Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment

Riba, Ambre; Hassani, Kasra; Walker, Alesia; van Best, Niels; von Zeschwitz, Dunja; Anslinger, Teresa; Sillner, Nina; Rosenhain, Stefanie; Eibach, Daniel; Maiga-Ascofaré, Oumou; Rolle-Kampczyk, Ulrike; Basic, Marijana; Binz, Anne; Mocek, Sabine; Sodeik, Beate; Bauerfeind, Rudolf; Mohs, Antje; Trautwein, Christian; Kiessling, Fabian; May, Jürgen; Klingenspor, Martin; Gremse, Felix; Schmitt-Kopplin, Philippe; Bleich, André; Torow, Natalia; von Bergen, Martin; Hornef, Mathias W.

doi:10.1126/scitranslmed.aay7019

Cited by 45

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Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment

Riba, Ambre, Hassani, Kasra, Walker, Alesia, van Best, Niels, von Zeschwitz, Dunja, Anslinger, Teresa, Sillner, Nina, Rosenhain, Stefanie, Eibach, Daniel, Maiga-Ascofaré, Oumou, Rolle-Kampczyk, Ulrike, Basic, Marijana, Binz, Anne, Mocek, Sabine, Sodeik, Beate, Bauerfeind, Rudolf, Mohs, Antje, Trautwein, Christian, Kiessling, Fabian, May, Jürgen, Klingenspor, Martin, Gremse, Felix, Schmitt-Kopplin, Philippe, Bleich, André, Torow, Natalia, von Bergen, Martin, Hornef, Mathias W.·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.aay7019

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Abstract

The protozoan parasite Giardia lamblia enhances bile secretion and microbiota–mediated bile acid deconjugation in mice, leading to growth impairment.

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Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics
Packi, K., Świerczewski, D., Klimczak, S., Ochab, D., Gałęziewska, J., Gromek, P., Kruczkowska, W., Płuciennik, E., Kałuzińska-Kołat, Ż., & Kołat, D. (2026) · Antonie van Leeuwenhoek · doi:10.1007/s10482-026-02425-4

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Authors: Riba, A., Hassani, K., Walker, A., van Best, N., von Zeschwitz, D., Anslinger, T., Sillner, N., Rosenhain, S., Eibach, D., Maiga-Ascofaré, O., Rolle-Kampczyk, U., Basic, M., Binz, A., Mocek, S., Sodeik, B., Bauerfeind, R., Mohs, A., Trautwein, C., Kiessling, F., May, J., Klingenspor, M., Gremse, F., Schmitt-Kopplin, P., Bleich, A., Torow, N., von Bergen, M., & Hornef, M. W.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-10-14
Volume: 12
Issue: 565
ISSN: 1946-6234
1946-6242
DOI: 10.1126/scitranslmed.aay7019
Cited by: 45
References: 7
Language: en
Funders: Deutsche Forschungsgemeinschaft (SPP1656 HO2236/9-2, HO2236/14-1, HO2236/17-1, CRC1382 project A5, CRC1382 project A8, CRC1382 project B1, CRC1382 project Q1, SPP1656 BL953/5-2, BL953/5-2, CRC900 project C2 - Projektnummer 158989968 – SFB 900, CRC1371 project P13, TO1052/1-1)
Interdisciplinary Center for Clinical Research, Faculty of Medicine, RWTH Aachen University (Grant E8-13)
German Centrefor Infection Research (8000 201-3)
German Center for Infection Research (8000 201-3)
German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems, Germany (8000 201-3)

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This page: CoChat. (2026). Citation check: Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment. https://app.cochat.ai/papers/10.1126/scitranslmed.aay7019
The paper: Riba, A., Hassani, K., Walker, A., van Best, N., von Zeschwitz, D., Anslinger, T., Sillner, N., Rosenhain, S., Eibach, D., Maiga-Ascofaré, O., Rolle-Kampczyk, U., Basic, M., Binz, A., Mocek, S., Sodeik, B., Bauerfeind, R., Mohs, A., Trautwein, C., Kiessling, F., . . . Hornef, M. W. (2020). Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aay7019

Disturbed gut microbiota and bile homeostasis in Giardia -infected mice contributes to metabolic dysregulation and growth impairment

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