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A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease
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The second X chromosome confers resilience in a mouse model of Alzheimer’s disease potentially through the X-linked gene Kdm6a .
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“Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD)”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [9]
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“it has also been reported men with AD have an increased risk for death [9–11]”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [9]
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Additional file 6 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367119
Additional file 2 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367107
Additional file 1 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367104
Additional file 7 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367122
Additional file 3 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367110
Additional file 5 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367116
Additional file 4 of Sex-biased and parental allele-specific gene regulation by KDM6A
Ma, W., Fang, H., Pease, N., Filippova, G. N., Distèche, C. M., & Berletch, J. B. (2022) · Figshare · doi:10.6084/m9.figshare.20367113
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Metadata
- Authors
- Davis, E. J., Broestl, L., Abdulai-Saiku, S., Worden, K., Bonham, L. W., Miñones-Moyano, E., Moreno, A. J., Wang, D., Chang, K., Williams, G., Garay, B. I., Lobach, I., Devidze, N., Kim, D., Anderson-Bergman, C., Yu, G.-Q., White, C. C., Harris, J. A., Miller, B. L., Bennett, D. A., Arnold, A. P., De Jager, P. L., Palop, J. J., Panning, B., Yokoyama, J. S., Mucke, L., & Dubal, D. B.
- Affiliations
- University of California, San Francisco (US)
- Gladstone Institutes (US)
- Broad Institute (US)
- Allen Institute for Brain Science (US)
- Rush University Medical Center (US)
- University of California, Los Angeles (US)
- Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.
- Corresponding author
- Davis, Emily J.
- Broestl, Lauren
- Dubal, Dena B.
- ORCID
- Davis, Emily J.
- Broestl, Lauren
- Abdulai-Saiku, Samira
- Worden, Kurtresha
- Bonham, Luke W.
- Miñones-Moyano, Elena
- Moreno, Arturo J.
- Wang, Dan
- Chang, Kevin
- Williams, Gina
- Garay, Bayardo I.
- Lobach, Iryna
- Kim, Daniel
- Anderson-Bergman, Cliff
- White, Charles C.
- Harris, Julie A.
- Miller, Bruce L.
- Bennett, David A.
- Arnold, Arthur P.
- De Jager, Phil L.
- Palop, Jorge J.
- Panning, Barbara
- Yokoyama, Jennifer S.
- Mucke, Lennart
- Dubal, Dena B.
- Venue
- Science Translational Medicine
- Published
- 2020-08-26
- Volume
- 12
- Issue
- 558
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8409261
- OpenAlex
- W3080470877
- Cited by
- 176
- References
- 141
- Citations by year
- 2026: 19 · 2025: 32 · 2024: 28 · 2023: 26 · 2022: 44 · 2021: 21 · 2020: 6
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (1650113)
- National Institutes of Health (AG023501, NS043196, AG011385 and NS065780, P30AG10161, R01AG15819, and R01AG17917, U01AG46152 and U01AG61356, CTSI UL1 TR000004, AG049152, NS092918 and AG034531, R01AG36836)
- Larry L. Hillblom Foundation
- American Federation for Aging Research
- Glenn Foundation for Medical Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, X chromosome, sex chromosomes, resilience, cognitive decline, aging, preclinical Alzheimer's disease, mouse model, brain gene expression, disease susceptibility
- MeSH terms
- Alzheimer Disease, Animals, Female, Male, Sex Characteristics, Testis, X Chromosome, Y Chromosome, Mice
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