Cited by 122Liver physiology and pathologySphingolipid Metabolism and SignalingHippo pathway signaling and YAP/TAZ

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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

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Alsamman, Sarah, Christenson, Stephanie A., Yu, Amy, Ayad, Nadia M. E., Mooring, Meghan S., Segal, Joe M., Hu, Jimmy Kuang-Hsien, Schaub, Johanna R., Ho, Steve S., Rao, Vikram, Marlow, Megan M., Turner, Scott M., Sedki, Mai, Pantano, Lorena, Ghoshal, Sarani, Ferreira, Diego Dos Santos, Ma, Hsiao-Yen, Duwaerts, Caroline C., Espanol-Suner, Regina, Wei, Lan, Newcomb, Benjamin, Mileva, Izolda, Canals, Daniel, Hannun, Yusuf A., Chung, Raymond T., Mattis, Aras N., Fuchs, Bryan C., Tager, Andrew M., Yimlamai, Dean, Weaver, Valerie M., Mullen, Alan C., Sheppard, Dean, Chen, Jennifer Y.·2020·Science Translational Medicine

DOI 10.1126/scitranslmed.aay8798PMC PMC7976849

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Abstract

Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice.

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Authors: Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., Marlow, M. M., Turner, S. M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D. D. S., Ma, H.-Y., Duwaerts, C. C., Espanol-Suner, R., Wei, L., Newcomb, B., Mileva, I., Canals, D., Hannun, Y. A., Chung, R. T., Mattis, A. N., Fuchs, B. C., Tager, A. M., Yimlamai, D., Weaver, V. M., Mullen, A. C., Sheppard, D., & Chen, J. Y.
Affiliations: University of California, San Francisco (US)
Yale University (US)
University of California, Los Angeles (US)
Pliant (United States) (US)
Kaiser Permanente (US)
Harvard University (US)
Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
Stony Brook University (US)
Massachusetts General Hospital (US)
Corresponding author: Tager, Andrew M.
Sheppard, Dean
Chen, Jennifer Y.
ORCID: Alsamman, Sarah
Christenson, Stephanie A.
Yu, Amy
Ayad, Nadia M. E.
Mooring, Meghan S.
Segal, Joe M.
Hu, Jimmy Kuang-Hsien
Rao, Vikram
Turner, Scott M.
Sedki, Mai
Pantano, Lorena
Ferreira, Diego Dos Santos
Ma, Hsiao-Yen
Duwaerts, Caroline C.
Wei, Lan
Newcomb, Benjamin
Canals, Daniel
Hannun, Yusuf A.
Chung, Raymond T.
Mattis, Aras N.
Fuchs, Bryan C.
Tager, Andrew M.
Yimlamai, Dean
Weaver, Valerie M.
Mullen, Alan C.
Sheppard, Dean
Chen, Jennifer Y.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2020-08-19
Volume: 12
Issue: 557
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aay8798
PMC: PMC7976849
OpenAlex: W3073968329
Cited by: 122
References: 89
Citations by year: 2026: 13 · 2025: 23 · 2024: 19 · 2023: 21 · 2022: 24 · 2021: 20 · 2020: 2
FWCI: 9.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (K08DK114548, P30DK026743)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: acid ceramidase, liver fibrosis, hepatic stellate cells, YAP/TAZ signaling, ceramide, tricyclic antidepressants, β-TrCP, proteasomal degradation, antifibrotic therapy, therapeutic target
MeSH terms: Animals, Fibrosis, Humans, Signal Transduction, Adaptor Proteins, Signal Transducing, Mice, Hepatic Stellate Cells, Acid Ceramidase

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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

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