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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Open accessAbstract
Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice.
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Cites
Role of YAP/TAZ in mechanotransduction
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Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
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A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP
Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418
YAP1 increases organ size and expands undifferentiated progenitor cells
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The emerging roles of YAP and TAZ in cancer
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Yap1 acts downstream of α-catenin to control epidermal proliferation
Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036
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Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Mascharak, S., desJardins-Park, H. E., Davitt, M. F., Griffin, M., Borrelli, M. R., Moore, A. L., Chen, K., Duoto, B. A., Chinta, M. S., Foster, D. S., et al. (2021) · Science · doi:10.1126/science.aba2374 · Cited by 630
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity
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Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression
Cai, X., Wang, K.-C., & Meng, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673599 · Cited by 333
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Metadata
- Authors
- Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., Marlow, M. M., Turner, S. M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D. D. S., Ma, H.-Y., Duwaerts, C. C., Espanol-Suner, R., Wei, L., Newcomb, B., Mileva, I., Canals, D., Hannun, Y. A., Chung, R. T., Mattis, A. N., Fuchs, B. C., Tager, A. M., Yimlamai, D., Weaver, V. M., Mullen, A. C., Sheppard, D., & Chen, J. Y.
- Affiliations
- University of California, San Francisco (US)
- Yale University (US)
- University of California, Los Angeles (US)
- Pliant (United States) (US)
- Kaiser Permanente (US)
- Harvard University (US)
- Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
- Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
- Stony Brook University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Tager, Andrew M.
- Sheppard, Dean
- Chen, Jennifer Y.
- ORCID
- Alsamman, Sarah
- Christenson, Stephanie A.
- Yu, Amy
- Ayad, Nadia M. E.
- Mooring, Meghan S.
- Segal, Joe M.
- Hu, Jimmy Kuang-Hsien
- Rao, Vikram
- Turner, Scott M.
- Sedki, Mai
- Pantano, Lorena
- Ferreira, Diego Dos Santos
- Ma, Hsiao-Yen
- Duwaerts, Caroline C.
- Wei, Lan
- Newcomb, Benjamin
- Canals, Daniel
- Hannun, Yusuf A.
- Chung, Raymond T.
- Mattis, Aras N.
- Fuchs, Bryan C.
- Tager, Andrew M.
- Yimlamai, Dean
- Weaver, Valerie M.
- Mullen, Alan C.
- Sheppard, Dean
- Chen, Jennifer Y.
- Venue
- Science Translational Medicine
- Published
- 2020-08-19
- Volume
- 12
- Issue
- 557
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7976849
- OpenAlex
- W3073968329
- Cited by
- 122
- References
- 89
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 19 · 2023: 21 · 2022: 24 · 2021: 20 · 2020: 2
- FWCI
- 9.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK114548, P30DK026743)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- acid ceramidase, liver fibrosis, hepatic stellate cells, YAP/TAZ signaling, ceramide, tricyclic antidepressants, β-TrCP, proteasomal degradation, antifibrotic therapy, therapeutic target
- MeSH terms
- Animals, Fibrosis, Humans, Signal Transduction, Adaptor Proteins, Signal Transducing, Mice, Hepatic Stellate Cells, Acid Ceramidase
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