao, S., Chen, S., Zheng, H., Wei, X., Li, Q., Xu, B., & Huang, W. (2021) · Research Square · doi:10.21203/rs.3.rs-618179/v1

Induced pluripotent stem cells for cardiovascular therapeutics: Progress and perspectives

Kizub, I. V. (2023) · Regulatory Mechanisms in Biosystems · doi:10.15421/10.15421/022366

Emery-Dreifuss Muscular Dystrophies

Hayashi, Y. K. (2023) · Current clinical neurology · doi:10.1007/978-3-031-44009-0_10

Abstract 442: Modeling Endothelial Dysfunction in LMNA-Related Dilated Cardiomyopathy

Sayed, N., Liu, C., Himmati, F., Zhang, J. Z., Termglinchan, V., Moonen, J.-R. A. J., Stack, J., Chen, H., Matsa, E., Sallam, K., et al. (2017) · Circulation Research · doi:10.1161/res.121.suppl_1.442

Lovastatin improves endothelial cell function in LMNA-related DCM

Robson, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0432-6 · Cited by 13

Abstract 209: Downregulation of KLF2 in the Endothelium Contributes to the Pathogenesis in LMNA-related Dilated Cardiomyopathy

Sayed, N., Liu, C., Himmati, F., Zhang, J. Z., Khanamiri, S., Chen, H., Moonen, J.-R. A. J., Wnorowski, A. N., Matsa, E., Cheng, L., et al. (2018) · Circulation Research · doi:10.1161/res.123.suppl_1.209

Lovastatin for cardiolaminopathy

Czajka, C. A. (2020) · Science · doi:10.1126/science.369.6503.519-u

Abstract 3105: Lamin Mutations: Single Nuclei Multiomic Analysis Reveals Endothelial Cell Dysfunction And Its Cardiovascular Implications

Wu, D., Tripathi, D., Noishiki, C., Manhas, A., Dexheimer, R., Turbes, N., Liu, L., Cheng, P. P., Boyd, J. H., Woo, Y.-P. J., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.44.suppl_1.3105 · Cited by 1